Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers von Jahn, A., Rump, A., Widmann, T.J., Heining, C., Horak, P., Hutter, B., Paramasivam, N., Uhrig, S., Gieldon, L., Drukewitz, S., Kübler, A., Bermudez, M., Hackmann, K., Porrmann, J., Wagner, J., Arlt, M., Franke, M., Fischer, J., Kowalzyk, Z., William, D., Weth, V., Oster, S., Fröhlich, M., Hüllein, J., Valle González, C., Kreutzfeldt, S., Mock, A., Heilig, C.E., Lipka, D.B., Möhrmann, L., Hanf, D., Oleś, M., Teleanu, V., Allgäuer, M., Ruhnke, L., Kutz, O., Knurr, A., Laßmann, A., Endris, V., Neumann, O., Penzel, R., Beck, K., Richter, D., Winter, U., Wolf, S., Pfütze, K., Geörg, C., Meißburger, B., Buchhalter, I., Augustin, M., Aulitzky, W.E., Hohenberger, P., Kroiss, M., Schirmacher, P., Schlenk, R.F., Keilholz, U., Klauschen, F., Folprecht, G., Bauer, S., Siveke, J.T., Brandts, C.H., Kindler, T., Boerries, M., Illert, A.L., von Bubnoff, N., Jost, P.J., Metzeler, K.H., Bitzer, M., Schulze-Osthoff, K., von Kalle, C., Brors, B., Stenzinger, A., Weichert, W., Hübschmann, D., Fröhling, S., Glimm, H., Schröck, E., Klink, B.

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Cutaneous epithelioid haemangiomas show somatic mutations in the mitogen‐activated protein kinase pathway von Maurus, K., Kosnopfel, C., Kneitz, H., Appenzeller, S., Schrama, D., Glutsch, V., Roth, S., Gerhard‐Hartmann, E., Rosenfeldt, M., Möhrmann, L., Fröhlich, M., Hübschmann, D., Stenzinger, A., Glimm, H., Fröhling, S., Goebeler, M., Rosenwald, A., Kutzner, H., Schilling, B.

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Pan-cancer analysis of genomic scar patterns caused by homologous repair deficiency (HRD) von Rempel, E., Kluck, K., Beck, S., Ourailidis, I., Kazdal, D., Neumann, O., Volckmar, A. L., Kirchner, M., Goldschmid, H., Pfarr, N., Weichert, W., Hübschmann, D., Fröhling, S., Sutter, C., Schaaf, C. P., Schirmacher, P., Endris, V., Stenzinger, A., Budczies, J.

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Combined single‐cell and spatially‐resolved mapping of lymph node ecosystems reveals principles of lymphoma tissue organization von Czernilofsky, F., Mathioudaki, A., Jopp‐Saile, L., Lutz, R., Vonficht, D., Baertsch, M., Vohringer, H., Roider, T., Ordoñez‐Rueda, D., Pabst, C., Huber, W., Trumpp, A., Müller‐Tidow, C. Carsten, Zaugg, J., Hübschmann, D., Haas, S., Dietrich, S.

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CYTIDINE DEAMINASES SHAPE THE GENOME OF GERMINAL CENTER B CELL DERIVED LYMPHOMA von Ren, M., Sidiropoulou, E., Tasakis, R. N., Donato, E., Gonzalez‐Menendez, I., Busse, C. E, Luck, T. J, Dolnik, A., Bullinger, L., Trumpp, A., Quintanilla‐Martinez, L., Kreuz, M., Chapuy, B., Hübschmann, D., Siebert, R., Papavasiliou, F N., Sander, S.

