Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK -Fusion Positive Pediatric High-Grade Glioma von Mayr, Lisa, Guntner, Armin S, Madlener, Sibylle, Schmook, Maria T, Peyrl, Andreas, Azizi, Amedeo A, Dieckmann, Karin, Reisinger, Dominik, Stepien, Natalia M, Schramm, Kathrin, Laemmerer, Anna, Jones, David T W, Ecker, Jonas, Sahm, Felix, Milde, Till, Pajtler, Kristian W, Blattner-Johnson, Mirjam, Strbac, Miroslav, Dorfer, Christian, Czech, Thomas, Kirchhofer, Dominik, Gabler, Lisa, Berger, Walter, Haberler, Christine, Müllauer, Leonhard, Buchberger, Wolfgang, Slavc, Irene, Lötsch-Gojo, Daniela, Gojo, Johannes

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Abstract 5719: Clinical response to the PDGFRα inhibitor avapritinib in high-grade glioma patients von Mayr, Lisa, Trissal, Maria, Schwark, Kallen, Labelle, Jenna, Groves, Andrew, Furtner-Srajer, Julia, Supko, Jeffrey, Weiler-Wichtl, Liesa, Hack, Olivia, Rozowsky, Jacob, Marques, Joana G., Pandatharatna, Eshini, Leiss, Ulrike, Rosenmayr, Verena, Dubois, Frank, Greenwald, Noah F., Madlener, Sibylle, Guntner, Armin S., Pálová, Hana, Stepien, Natalia, Lötsch-Gojo, Daniela, Dorfer, Christian, Dieckmann, Karin, Peyrl, Andreas, Azizi, Amedeo A., Baumgartner, Alicia, Slabý, Ondřej, Pokorná, Petra, Bandopadhayay, Pratiti, Beroukhim, Rameen, Ligon, Keith, Kramm, Christof, Bronsema, Annika, Bailey, Simon, Stücklin, Ana Guerreiro, Mueller, Sabine, Jones, David T., Jäger, Natalie, Štěrba, Jaroslav, Müllauer, Leonhard, Haberler, Christine, Kumar-Sinha, Chandan, Chinnaiyan, Arul, Mody, Rajen, Skrypek, Mary, Martinez, Nina, Bowers, Daniel C., Koschmann, Carl, Gojo, Johannes, Filbin, Mariella

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Simultaneous analysis of quaternary ammonium cations and corresponding halide counterions by pyrolysis gas chromatography / mass spectrometry von Thalhamer, Bernhard, Guntner, Armin Sebastian, Buchberger, Wolfgang

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Collision cross sections obtained with ion mobility mass spectrometry as new descriptor to predict blood-brain barrier permeation by drugs von Guntner, Armin Sebastian, Thalhamer, Bernhard, Klampfl, Christian, Buchberger, Wolfgang

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Cerebrospinal fluid penetration of targeted therapeutics in pediatric brain tumor patients von Guntner, Armin Sebastian, Peyrl, Andreas, Mayr, Lisa, Englinger, Bernhard, Berger, Walter, Slavc, Irene, Buchberger, Wolfgang, Gojo, Johannes

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Large-Scale Evaluation of Collision Cross Sections to Investigate Blood-Brain Barrier Permeation of Drugs von Guntner, Armin Sebastian, Bögl, Thomas, Mlynek, Franz, Buchberger, Wolfgang

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Development of a highly sensitive gas chromatography–mass spectrometry method preceded by solid‐phase microextraction for the analysis of propofol in low‐volume cerebral microdialy... von Guntner, Armin Sebastian, Stöcklegger, Simon, Kneidinger, Michael, Illievich, Udo, Buchberger, Wolfgang

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Quantitative analysis of human brain microdialysate for target site pharmacokinetics of major anesthetics ketamine, midazolam and propofol von Guntner, Armin Sebastian, Buchberger, Wolfgang, Hosmann, Arthur, Mercea, Petra Andreea, Koren, Johannes, Reinprecht, Andrea, Zeitlinger, Markus, Herta, Johannes

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HPLC-MS/MS Shows That the Cellular Uptake of All-Trans-Retinoic Acid under Hypoxia Is Downregulated by the Novel Active Agent 5-Methoxyleoligin von Guntner, Armin Sebastian, Doppler, Christian, Wechselberger, Christian, Bernhard, David, Buchberger, Wolfgang

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DIPG-60. Avapritinib for targeting PDGFRA in H3K27M – mutated diffuse midline glioma von Mayr, Lisa, Madlener, Sibylle, Weiler-Wichtl, Liesa, Rosenmayr, Verena, Furtner-Srajer, Julia, Guntner, Armin, Stepien, Natalia, Baumgartner, Alicia-Christina, Dorfer, Christian, Haberler, Christine, Müllauer, Leonhard, Palova, Hana, Pokorna, Petra, Sterba, Jaroslav, Dieckmann, Karin, Azizi, Amedeo, Peyrl, Andreas, Kim, Sean, Hsieh, Antony, Dimitrijevic, Sasa, Gojo, Johannes

