F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity von Kruczynski, A, Pillon, A, Créancier, L, Vandenberghe, I, Gomes, B, Brel, V, Fournier, E, Annereau, J-P, Currie, E, Guminski, Y, Bonnet, D, Bailly, C, Guilbaud, N

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A fluorescent biomarker of the polyamine transport system to select patients with AML for F14512 treatment von Annereau, J.-P, Brel, V, Dumontet, C, Guminski, Y, Imbert, T, Broussas, M, Vispé, S, Bréand, S, Guilbaud, N, Barret, J.-M, Bailly, C

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111 POSTER Design of a screening procedure to select patients with leukemia for treatment with F 14512, a novel targeted cytotoxic agent von Barret, J.M, Annereau, J.P, Brel, V, Broussas, M, Guminski, Y, Imbert, T, Dumontet, C, Goetsch, L, Guilbaud, N, Bailly, C

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Use of chiral glycerol 2,3-carbonate in the synthesis of 3-aryl-2-oxazolidinones von Jegham, S., Nedelec, A., Burnier, Ph, Guminski, Y., Puech, F., Koenig, J.J., George, P.

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A functional procedure using fresh samples to select patients with acute myeloid leukemia prior to treatment with the novel targeted cytotoxic agent F14512 von Barret, J., Dumontet, C., Annereau, J., Brel, V., Breillout, F., Guminski, Y., Imbert, T., Guilbaud, N., Bailly, C.

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Synthesis and Antitumor Activity of New Glycosides of Epipodophyllotoxin, Analogues of Etoposide, and NK 611 von Daley, Laurent, Guminski, Yves, Demerseman, Pierre, Kruczynski, Anna, Etiévant, Chantal, Imbert, Thierry, Hill, Bridget T, Monneret, Claude

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F 11782, a dual inhibitor of topoisomerases I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumour activity, relative to three other dual... von ETIEVANT, C, KRUCZYNSKI, A, BARRET, J.-M, PERRIN, D, VAN HILLE, B, GUMINSKI, Y, HILL, B. T

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AN EFFICIENT SYNTHESIS OF MEQUITAZINE von Guminski, Yves, Fabre, Valerie, Lesimple, Patrick, Imbert, Thierry

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[125I]iodo-zacopride : un nouveau ligand pour l'étude par autoradiagraphic des récepteurs 5-HT3 centraux von KOSCIELNIAK, T, PONCHANT, M, LAPORTE, A.-M, GUMINSKI, Y, VERGE, D, HAMON, M, GOZLAN, H

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Dynamic Changes in PD-L1 Expression and Immune Infiltrates Early During Treatment Predict Response to PD-1 Blockade in Melanoma von Vilain, Ricardo E, Menzies, Alexander M, Wilmott, James S, Kakavand, Hojabr, Madore, Jason, Guminski, Alexander, Liniker, Elizabeth, Kong, Benjamin Y, Cooper, Adam J, Howle, Julie R, Saw, Robyn P M, Jakrot, Valerie, Lo, Serigne, Thompson, John F, Carlino, Matteo S, Kefford, Richard F, Long, Georgina V, Scolyer, Richard A

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NEW (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICAN... von IMBERT, THIERRY T, KRUCZYNSKI, ANNA A, BARRET, JEAN-MARC J-M, GUMINSKI, YVES Y

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Circulating Cytokines Predict Immune-Related Toxicity in Melanoma Patients Receiving Anti-PD-1-Based Immunotherapy von Lim, Su Y, Lee, Jenny H, Gide, Tuba N, Menzies, Alexander M, Guminski, Alexander, Carlino, Matteo S, Breen, Edmond J, Yang, Jean Y H, Ghazanfar, Shila, Kefford, Richard F, Scolyer, Richard A, Long, Georgina V, Rizos, Helen

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ChemInform Abstract: Use of Chiral Glycerol 2,3-Carbonate in the Synthesis of 3-Aryl-2-oxazolidinones von JEGHAM, S., NEDELEC, A., BURNIER, PH, GUMINSKI, Y., PUECH, F., KOENIG, J. J., GEORGE, P.

