Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions von COOPER-KNOCK, Johnathan, WALSH, Matthew J, HAUTBERGUE, Guillaume M, SHAW, Pamela J, HIGGINBOTTOM, Adrian, HIGHLEY, J. Robin, DICKMAN, Mark J, EDBAUER, Dieter, INCE, Paul G, WHARTON, Stephen B, WILSON, Stuart A, KIRBY, Janine

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C9orf72 expansion disrupts ATM-mediated chromosomal break repair von Walker, Callum, Herranz-Martin, Saul, Karyka, Evangelia, Liao, Chunyan, Lewis, Katherine, Elsayed, Waheba, Lukashchuk, Vera, Chiang, Shih-Chieh, Ray, Swagat, Mulcahy, Padraig J, Jurga, Mateusz, Tsagakis, Ioannis, Iannitti, Tommaso, Chandran, Jayanth, Coldicott, Ian, De Vos, Kurt J, Hassan, Mohamed K, Higginbottom, Adrian, Shaw, Pamela J, Hautbergue, Guillaume M, Azzouz, Mimoun, El-Khamisy, Sherif F

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Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS von Varcianna, André, Myszczynska, Monika A., Castelli, Lydia M., O'Neill, Brendan, Kim, Yeseul, Talbot, Jordan, Nyberg, Sophie, Nyamali, Immanuelle, Heath, Paul R., Stopford, Matthew J., Hautbergue, Guillaume M., Ferraiuolo, Laura

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TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export von Viphakone, Nicolas, Hautbergue, Guillaume M., Walsh, Matthew, Chang, Chung-Te, Holland, Arthur, Folco, Eric G., Reed, Robin, Wilson, Stuart A.

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The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function von Mihaylov, Simeon R., Castelli, Lydia M., Lin, Ya-Hui, Gül, Aytac, Soni, Nikita, Hastings, Christopher, Flynn, Helen R., Păun, Oana, Dickman, Mark J., Snijders, Ambrosius P., Goldstone, Robert, Bandmann, Oliver, Shelkovnikova, Tatyana A., Mortiboys, Heather, Ultanir, Sila K., Hautbergue, Guillaume M.

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Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis von Benson, Bridget C, Shaw, Pamela J, Azzouz, Mimoun, Highley, J Robin, Hautbergue, Guillaume M

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Chtop is a component of the dynamic TREX mRNA export complex von Chang, Chung-Te, Hautbergue, Guillaume M, Walsh, Matthew J, Viphakone, Nicolas, van Dijk, Thamar B, Philipsen, Sjaak, Wilson, Stuart A

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A Simple Method for Improving Protein Solubility and Long-Term Stability von Golovanov, Alexander P, Hautbergue, Guillaume M, Wilson, Stuart A, Lian, Lu-Yun

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Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features von Shaw, Matthew P, Higginbottom, Adrian, McGown, Alexander, Castelli, Lydia M, James, Evlyn, Hautbergue, Guillaume M, Shaw, Pamela J, Ramesh, Tennore M

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The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations von Rust, Aleksander, Partridge, Lynda J, Davletov, Bazbek, Hautbergue, Guillaume M

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A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations von Allen, Scott P, Al Sultan, Afnan, Kabucho Kibirige, Elaine, Tonkiss, Erin, Hamer, Keaton J, Castelli, Lydia M, Lin, Ya-Hui, Roscoe, Sarah, Stefanidis, Nikolaos, Mead, Richard J, Highley, J Robin, Cooper-Knock, Johnathan, Hautbergue, Guillaume M, Heath, Paul R, Kirby, Janine, Shaw, Pamela J

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Competitive and cooperative interactions mediate RNA transfer from herpesvirus saimiri ORF57 to the mammalian export adaptor ALYREF von Tunnicliffe, Richard B, Hautbergue, Guillaume M, Wilson, Stuart A, Kalra, Priti, Golovanov, Alexander P

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Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells von Rust, Aleksander, Shah, Sajid, Hautbergue, Guillaume M, Davletov, Bazbek

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Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP von Hautbergue, Guillaume M, Hung, Ming-Lung, Golovanov, Alexander P, Lian, Lu-Yun, Wilson, Stuart A

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RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration von Castelli, Lydia M, Benson, Bridget C, Huang, Wan-Ping, Lin, Ya-Hui, Hautbergue, Guillaume M

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Structural basis for the recognition of cellular mRNA export factor REF by herpes viral proteins HSV-1 ICP27 and HVS ORF57 von Tunnicliffe, Richard B, Hautbergue, Guillaume M, Kalra, Priti, Jackson, Brian R, Whitehouse, Adrian, Wilson, Stuart A, Golovanov, Alexander P

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C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten von Stopford, Matthew J, Higginbottom, Adrian, Hautbergue, Guillaume M, Cooper-Knock, Johnathan, Mulcahy, Padraig J, De Vos, Kurt J, Renton, Alan E, Pliner, Hannah, Calvo, Andrea, Chio, Adriano, Traynor, Bryan J, Azzouz, Mimoun, Heath, Paul R, Kirby, Janine, Shaw, Pamela J

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Applications of machine learning to diagnosis and treatment of neurodegenerative diseases von Myszczynska, Monika A., Ojamies, Poojitha N., Lacoste, Alix M. B., Neil, Daniel, Saffari, Amir, Mead, Richard, Hautbergue, Guillaume M., Holbrook, Joanna D., Ferraiuolo, Laura

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SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis von Castelli, Lydia M, Cutillo, Luisa, Souza, Cleide Dos Santos, Sanchez-Martinez, Alvaro, Granata, Ilaria, Lin, Ya-Hui, Myszczynska, Monika A, Heath, Paul R, Livesey, Matthew R, Ning, Ke, Azzouz, Mimoun, Shaw, Pamela J, Guarracino, Mario R, Whitworth, Alexander J, Ferraiuolo, Laura, Milo, Marta, Hautbergue, Guillaume M

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Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS von Iannitti, Tommaso, Scarrott, Joseph M., Likhite, Shibi, Coldicott, Ian R.P., Lewis, Katherine E., Heath, Paul R., Higginbottom, Adrian, Myszczynska, Monika A., Milo, Marta, Hautbergue, Guillaume M., Meyer, Kathrin, Kaspar, Brian K., Ferraiuolo, Laura, Shaw, Pamela J., Azzouz, Mimoun

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