Systematic gene tagging using CRISPR/Cas9 in human stem cells to illuminate cell organization von Roberts, Brock, Haupt, Amanda, Tucker, Andrew, Grancharova, Tanya, Arakaki, Joy, Fuqua, Margaret A, Nelson, Angelique, Hookway, Caroline, Ludmann, Susan A, Mueller, Irina A, Yang, Ruian, Horwitz, Rick, Rafelski, Susanne M, Gunawardane, Ruwanthi N

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AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML) von Zarrinkar, Patrick P., Gunawardane, Ruwanthi N., Cramer, Merryl D., Gardner, Michael F., Brigham, Daniel, Belli, Barbara, Karaman, Mazen W., Pratz, Keith W., Pallares, Gabriel, Chao, Qi, Sprankle, Kelly G., Patel, Hitesh K., Levis, Mark, Armstrong, Robert C., James, Joyce, Bhagwat, Shripad S.

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A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes von Grancharova, Tanya, Gerbin, Kaytlyn A., Rosenberg, Alexander B., Roco, Charles M., Arakaki, Joy E., DeLizo, Colette M., Dinh, Stephanie Q., Donovan-Maiye, Rory M., Hirano, Matthew, Nelson, Angelique M., Tang, Joyce, Theriot, Julie A., Yan, Calysta, Menon, Vilas, Palecek, Sean P., Seelig, Georg, Gunawardane, Ruwanthi N.

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PDEF Promotes Luminal Differentiation and Acts as a Survival Factor for ER-Positive Breast Cancer Cells von Buchwalter, Gilles, Hickey, Michele M., Cromer, Anne, Selfors, Laura M., Gunawardane, Ruwanthi N., Frishman, Jason, Jeselsohn, Rinath, Lim, Elgene, Chi, David, Fu, Xiaoyong, Schiff, Rachel, Brown, Myles, Brugge, Joan S.

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It’s time to incorporate diversity into our basic science and disease models von Horwitz, Rick, Riley, Ekemini A. U., Millan, Maria T., Gunawardane, Ruwanthi N.

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MYC Regulation of a "Poor-Prognosis" Metastatic Cancer Cell State von Wolfer, Anita, Wittner, Ben S., Irimia, Daniel, Flavin, Richard J., Lupien, Mathieu, Gunawardane, Ruwanthi N., Meyer, Clifford A., Lightcap, Eric S., Tamayo, Pablo, Mesirov, Jill P., Liu, X. Shirley, Shioda, Toshi, Toner, Mehmet, Loda, Massimo, Brown, Myles, Brugge, Joan S., Ramaswamy, Sridhar

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Abstract 111: Conjoining Gene Expression And Cell Organization With Imaging To Explore Cell States In Hipsc-derived Cardiomyocytes von Gunawardane, Ruwanthi

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Automated human induced pluripotent stem cell culture and sample preparation for 3D live-cell microscopy von Gregor, Benjamin W., Coston, Mackenzie E., Adams, Ellen M., Arakaki, Joy, Borensztejn, Antoine, Do, Thao P., Fuqua, Margaret A., Haupt, Amanda, Hendershott, Melissa C., Leung, Winnie, Mueller, Irina A., Nath, Aditya, Nelson, Angelique M., Rafelski, Susanne M., Sanchez, Emmanuel E., Swain-Bowden, Madison J., Tang, W. Joyce, Thirstrup, Derek J., Wiegraebe, Winfried, Whitney, Brian P., Yan, Calysta, Gunawardane, Ruwanthi N., Gaudreault, Nathalie

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Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration von Lee, Soah, Vander Roest, Alison S, Blair, Cheavar A, Kao, Kerry, Bremner, Samantha B, Childers, Matthew C, Pathak, Divya, Heinrich, Paul, Lee, Daniel, Chirikian, Orlando, Mohran, Saffie E, Roberts, Brock, Smith, Jacqueline E, Jahng, James W, Paik, David T, Wu, Joseph C, Gunawardane, Ruwanthi N, Ruppel, Kathleen M, Mack, David L, Pruitt, Beth L, Regnier, Michael, Wu, Sean M, Spudich, James A, Bernstein, Daniel

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Fluorescent Gene Tagging of Transcriptionally Silent Genes in hiPSCs von Roberts, Brock, Hendershott, Melissa C., Arakaki, Joy, Gerbin, Kaytlyn A., Malik, Haseeb, Nelson, Angelique, Gehring, Jamie, Hookway, Caroline, Ludmann, Susan A., Yang, Ruian, Haupt, Amanda, Grancharova, Tanya, Valencia, Veronica, Fuqua, Margaret A., Tucker, Andrew, Rafelski, Susanne M., Gunawardane, Ruwanthi N.

