Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer von Senkowski, Wojciech, Zhang, Xiaonan, Olofsson, Maria Hägg, Isacson, Ruben, Höglund, Urban, Gustafsson, Mats, Nygren, Peter, Linder, Stig, Larsson, Rolf, Fryknäs, Mårten

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Inhibition of proteasome deubiquitinating activity as a new cancer therapy von D'Arcy, Pádraig, Brnjic, Slavica, Olofsson, Maria Hägg, Fryknäs, Mårten, Lindsten, Kristina, De Cesare, Michelandrea, Perego, Paola, Sadeghi, Behnam, Hassan, Moustapha, Larsson, Rolf, Linder, Stig

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Cytokeratin-18 Is a Useful Serum Biomarker for Early Determination of Response of Breast Carcinomas to Chemotherapy von HÄGG OLOFSSON, Maria, UENO, Takayuki, ANDERSSON, Elina, SHOSHAN, Maria C, MANDIC HAVELKA, Aleksandra, TOI, Masakazu, LINDER, Stig, YANG PAN, REN XU, FENG CAI, VAN DER KUIP, Heiko, MUERDTER, Thomas E, SONNENBERG, Maike, AULITZKY, Walter E, SCHWARZ, Stephan

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Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors von Zhang, Xiaonan, de Milito, Angelo, Olofsson, Maria Hägg, Gullbo, Joachim, D'Arcy, Padraig, Linder, Stig

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Iron chelators target both proliferating and quiescent cancer cells von Fryknäs, Mårten, Zhang, Xiaonan, Bremberg, Ulf, Senkowski, Wojciech, Olofsson, Maria Hägg, Brandt, Peter, Persson, Ingmar, D’Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Schughart, Leoni Kunz, Linder, Stig, Larsson, Rolf

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MYC is downregulated by a mitochondrial checkpoint mechanism von Zhang, Xiaonan, Mofers, Arjan, Hydbring, Per, Olofsson, Maria Hägg, Guo, Jing, Linder, Stig, D'Arcy, Padraig

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Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition von Mazurkiewicz, Magdalena, Hillert, Ellin-Kristina, Wang, Xin, Pellegrini, Paola, Olofsson, Maria Hägg, Selvaraju, Karthik, D'Arcy, Padraig, Linder, Stig

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The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells von Wang, Xin, Mazurkiewicz, Magdalena, Hillert, Ellin-Kristina, Olofsson, Maria Hägg, Pierrou, Stefan, Hillertz, Per, Gullbo, Joachim, Selvaraju, Karthik, Paulus, Aneel, Akhtar, Sharoon, Bossler, Felicitas, Khan, Asher Chanan, Linder, Stig, D’Arcy, Padraig

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Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters von Fayad, Walid, Fryknäs, Mårten, Brnjic, Slavica, Olofsson, Maria Hägg, Larsson, Rolf, Linder, Stig

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Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three‐dimensional carcinoma culture model von Fayad, Walid, Brnjic, Slavica, Berglind, Daniel, Blixt, Susanna, Shoshan, Maria C., Berndtsson, Maria, Olofsson, Maria Hägg, Linder, Stig

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Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties von Fayad, Walid, Rickardson, Linda, Haglund, Caroline, Olofsson, Maria Hägg, D'Arcy, Padraig, Larsson, Rolf, Linder, Stig, Fryknäs, Mårten

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Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy von Stafford, WC, Peng, XX, Olofsson, MH, Zhang, XN, Luci, DK, Lu, L, Cheng, Q, Tresaugues, L, Dexheimer, TS, Coussens, NP, Augsten, M, Ahlzen, HSM, Orwar, O, Ostman, A, Stone-Elander, S, Maloney, DJ, Jadhav, A, Simeonov, A, Linder, S, Arner, ESJ

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Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats von Samén, Erik, Arnberg, Fabian, Lu, Li, Olofsson, Maria Hägg, Tegnebratt, Tetyana, Thorell, Jan-Olov, Holmin, Staffan, Stone-Elander, Sharon

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Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis von Brnjic, Slavica, Olofsson, Maria Hägg, Havelka, Aleksandra Mandic, Linder, Stig

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Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments von Zhang, Xiaonan, Fryknäs, Mårten, Hernlund, Emma, Fayad, Walid, De Milito, Angelo, Olofsson, Maria Hägg, Gogvadze, Vladimir, Dang, Long, Påhlman, Sven, Schughart, Leoni A. Kunz, Rickardson, Linda, D′Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Larsson, Rolf, Linder, Stig

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Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell de... von Cheng, Qing, Lu, Li, Grafström, Jonas, Hägg Olofsson, Maria, Thorell, Jan-Olov, Samén, Erik, Johansson, Katarina, Ahlzén, Hanna-Stina, Linder, Stig, Arnér, Elias S.J., Stone-Elander, Sharon

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The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy von Hernlund, Emma, Olofsson, Maria Hägg, Fayad, Walid, Fryknäs, Mårten, Lesiak-Mieczkowska, Karolina, Zhang, Xiaonan, Brnjic, Slavica, Schmidt, Vivien, D’Arcy, Padraig, Sjöblom, Tobias, Milito, Angelo De, Larsson, Rolf, Linder, Stig

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The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage von Zhang, Xiaonan, Pellegrini, Paola, Saei, Amir Ata, Hillert, Ellin-Kristina, Mazurkiewicz, Magdalena, Olofsson, Maria Hägg, Zubarev, Roman A., D'Arcy, Pádraig, Linder, Stig

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Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II von Olofsson, Maria Hägg, Havelka, Aleksandra Mandic, Brnjic, Slavica, Shoshan, Maria C, Linder, Stig

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Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells von Pellegrini, Paola, Dyczynski, Matheus, Sbrana, Francesca Vittoria, Karlgren, Maria, Buoncervello, Maria, Hägg-Olofsson, Maria, Ma, Ran, Hartman, Johan, Bajalica-Lagercrantz, Svetlana, Grander, Dan, Kharaziha, Pedram, De Milito, Angelo

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