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COGNITION: a prospective precision oncology trial for patients with early breast cancer at high risk following neoadjuvant chemotherapy von Pixberg, C., Zapatka, M., Hlevnjak, M., Benedetto, S., Suppelna, J.P., Heil, J., Smetanay, K., Michel, L., Fremd, C., Körber, V., Rübsam, M., Buschhorn, L., Heublein, S., Schäfgen, B., Golatta, M., Gomez, C., von Au, A., Wallwiener, M., Wolf, S., Dikow, N., Schaaf, C., Gutjahr, E., Allgäuer, M., Stenzinger, A., Pfütze, K., Kirsten, R., Hübschmann, D., Sinn, H.-P., Jäger, D., Trumpp, A., Schlenk, R., Höfer, T., Thewes, V., Schneeweiss, A., Lichter, P.

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Rationale and design of the CRAFT (Continuous ReAssessment with Flexible ExTension in Rare Malignancies) multicenter phase II trial von Heilig, C.E., Horak, P., Kreutzfeldt, S., Teleanu, V., Mock, A., Renner, M., Bhatti, I.A., Hutter, B., Hüllein, J., Fröhlich, M., Uhrig, S., Süße, H., Heiligenthal, L., Ochsenreither, S., Illert, A.L., Vogel, A., Desuki, A., Heinemann, V., Heidegger, S., Bitzer, M., Scheytt, M., Brors, B., Hübschmann, D., Baretton, G., Stenzinger, A., Steindorf, K., Benner, A., Jäger, D., Heining, C., Glimm, H., Fröhling, S., Schlenk, R.F.

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210P Therapeutic implications of phosphoproteomics in molecular cancer diagnostics von Schneider, A., Woortman, J., Jensen, C.B., Sakhteman, A., Hamood, F., Teleanu, M-V., Horak, P., Kreutzfeldt, S., Resch, M., Stange, C., Pfister, S.M., Witt, O., Jones, D., The, M., Hübschmann, D., Fröhling, S., Kuster, B.

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56P Multi-omic profiling in cholangiocarcinoma to enable scientific advancement within the DKFZ/NCT/DKTK MASTER study von Nichetti, F., Korell, F., Schwab, M., Hoffmeister, P.K.M., Hüllein, J., Uhrig, S., Teleanu, M-V., Kreutzfeldt, S., Horak, P., Glimm, H., Heining, C., Rieke, D.T., Kindler, T., Hübschmann, D., Springfeld, C., Jenzer, M., Heilig, C.E., Fröhling, S., Köhler, B.C.

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1936P Targeted therapy of desmoplastic small round cell tumor guided by multilayered molecular profiling von Renner, M., Oleś, M., Paramasivam, N., Schneider, A., Heilig, C.E., Modugno, C., Herremans, C., Mock, A., Lipka, D., Bauer, S., Kindler, T., Brandts, C.H., Keilholz, U., Boerries, M., Kuster, B., Hübschmann, D., Schlesner, M., Glimm, H., Schlenk, R.F., Fröhling, S.

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131O A composite biomarker for evaluation of homologous recombination repair deficiency in a pan-cancer cohort von Rübsam, M., Rheinnecker, M., Hutter, B., Fröhlich, M., Heilig, C.E., Paramasivam, N., Oleś, M., Ball, C., Glimm, H., Hlevnjak, M., Zapatka, M., Lichter, P., Fröhling, S., Schlenk, R.F., Hübschmann, D.

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2318P Value of broad molecular profiling for cancer diagnosis von Werstein, L.V.A., Heilig, C.E., Teleanu, M-V., Hüllein, J., Singh, M., Bauer, S., Kindler, T., Klauschen, F., Brandts, C.H., Rieke, D.T., Illert, L., Börries, M., Kreutzfeldt, S., Horak, P., Hübschmann, D., Lipka, D.B., Glimm, H., Hartmann, W., Fröhling, S.

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1772P Phosphoproteomic biomarker for afatinib response stratification in advanced chordoma von Stange, C., Schneider, A., Jensen, C.B., Sakhteman, A., Teleanu, M-V., Horak, P., Kreutzfeldt, S., Oles, M., Heilig, C.E., Punturi, N., Dolat, L., Resch, M., Hamood, F., Herold-Mende, C., Hübschmann, D., Wilhelm, S., Freed, D.M., The, M., Fröhling, S., Kuster, B.