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DDDR-17. CLINICAL RESPONSE TO THE PDGFRA/KIT INHIBITOR AVAPRITINIB IN PEDIATRIC AND YOUNG ADULT HIGH-GRADE GLIOMA PATIENTS von Mayr, Lisa, Trissal, Maria, Schwark, Kallen, Neyazi, Sina, Beck, Alexander, Labelle, Jenna, Marques, Joana Graca, Weiler-Wichtl, Liesa, Madlener, Sibylle, Kong, Seongbae, Miclea, Madeline, Supko, Jeffrey, Guntner, Armin Sebastian, Palova, Hana, Neradil, Jakub, Stepien, Natalia, Loetsch-Gojo, Daniela, Dorfer, Christian, Dieckmann, Karen, Peyrl, Andreas, Azizi, Amedeo A, Baumgartner, Alicia-Christina, Slaby, Ondrej, Pokorna, Petra, Dubois, Frank, Greenwald, Noah, Bandopadhayay, Pratiti, Beroukhim, Rameen, Ligon, Keith, Kramm, Christof, Bronsema, Annika, Bailey, Simon, Stuecklin, Ana Guerreiro, Mueller, Sabine, Skrypek, Mary, Martinez, Nina, Bowers, Daniel C, Jones, David, Jones, Chris, Jaeger, Natalie, Sterba, Jaroslav, Müllauer, Leonhard, Haberler, Christine, Kumar-Sinha, Chandan, Chinnaiyan, Arul, Mody, Rajen, Furtner-Srajer, Julia, Koschmann, Carl, Gojo, Johannes, Filbin, Mariella

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DDDR-22. TRANSLATION OF THE PDGFRA/KIT INHIBITOR AVAPRITINIB FOR PEDIATRIC HIGH-GRADE GLIOMA von Mayr, Lisa, Trissal, Maria, Schwark, Kallen, Labelle, Jenna, Kong, Seongbae, Groves, Andrew, Supko, Jeffrey, Hack, Olivia, Marques, Joana, Panditharatna, Eshini, Dubois, Frank, Greenwald, Noah, Bandopadhayay, Pratiti, Ligon, Keith, Furtner-Srajer, Julia, Weiler-Wichtl, Liesa, Leiss, Ulrike, Rosenmayr, Verena, Madlener, Sibylle, Stepien, Natalia, Lötsch-Gojo, Daniela, Dorfer, Christian, Dieckmann, Karin, Azizi, Amedeo, Guntner, Armin, Palova, Hana, Slaby, Ondrej, Pokorná, Petra, Beroukhim, Rameen, Kramm, Christof, Jones, David T, Štěrba, Jaroslav, Mullauer, Leonhard, Haberler, Christine, Perez, Nisha, Kim, Sean, Hsieh, Anthony, Dimitrijevic, Sasa, Skrypek, Mary, Martinez, Nina, Bowers, Daniel, Filbin, Mariella, Gojo, Johannes, Koschmann, Carl

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HGG-19. CLINICAL RESPONSE TO THE PDGFRA/KIT INHIBITOR AVAPRITINIB IN PEDIATRIC AND YOUNG ADULT HIGH-GRADE GLIOMA PATIENTS WITH H3K27M OR PDGFRA GENOMIC ALTERATIONS von Trissal, Maria, Mayr, Lisa, Schwark, Kallen, LaBelle, Jenna, Kong, Seongbae, Furtner, Julia, Weiler-Wichtl, Liesa, Supko, Jeffrey, Rozowsky, Jacob, Hack, Olivia, Groves, Andrew, Marques, Joana, Leiss, Ulrike, Rosenmayr, Verena, Dubois, Frank, Greenwald, Noah F, Madlener, Sibylle, Guntner, Armin Sebastian, Pálová, Hana, Stepien, Natalia, Lötsch-Gojo, Daniela, Dorfer, Christian, Dieckmann, Karen, Peyrl, Andreas, Azizi, Amadeo A, Baumgartner, Alicia, Slabý, Ondřej, Pokorná, Petra, Bandopadhayay, Pratiti, Rameen_Beroukhim@dfci.harvard.edu Beroukhim, Rameen Beroukhim, Ligon, Keith L, Kramm, Christof M, Bronsema, Annika, Bailey, Simon, Stucklin, Ana Guerreiro, Mueller, Sabine Mueller, Jones, David T W, Jäger, Natalie, Mullauer, Leonhard, Haberler, Christine, Kumar-Sinha, Chandan, Chinnaiyan, Arul, Mody, Rajen, Sterba.Jaroslav@fnbrno.cz Štěrba, Jaroslav Štěrba, Skrypek, Mary, Martinez, Nina, Bowers, Daniel C, Koschmann, Carl Koschmann, Gojo, Johannes, Filbin, Mariella

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