Rapid repurposing of drugs for COVID-19 von Guy, R Kiplin, DiPaola, Robert S, Romanelli, Frank, Dutch, Rebecca E

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CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss von Teitz, Tal, Fang, Jie, Goktug, Asli N, Bonga, Justine D, Diao, Shiyong, Hazlitt, Robert A, Iconaru, Luigi, Morfouace, Marie, Currier, Duane, Zhou, Yinmei, Umans, Robyn A, Taylor, Michael R, Cheng, Cheng, Min, Jaeki, Freeman, Burgess, Peng, Junmin, Roussel, Martine F, Kriwacki, Richard, Guy, R Kiplin, Chen, Taosheng, Zuo, Jian

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Inactivation of the p53 pathway in retinoblastoma von LAURIE, Nikia A, DONOVAN, Stacy L, JOHNSON, Dianna, WILSON, Matthew, RODRIGUEZ-GALINDO, Carlos, QUARTO, Micaela, FRANCOZ, Sarah, MENDRYSA, Susan M, KIPLIN GUY, R, MARINE, Jean-Christophe, JOCHEMSEN, Aart G, DYER, Michael A, SHIH, Chie-Schin, JIAKUN ZHANG, MILLS, Nicholas, FULLER, Christine, TEUNISSE, Amina, LAM, Suzanne, RAMOS, Yolande, MOHAN, Adithi

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Pemetrexed and Gemcitabine as Combination Therapy for the Treatment of Group3 Medulloblastoma von Morfouace, Marie, Shelat, Anang, Jacus, Megan, Freeman, Burgess B., Turner, David, Robinson, Sarah, Zindy, Frederique, Wang, Yong-Dong, Finkelstein, David, Ayrault, Olivier, Bihannic, Laure, Puget, Stephanie, Li, Xiao-Nan, Olson, James M., Robinson, Giles W., Guy, R. Kiplin, Stewart, Clinton F., Gajjar, Amar, Roussel, Martine F.

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Synthesis and biological evaluation of 4,7,9-trisubstituted benzoxazepines as antileishmanial agents von Kadayat, Tara Man, Kwiatkowski, Stefan, Ortiz, Diana, Shoeran, Gaurav, Hammill, Jared T., Kim, Ho Shin, Cholewo, Joanna, Landfear, Scott M., Kiplin Guy, R.

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Chemical genetics of Plasmodium falciparum von Guy, R. Kiplin, Guiguemde, W. Armand, Shelat, Anang A, Bouck, David, Duffy, Sandra, Crowther, Gregory J, Davis, Paul H, Smithson, David C, Connelly, Michele, Clark, Julie, Zhu, Fangyi, Jiménez-Díaz, María B, Martinez, María S, Wilson, Emily B, Tripathi, Abhai K, Gut, Jiri, Sharlow, Elizabeth R, Bathurst, Ian, Mazouni, Farah El, Fowble, Joseph W, Forquer, Isaac, McGinley, Paula L, Castro, Steve, Angulo-Barturen, Iñigo, Ferrer, Santiago, Rosenthal, Philip J, DeRisi, Joseph L, Sullivan, David J, Lazo, John S, Roos, David S, Riscoe, Michael K, Phillips, Margaret A, Rathod, Pradipsinh K, Van Voorhis, Wesley C, Avery, Vicky M

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A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML von Drenberg, Christina D., Shelat, Anang, Dang, Jinjun, Cotton, Anitria, Orwick, Shelley J., Li, Mengyu, Jeon, Jae Yoon, Fu, Qiang, Buelow, Daelynn R., Pioso, Marissa, Hu, Shuiying, Inaba, Hiroto, Ribeiro, Raul C., Rubnitz, Jeffrey E., Gruber, Tanja A., Guy, R. Kiplin, Baker, Sharyn D.

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Scaffold composition and biological relevance of screening libraries von Guy, R Kiplin, Shelat, Anang A

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Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer von Slavish, P Jake, Chi, Liying, Yun, Mi-Kyung, Tsurkan, Lyudmila, Martinez, Nancy E, Jonchere, Barbara, Chai, Sergio C, Connelly, Michele, Waddell, M Brett, Das, Sourav, Neale, Geoffrey, Li, Zhenmei, Shadrick, William R, Olsen, Rachelle R, Freeman, Kevin W, Low, Jonathan A, Price, Jeanine E, Young, Brandon M, Bharatham, Nagakumar, Boyd, Vincent A, Yang, Jun, Lee, Richard E, Morfouace, Marie, Roussel, Martine F, Chen, Taosheng, Savic, Daniel, Guy, R Kiplin, White, Stephen W, Shelat, Anang A, Potter, Philip M