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1784TiP Pasireotide as maintenance treatment in SSTR2/3/5-expressing synovial sarcoma and desmoplastic small round cell tumor: The PAMSARC study von Schlenk, R.F., Heining, C., Gnutzmann, E., Roldan, S.S.L., Heiligenthal, L., Sparber Sauer, M., Hahn, D.A., Dirksen, U., Hamacher, R.W., Floercken, A., Thorwarth, A., Deinzer, C., Gaidzik, V., van Tilburg, C.M., Hübschmann, D., Arndt, K., Pfister, S.M., Glimm, H., Fröhling, S., Heilig, C.E.

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198P Inavolisib in cancers with activating PIK3CA mutations: Results from the CRAFT trial von Heilig, C.E., Teleanu, M-V., Desuki, A., Kindler, T., Deschler, B., Kunzmann, V., von Bubnoff, N., Illert, L., Rieke, D.T., Süsse, H., Heiligenthal, L., Kreutzfeldt, S., Horak, P., Steindorf, K., Benner, A., Hübschmann, D., Schweigert, N., Glimm, H., Fröhling, S., Schlenk, R.F.

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196P Randomized phase II study of trabectedin/olaparib compared to physician’s choice in subjects with previously treated advanced or recurrent solid tumors harboring DNA repair de... von Schlenk, R.F., Rübsam, M., Teleanu, M-V., Richter, S., Siveke, J.T., Wagner, S., Kopp, H-G., Kindler, T., Illert, L., Golf, A.H-E., Dorman, K., Schreck, N., Benner, A., Süsse, H., Freitag, A., von Kalle, C., Glimm, H., Hübschmann, D., Fröhling, S., Heilig, C.E.

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487P Randomized phase II study of trabectedin/olaparib compared to physician’s choice in subjects with previously treated advanced or recurrent solid tumors harboring DNA repair de... von Heilig, C.E., Teleanu, M-V., Bhatti, I.A., Richter, S., Siveke, J.T., Wagner, S., Kopp, H-G., Kindler, T., Illert, L., Golf, A., Dormann, K., Benner, A., Süsse, H., Freitag, A., Von Kalle, C., Glimm, H., Hübschmann, D., Fröhling, S., Schlenk, R.F.

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6P Combined single-cell and spatially resolved mapping of the human lymph node ecosystem reveals fundamental principles of lymphoma tissue organization von Hübschmann, D., Jopp-Saile, L., Czernilofsky, F., Mathioudaki, A., Lutz, R., Vonficht, D., Wang, X., Baertsch, M.A., Vöhringer, H., Roider, T., Mammen, J., Ordoñez-Rueda, D., Pabst, C., Huber, W., Trumpp, A., Müller-Tidow, C., Nolan, G., Zaugg, J., Haas, S., Dietrich, S.

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1940P Deep molecular profiling of advanced synovial sarcoma as a basis for interventional clinical trials von Schlenk, R.F., Oleś, M., Bauer, S., Kindler, T., Klauschen, F., Brandts, C.H., Rieke, D.T., Illert, L., Börries, M., Heining, C., Horak, P., Bitzer, M., Dirksen, U., Sparber-Sauer, M., Teleanu, M-V., Kreutzfeldt, S., Glimm, H., Hübschmann, D., Heilig, C.E., Fröhling, S.

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187P Ipatasertib and atezolizumab in cancers with increased PI3K-AKT pathway activity: First results from the CRAFT trial von Heilig, C.E., Singh, M., Teleanu, M-V., Desuki, A., Kindler, T., Bitzer, M., Baier, B.D., Kunzmann, V., von Bubnoff, N., Süsse, H., Heiligenthal, L., Steindorf, K., Benner, A., Kreutzfeldt, S., Heining, C., Horak, P., Hübschmann, D., Glimm, H., Fröhling, S., Schlenk, R.F.

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