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The high-resolution crystal structure of human LCAT von Piper, Derek E, Romanow, William G, Gunawardane, Ruwanthi N, Fordstrom, Preston, Masterman, Stephanie, Pan, Oscar, Thibault, Stephen T, Zhang, Richard, Meininger, David, Schwarz, Margrit, Wang, Zhulun, King, Chadwick, Zhou, Mingyue, Walker, Nigel P C

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Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Sele... von Chao, Qi, Sprankle, Kelly G, Grotzfeld, Robert M, Lai, Andiliy G, Carter, Todd A, Velasco, Anne Marie, Gunawardane, Ruwanthi N, Cramer, Merryl D, Gardner, Michael F, James, Joyce, Zarrinkar, Patrick P, Patel, Hitesh K, Bhagwat, Shripad S

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Endogenous Protein Tagging in Human Induced Pluripotent Stem Cells Using CRISPR/Cas9 von Haupt, Amanda, Grancharova, Tanya, Arakaki, Joy, Fuqua, Margaret A, Roberts, Brock, Gunawardane, Ruwanthi N

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Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism von Gunawardane, Ruwanthi N., Fordstrom, Preston, Piper, Derek E., Masterman, Stephanie, Siu, Sophia, Liu, Dongming, Brown, Mike, Lu, Mei, Tang, Jie, Zhang, Richard, Cheng, Janet, Gates, Andrew, Meininger, David, Chan, Joyce, Carlson, Tim, Walker, Nigel, Schwarz, Margrit, Delaney, John, Zhou, Mingyue

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Transient exposure to quizartinib mediates sustained inhibition of FLT3 signaling while specifically inducing apoptosis in FLT3-activated leukemia cells von Gunawardane, Ruwanthi N, Nepomuceno, Ronald R, Rooks, Allison M, Hunt, Jeremy P, Ricono, Jill M, Belli, Barbara, Armstrong, Robert C

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Cell states beyond transcriptomics: Integrating structural organization and gene expression in hiPSC-derived cardiomyocytes von Gerbin, Kaytlyn A., Grancharova, Tanya, Donovan-Maiye, Rory M., Hendershott, Melissa C., Anderson, Helen G., Brown, Jackson M., Chen, Jianxu, Dinh, Stephanie Q., Gehring, Jamie L., Johnson, Gregory R., Lee, HyeonWoo, Nath, Aditya, Nelson, Angelique M., Sluzewski, M. Filip, Viana, Matheus P., Yan, Calysta, Zaunbrecher, Rebecca J., Cordes Metzler, Kimberly R., Gaudreault, Nathalie, Knijnenburg, Theo A., Rafelski, Susanne M., Theriot, Julie A., Gunawardane, Ruwanthi N.

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Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally E... von Rowbottom, Martin W, Faraoni, Raffaella, Chao, Qi, Campbell, Brian T, Lai, Andiliy G, Setti, Eduardo, Ezawa, Maiko, Sprankle, Kelly G, Abraham, Sunny, Tran, Lan, Struss, Brian, Gibney, Michael, Armstrong, Robert C, Gunawardane, Ruwanthi N, Nepomuceno, Ronald R, Valenta, Ianina, Hua, Helen, Gardner, Michael F, Cramer, Merryl D, Gitnick, Dana, Insko, Darren E, Apuy, Julius L, Jones-Bolin, Susan, Ghose, Arup K, Herbertz, Torsten, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce, Williams, Michael, Bhagwat, Shripad, James, Joyce, Holladay, Mark W

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CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity von James, Joyce, Ruggeri, Bruce, Armstrong, Robert C, Rowbottom, Martin W, Jones-Bolin, Susan, Gunawardane, Ruwanthi N, Dobrzanski, Pawel, Gardner, Michael F, Zhao, Hugh, Cramer, Merryl D, Hunter, Kathryn, Nepomuceno, Ronald R, Cheng, Mangeng, Gitnick, Dana, Yazdanian, Mehran, Insko, Darren E, Ator, Mark A, Apuy, Julius L, Faraoni, Raffaella, Dorsey, Bruce D, Williams, Michael, Bhagwat, Shripad S, Holladay, Mark W

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The high-resolution crystal structure of human LCAT1 von Piper, Derek E., Romanow, William G., Gunawardane, Ruwanthi N., Fordstrom, Preston, Masterman, Stephanie, Pan, Oscar, Thibault, Stephen T., Zhang, Richard, Meininger, David, Schwarz, Margrit, Wang, Zhulun, King, Chadwick, Zhou, Mingyue, Walker, NigelP.C.

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Novel role for PDEF in epithelial cell migration and invasion von GUNAWARDANE, Ruwanthi N, SGROI, Dennis C, WROBEL, Carolyn N, KOH, Eugene, DALEY, George Q, BRUGGE, Joan S

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