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Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy von Naidoo, Jarushka, Wang, Xuan, Woo, Kaitlin M, Iyriboz, Tunc, Halpenny, Darragh, Cunningham, Jane, Chaft, Jamie E, Segal, Neil H, Callahan, Margaret K, Lesokhin, Alexander M, Rosenberg, Jonathan, Voss, Martin H, Rudin, Charles M, Rizvi, Hira, Hou, Xue, Rodriguez, Katherine, Albano, Melanie, Gordon, Ruth-Ann, Leduc, Charles, Rekhtman, Natasha, Harris, Bianca, Menzies, Alexander M, Guminski, Alexander D, Carlino, Matteo S, Kong, Benjamin Y, Wolchok, Jedd D, Postow, Michael A, Long, Georgina V, Hellmann, Matthew D

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Standard-dose pembrolizumab in combination with reduced-dose ipilimumab for patients with advanced melanoma (KEYNOTE-029): an open-label, phase 1b trial von Long, Georgina V, Atkinson, Victoria, Cebon, Jonathan S, Jameson, Michael B, Fitzharris, Bernie M, McNeil, Catriona M, Hill, Andrew G, Ribas, Antoni, Atkins, Michael B, Thompson, John A, Hwu, Wen-Jen, Hodi, F Stephen, Menzies, Alexander M, Guminski, Alexander D, Kefford, Richard, Kong, Benjamin Y, Tamjid, Babak, Srivastava, Archana, Lomax, Anna J, Islam, Mohammed, Shu, Xinxin, Ebbinghaus, Scot, Ibrahim, Nageatte, Carlino, Matteo S

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(125I)iodo-zacopride: new ligand for the study by autoradiography of central 5-HT3 receptors von Koscielniak, T, Ponchant, M, Laporte, A M, Guminski, Y, Verge, D, Hamon, M, Gozlan, H

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[177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial von Hofman, Michael S, Emmett, Louise, Sandhu, Shahneen, Iravani, Amir, Joshua, Anthony M, Goh, Jeffrey C, Pattison, David A, Tan, Thean Hsiang, Kirkwood, Ian D, Ng, Siobhan, Francis, Roslyn J, Gedye, Craig, Rutherford, Natalie K, Weickhardt, Andrew, Scott, Andrew M, Lee, Sze-Ting, Kwan, Edmond M, Azad, Arun A, Ramdave, Shakher, Redfern, Andrew D, Macdonald, William, Guminski, Alex, Hsiao, Edward, Chua, Wei, Lin, Peter, Zhang, Alison Y, McJannett, Margaret M, Stockler, Martin R, Violet, John A, Williams, Scott G, Martin, Andrew J, Davis, Ian D, Azad, Arun A, Chua, Wei, Davis, Ian D, Dhiantravan, Nattakorn, Emmett, Louise, Ford, Kate, Hofman, Michael S, Francis, Roslyn J, Gedye, Craig, Goh, Jeffrey C, Guminski, Alex, Hsiao, Edward, Iravani, Amir, Joshua, Anthony M, Kirkwood, Ian D, Langford, Ailsa, Lawrence, Nicola, Lee, Sze-Ting, Lin, Peter, Martin, Andrew J, McDonald, William, McJannett, Margaret M, Ng, Siobhan, Pattison, David A, Ramdave, Shakher, Rana, Nisha, Redfern, Andrew D, Rutherford, Natalie K, Sandhu, Shahneen, Scott, Andrew M, Stockler, Martin R, Subramaniam, Shalini, Tan, Thean Hsiang, Violet, John A, Weickhardt, Andrew, Williams, Scott G, Yip, Sonia, Zhang, Alison Y

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Activity and safety of radiotherapy with anti-PD-1 drug therapy in patients with metastatic melanoma von Liniker, E., Menzies, A. M., Kong, B. Y., Cooper, A., Ramanujam, S., Lo, S., Kefford, R. F., Fogarty, G. B., Guminski, A., Wang, T. W., Carlino, M. S., Hong, A., Long, G. V.

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Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer von Smith, Matthew R, Saad, Fred, Chowdhury, Simon, Oudard, Stéphane, Hadaschik, Boris A, Graff, Julie N, Olmos, David, Mainwaring, Paul N, Lee, Ji Youl, Uemura, Hiroji, Lopez-Gitlitz, Angela, Trudel, Géralyn C, Espina, Byron M, Shu, Youyi, Park, Youn C, Rackoff, Wayne R, Yu, Margaret K, Small, Eric J

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Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer von Sternberg, Cora N, Fizazi, Karim, Saad, Fred, Shore, Neal D, De Giorgi, Ugo, Penson, David F, Ferreira, Ubirajara, Efstathiou, Eleni, Madziarska, Katarzyna, Kolinsky, Michael P, Cubero, Daniel I. G, Noerby, Bettina, Zohren, Fabian, Lin, Xun, Modelska, Katharina, Sugg, Jennifer, Steinberg, Joyce, Hussain, Maha

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