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Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation von Hammill, Jared T, Bhasin, Deepak, Scott, Daniel C, Min, Jaeki, Chen, Yizhe, Lu, Yan, Yang, Lei, Kim, Ho Shin, Connelly, Michele C, Hammill, Courtney, Holbrook, Gloria, Jeffries, Cynthia, Singh, Bhuvanesh, Schulman, Brenda A, Guy, R. Kiplin

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Monitoring Ligand-Induced Protein Ordering in Drug Discovery von Grace, Christy R., Ban, David, Min, Jaeki, Mayasundari, Anand, Min, Lie, Finch, Kristin E., Griffiths, Lyra, Bharatham, Nagakumar, Bashford, Donald, Kiplin Guy, R., Dyer, Michael A., Kriwacki, Richard W.

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Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT) von Carrillo, Angela K., Guiguemde, W. Armand, Guy, R. Kiplin

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Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors von Shadrick, William R., Slavish, Peter J., Chai, Sergio C., Waddell, Brett, Connelly, Michele, Low, Jonathan A., Tallant, Cynthia, Young, Brandon M., Bharatham, Nagakumar, Knapp, Stefan, Boyd, Vincent A., Morfouace, Marie, Roussel, Martine F., Chen, Taosheng, Lee, Richard E., Kiplin Guy, R., Shelat, Anang A., Potter, Philip M.

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Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein von Eagon, Scott, Hammill, Jared T., Bach, Jordan, Everson, Nikalet, Sisley, Tyler A., Walls, Michael J., Durham, Sierra, Pillai, Dylan R., Falade, Mofolusho O., Rice, Amy L., Kimball, Joshua J., Lazaro, Horacio, DiBernardo, Celine, Kiplin Guy, R.

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Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening von Lack, Nathan A, Axerio-Cilies, Peter, Tavassoli, Peyman, Han, Frank Q, Chan, Ka Hong, Feau, Clementine, LeBlanc, Eric, Guns, Emma Tomlinson, Guy, R. Kiplin, Rennie, Paul S, Cherkasov, Artem

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Diverse amide analogs of sulindac for cancer treatment and prevention von Mathew, Bini, Hobrath, Judith V., Connelly, Michele C., Kiplin Guy, R., Reynolds, Robert C.

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Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio-thienopyrimidine (TTP) series of antimalarials von Barrows, Robert D., Hammill, Jared T., Tran, Michael C., Falade, Mofolusho O., Rice, Amy L., Davis, Christopher W., Emge, Thomas J., Rablen, Paul R., Kiplin Guy, R., Knapp, Spencer

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Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia von Kamens, Jennifer L., Nance, Stephanie, Koss, Cary, Xu, Beisi, Cotton, Anitria, Lam, Jeannie W., Garfinkle, Elizabeth A. R., Nallagatla, Pratima, Smith, Amelia M. R., Mitchell, Sharnise, Ma, Jing, Currier, Duane, Wright, William C., Kavdia, Kanisha, Pagala, Vishwajeeth R., Kim, Wonil, Wallace, LaShanale M., Cho, Ji-Hoon, Fan, Yiping, Seth, Aman, Twarog, Nathaniel, Choi, John K., Obeng, Esther A., Hatley, Mark E., Metzger, Monika L., Inaba, Hiroto, Jeha, Sima, Rubnitz, Jeffrey E., Peng, Junmin, Chen, Taosheng, Shelat, Anang A., Guy, R. Kiplin, Gruber, Tanja A.

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Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening von Ortiz, Diana, Guiguemde, W Armand, Hammill, Jared T, Carrillo, Angela K, Chen, Yizhe, Connelly, Michele, Stalheim, Kayla, Elya, Carolyn, Johnson, Alex, Min, Jaeki, Shelat, Anang, Smithson, David C, Yang, Lei, Zhu, Fangyi, Guy, R Kiplin, Landfear, Scott M

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Identification and Characterization of the First Small Molecule Inhibitor of MDMX von Reed, Damon, Shen, Ying, Shelat, Anang A., Arnold, Leggy A., Ferreira, Antonio M., Zhu, Fangyi, Mills, Nicholas, Smithson, David C., Regni, Catherine A., Bashford, Donald, Cicero, Samantha A., Schulman, Brenda A., Jochemsen, Aart G., Guy, R. Kiplin, Dyer, Michael A.

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