Discovery of 4‑{4-[(3R)‑3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}‑1H‑indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monot... von Foote, Kevin M, Blades, Kevin, Cronin, Anna, Fillery, Shaun, Guichard, Sylvie S, Hassall, Lorraine, Hickson, Ian, Jacq, Xavier, Jewsbury, Philip J, McGuire, Thomas M, Nissink, J. Willem M, Odedra, Rajesh, Page, Ken, Perkins, Paula, Suleman, Abid, Tam, Kin, Thommes, Pia, Broadhurst, Rebecca, Wood, Christine

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Discovery of 4-{4-[(3 R )-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1 H -indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with M... von Foote, Kevin M., Blades, Kevin, Cronin, Anna, Fillery, Shaun, Guichard, Sylvie S., Hassall, Lorraine, Hickson, Ian, Jacq, Xavier, Jewsbury, Philip J., McGuire, Thomas M., Nissink, J. Willem M., Odedra, Rajesh, Page, Ken, Perkins, Paula, Suleman, Abid, Tam, Kin, Thommes, Pia, Broadhurst, Rebecca, Wood, Christine

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Pour une géographie sociale des espaces et des pratiques funéraires von Calenda

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Productions alimentaires et catastrophes au Japon von Calenda

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AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules von Guichard, Sylvie M, Curwen, Jon, Bihani, Teeru, D'Cruz, Celina M, Yates, James W T, Grondine, Michael, Howard, Zoe, Davies, Barry R, Bigley, Graham, Klinowska, Teresa, Pike, Kurt G, Pass, Martin, Chresta, Christine M, Polanska, Urszula M, McEwen, Robert, Delpuech, Oona, Green, Stephen, Cosulich, Sabina C

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Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors von Sommer, Eeva M, Dry, Hannah, Cross, Darren, Guichard, Sylvie, Davies, Barry R, Alessi, Dario R

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Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro von Jordan, Nicola J, Dutkowski, Carol M, Barrow, Denise, Mottram, Huw J, Hutcheson, Iain R, Nicholson, Robert I, Guichard, Sylvie M, Gee, Julia M W

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Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation von Cope, Claire L, Gilley, Rebecca, Balmanno, Kathryn, Sale, Matthew J, Howarth, Karen D, Hampson, Mark, Smith, Paul D, Guichard, Sylvie M, Cook, Simon J

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Olutasidenib (FT-2102) in patients with relapsed or refractory IDH1-mutant glioma: A multicenter, open-label, phase Ib/II trial von de la Fuente, Macarena I, Colman, Howard, Rosenthal, Mark, Van Tine, Brian A, Levacic, Danijela, Walbert, Tobias, Gan, Hui K, Vieito, Maria, Milhem, Mohammed M, Lipford, Kathryn, Forsyth, Sanjeev, Guichard, Sylvie M, Mikhailov, Yelena, Sedkov, Alexander, Brevard, Julie, Kelly, Patrick F, Mohamed, Hesham, Monga, Varun

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mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling von Rodrik-Outmezguine, Vanessa S, Chandarlapaty, Sarat, Pagano, Nen C, Poulikakos, Poulikos I, Scaltriti, Maurizio, Moskatel, Elizabeth, Baselga, José, Guichard, Sylvie, Rosen, Neal

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A comprehensive map of preferentially located motifs reveals distinct proximal cis-regulatory sequences in plants von Rozière, Julien, Guichard, Cécile, Brunaud, Véronique, Martin, Marie-Laure, Coursol, Sylvie

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AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells Reducing B-Cell Receptor-Mediated Survival von Cosimo, Emilio, Tarafdar, Anuradha, Moles, Michael W, Holroyd, Ailsa K, Malik, Natasha, Catherwood, Mark A, Hay, Jodie, Dunn, Karen M, Macdonald, Alan M, Guichard, Sylvie M, O'Rourke, Declan, Leach, Michael T, Sansom, Owen J, Cosulich, Sabina C, McCaig, Alison M, Michie, Alison M

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Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs von Lopez, Jonathan, Mommert, Marine, Mouton, William, Pizzorno, Andrés, Brengel-Pesce, Karen, Mezidi, Mehdi, Villard, Marine, Lina, Bruno, Richard, Jean-Christophe, Fassier, Jean-Baptiste, Cheynet, Valérie, Padey, Blandine, Duliere, Victoria, Julien, Thomas, Paul, Stéphane, Bastard, Paul, Belot, Alexandre, Bal, Antonin, Casanova, Jean-Laurent, Rosa-Calatrava, Manuel, Morfin, Florence, Walzer, Thierry, Trouillet-Assant, Sophie

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Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055) von HOLT, Sarah V, LOGIE, Armelle, WILKINSON, Robert W, GUICHARD, Sylvie M, SMITH, Paul D, DAVIES, Barry R, ALFEREZ, Denis, RUNSWICK, Sarah, FENTON, Sarah, CHRESTA, Christine M, YI GU, JINGCHUAN ZHANG, WU, Yi-Long

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FT-4202, a selective pyruvate kinase R activator for sickle cell disease von Ericsson, Anna, Richard, David J., Wilker, Erik, Lancia, David R., Fessler, Shawn, Troccolo, Paul, Zheng, Xiaozhang, Toms, Angela, Dinsmore, Christopher, Yao, Lili, Kuypers, Frans A., Larkin, Sandra, Marcotte, Douglas, Fulzele, Keertik, Ribadeneira, Maria, Guichard, Sylvie M., Marshall, Gary

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Olutasidenib alone or with azacitidine in IDH1-mutated acute myeloid leukaemia and myelodysplastic syndrome: phase 1 results of a phase 1/2 trial von Watts, Justin M, Baer, Maria R, Yang, Jay, Prebet, Thomas, Lee, Sangmin, Schiller, Gary J, Dinner, Shira N, Pigneux, Arnaud, Montesinos, Pau, Wang, Eunice S, Seiter, Karen P, Wei, Andrew H, De Botton, Stephane, Arnan, Montserrat, Donnellan, Will, Schwarer, Anthony P, Récher, Christian, Jonas, Brian A, Ferrell, P Brent, Marzac, Christophe, Kelly, Patrick, Sweeney, Jennifer, Forsyth, Sanjeev, Guichard, Sylvie M, Brevard, Julie, Henrick, Patrick, Mohamed, Hesham, Cortes, Jorge E

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Rainfall regime across the Sahel band in the Gourma region, Mali von Frappart, Frédéric, Hiernaux, Pierre, Guichard, Françoise, Mougin, Eric, Kergoat, Laurent, Arjounin, Marc, Lavenu, François, Koité, Mohamed, Paturel, Jean-Emmanuel, Lebel, Thierry

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Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells von Sini, Patrizia, James, Dominic, Chresta, Christine, Guichard, Sylvie

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Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent von Foote, Kevin M, Nissink, J. Willem M, McGuire, Thomas, Turner, Paul, Guichard, Sylvie, Yates, James W. T, Lau, Alan, Blades, Kevin, Heathcote, Dan, Odedra, Rajesh, Wilkinson, Gary, Wilson, Zena, Wood, Christine M, Jewsbury, Philip J

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The Indian nation and selective amnesia: representing conflicts and violence in Indian history textbooks von Guichard, Sylvie

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