The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation von Gazanion, E., Garcia, D., Silvestre, R., Gérard, C., Guichou, J. F., Labesse, G., Seveno, M., Cordeiro‐Da‐Silva, A., Ouaissi, A., Sereno, D., Vergnes, B.

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TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM von Sabatier, Laurence, Guichou, Jean-François, Kohara, Yuji, Couillault, Carole, Ewbank, Jonathan J, Reboul, Jérôme, Pujol, Nathalie

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Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity von Loeuillet, C., Touquet, B., Oury, B., Eddaikra, N., Pons, J.L., Guichou, J.F., Labesse, G., Sereno, D.

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Strength and Character of Peptide/Anion Interactions von Chavanieu, A, Guichou, J. F, Prado-Gotor, R, Perez-Tejeda, P, Jimenez, R, Lopez-Cornejo, P, Sanchez, F

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1184 FRAGMENT BASED DRUG DISCOVERY OF NEW CYCLOPHILIN INHIBITORS UNRELATED TO CYCLOSPORINE A THAT POTENTLY INHIBIT HCV REPLICATION von Ahmed-Belkacem, A, Colliandre, L, Ahnou, N, Barthe, P, Bourget, W, Douguet, D, Guichou, J.-F, Pawlotsky, J.-M

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739 DISCOVERY OF A NOVEL, POTENT FLAVONOID INHIBITOR OF HCV RNA-DEPENDENT RNA POLYMERASE von Ahmed-Belkacem, A, Brillet, R, Pallier, C, Wychowski, C, Guichou, J.-F, Pawlotsky, J.-M

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1556PCirculating tumour DNA (ctDNA) analysis depicts mechanisms of resistance and tumour response to BRAF inhibitors in BRAF-mutant non-small cell lung cancer (NSCLC) von Ortiz - Cuaran, S, Mezquita, L, Swalduz, A, Aldea, M, Mazieres, J, Jovelet, C, Lacroix, L, Pradines, A, Avrillon, V, Mahier, C, Oukhatar, Aït, Hoog-Labouret, N, Howarth, K, Guichou, J-F, Morris, C, Green, E, Perol, M, Besse, B, Blay, J-Y, Saintigny, P, Planchard, D

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1556P - Circulating tumour DNA (ctDNA) analysis depicts mechanisms of resistance and tumour response to BRAF inhibitors in BRAF-mutant non-small cell lung cancer (NSCLC) von Ortiz - Cuaran, S., Mezquita, L., Swalduz, A., Aldea, M., Mazieres, J., Jovelet, C., Lacroix, L., Pradines, A., Avrillon, V., MahierAït Oukhatar, C., Hoog-Labouret, N., Howarth, K., Guichou, J.-F., Morris, C., Green, E., Perol, M., Besse, B., Blay, J.-Y., Saintigny, P., Planchard, D.

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Circulating tumour DNA (ctDNA) analysis depicts mechanisms of resistance and tumour response to BRAF inhibitors in BRAF-mutant non-small cell lung cancer (NSCLC) von Ortiz - Cuaran, S., Mezquita, L., Swalduz, A., Aldea, M., Mazieres, J., Jovelet, C., Lacroix, L., Pradines, A., Avrillon, V., MahierAït Oukhatar, C., Hoog-Labouret, N., Howarth, K., Guichou, J.-F., Morris, C., Green, E., Perol, M., Besse, B., Blay, J.-Y., Saintigny, P., Planchard, D.

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Polymerization-induced enhancement of binding and binding-induced polymerization von Ortiz, J., Guichou, J.F., Chavanieu, A., Sánchez, F., Prado-Gotor, R.

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Structural Basis for the Interaction between Focal Adhesion Kinase and CD4 von Garron, Marie-Line, Arthos, James, Guichou, Jean-François, McNally, Jonathan, Cicala, Claudia, Arold, Stefan T.

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Characterization of the Interaction between Retinoic Acid Receptor/Retinoid X Receptor (RAR/RXR) Heterodimers and Transcriptional Coactivators through Structural and Fluorescence A... von Pogenberg, Vivian, Guichou, Jean-François, Vivat-Hannah, Valérie, Kammerer, Sabrina, Pérez, Efrén, Germain, Pierre, de Lera, Angel R., Gronemeyer, Hinrich, Royer, Catherine A., Bourguet, William

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Structure-Based Design, Synthesis, and Biological Evaluation of Novel Inhibitors of Human Cyclophilin A von Guichou, Jean-François, Viaud, Julien, Mettling, Clément, Subra, Guy, Lin, Yea-Lih, Chavanieu, Alain

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Crystal Structure of the Coiled-coil Dimerization Motif of Geminin: Structural and Functional Insights on DNA Replication Regulation von Thépaut, Michel, Maiorano, Domenico, Guichou, Jean-François, Augé, Marie-Thérèse, Dumas, Christian, Méchali, Marcel, Padilla, André

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Pseudo-prolines (ΨPro): direct insertion of ΨPro systems into cysteine containing peptides von Guichou, Jean-François, Patiny, Luc, Mutter, Manfred

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Purification and crystallization of the heterodimeric complex of RARβ and RXRα ligand-binding domains in the active conformation von Pogenberg, Vivian, Guichou, Jean-François, Bourguet, William

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Crosslinking Photosensitized by a Ruthenium Chelate as a Tool for Labeling and Topographical Studies of G-Protein-Coupled Receptors von Duroux-Richard, Isabelle, Vassault, Philippe, Subra, Guy, Guichou, Jean-François, Richard, Eric, Mouillac, Bernard, Barberis, Claude, Marie, Jacky, Bonnafous, Jean-Claude

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Synthesis and characterization of constrained cyclosporin A derivatives containing a pseudo-proline group von Patiny, Luc, Guichou, Jean-François, Keller, Michael, Turpin, Olivier, Rückle, Thomas, Lhote, Philippe, Buetler, Timo M., Ruegg, Urs T., Wenger, Roland M., Mutter, Manfred

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Characterization of Aspartic Acid and β-Aspartic Acid in Peptides by Fast-atom Bombardment Mass Spectrometry and Tandem Mass Spectrometry von Castet, S., Enjalbal, C., Fulcrand, P., Guichou, J. F., Martinez, J., Aubagnac, J. -L.

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MA21.07 Circulating Tumor DNA Analysis Depicts Potential Mechanisms of Resistance to BRAF-Targeted Therapies in BRAF+ Non-Small Cell Lung Cancer von Ortiz-Cuaran, S., Mezquita, L., Swalduz, A., Aldea, M., Mazieres, J., Jovelet, C., Flores, W.R. Chumbi, Lacroix, L., Loriot, Y., Friboulet, L., Westeel, V., Ngocamus, M., Pradines, A., Tissot, C., Duchene, C. Clement, Raynaud, C., Quantin, X., Gervais, R., Brain, E., Monnet, I., Leprieur, E. Giroux, Avrillon, V., Mahier-Aït Oukhatar, C., Hoog-Labouret, N., De Kievit, F., Howarth, K., Guichou, J., Morris, C., Green, E., Perol, M., Besse, B., Blay, J., Saintigny, P., Planchard, D.

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