Clinical Parameters and Metabolomic Biomarkers That Predict Inhospital Outcomes in Patients With ST-Segment Elevated Myocardial Infarctions von Liu, Jie, Huang, Lei, Shi, Xinrong, Gu, Chungang, Xu, Hongmin, Liu, Shuye

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The impact of radiochemistry in drug projects: The use of C‐14 label in the AZD8529, AZD7325, and AZD6280 projects von Kingston, Lee, Gu, Chungang, Guo, Jian, Swallow, Steve, Elmore, Charles S.

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Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology von Johannes, Jeffrey W, Almeida, Lynsie, Barlaam, Bernard, Boriack-Sjodin, P. Ann, Casella, Robert, Croft, Rosemary A, Dishington, Allan P, Gingipalli, Lakshmaiah, Gu, Chungang, Hawkins, Janet L, Holmes, Jane L, Howard, Tina, Huang, Jian, Ioannidis, Stephanos, Kazmirski, Steven, Lamb, Michelle L, McGuire, Thomas M, Moore, Jane E, Ogg, Derek, Patel, Anil, Pike, Kurt G, Pontz, Timothy, Robb, Graeme R, Su, Nancy, Wang, Haiyun, Wu, Xiaoyun, Zhang, Hai-Jun, Zhang, Yue, Zheng, Xiaolan, Wang, Tao

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Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering von Gu, Chungang, Lamb, Michelle L., Johannes, Jeffrey W., Sylvester, Mark A., Eisman, Mark S., Harrison, Rane A., Hu, Haiqing, Kazmirski, Steven, Mikule, Keith, Peng, Bo, Su, Nancy, Wang, Wenxian, Ye, Qing, Zheng, Xiaolan, Lyne, Paul D., Scott, David A.

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P186 - pH dependent CES1 mediated hydrolysis of vixotrigine in human liver microsomes von Johnson, Joshua, Rooney, Michael, Gu, Chungang

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Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct von Gu, Chungang, Elmore, Charles S, Lin, Jianrong, Zhou, Diansong, Luzietti, Rick, Dorff, Peter, Grimm, Scott W

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In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor von JIAN GUO, CHUNGANG GU, DIANSONG ZHOU, ELMORE, Charles S, BUI, Khanh H, GRIMM, Scott W

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Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors von Powell, Noel A., Ciske, Fred L., Cai, Cuiman, Holsworth, Daniel D., Mennen, Ken, Van Huis, Chad A., Jalaie, Mehran, Day, Jacqueline, Mastronardi, Michelle, McConnell, Pat, Mochalkin, Igor, Zhang, Erli, Ryan, Michael J., Bryant, John, Collard, Wendy, Ferreira, Suzie, Gu, Chungang, Collins, Roxane, Edmunds, Jeremy J.

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Use of High-Performance Liquid Chromatography−Tandem Mass Spectrometry To Distinguish Panax ginseng C. A. Meyer (Asian Ginseng) and Panax quinquefolius L. (North American Ginseng)... von Li, Wenkui, Gu, Chungang, Zhang, Hongjie, Awang, Dennis V. C, Fitzloff, John F, Fong, Harry H. S, van Breemen, Richard B

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Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors von Sun, Yongkai, Gu, Chungang, Liu, Xuemei, Liang, Wenzhong, Yao, Ping, Bolton, Judy L., van Breemen, Richard B.

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Quantitative Analysis of Lycopene Isomers in Human Plasma Using High-Performance Liquid Chromatography−Tandem Mass Spectrometry von Fang, Liqiong, Pajkovic, Natasa, Wang, Yan, Gu, Chungang, van Breemen, Richard B.

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BTK-inhibitor drug covalent binding to lysine in human serum albumin using LC-MS/MS von Muste, Cathy, Gu, Chungang

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Late-occurring and long-circulating metabolites of GABA A receptor modulator AZD7325 involving metabolic cyclization and aromatization: Relevance to mist analysis and application f... von Gu, Chungang (Chuck), Artelsmair, Markus, Elmore, Charles S., Davis, Patty, Hall, James E., Lewis, Richard J., Dembofsky, Bruce, Christoph, Greg, Ramaker, Michael, Smith, Mark A., Chapdelaine, Marc, Sunzel, Maria

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Selective Gas-Phase Cleavage at the Peptide Bond C-Terminal to Aspartic Acid in Fixed-Charge Derivatives of Asp-Containing Peptides von Gu, Chungang, Tsaprailis, George, Breci, Linda, Wysocki, Vicki H

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Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms von Liu, Jianghua, Burdette, Joanna E, Xu, Haiyan, Gu, Chungang, van Breemen, Richard B, Bhat, Krishna P. L, Booth, Nancy, Constantinou, Andreas I, Pezzuto, John M, Fong, Harry H. S, Farnsworth, Norman R, Bolton, Judy L

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Preclinical safety, toxicokinetics and metabolism of BIIB131, a novel prothrombolytic agent for acute stroke von Kostrubsky, Vick, Liu, Ying, Muste, Cathy, Gu, Chungang, Kirkland, Melissa, Nishimura, Naoko, Hasegawa, Keiko, Hasumi, Keiji, Yuan, Long

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Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies von Barlaam, Bernard, Casella, Robert, Cidado, Justin, Cook, Calum, De Savi, Chris, Dishington, Allan, Donald, Craig S, Drew, Lisa, Ferguson, Andrew D, Ferguson, Douglas, Glossop, Steve, Grebe, Tyler, Gu, Chungang, Hande, Sudhir, Hawkins, Janet, Hird, Alexander W, Holmes, Jane, Horstick, James, Jiang, Yun, Lamb, Michelle L, McGuire, Thomas M, Moore, Jane E, O’Connell, Nichole, Pike, Andy, Pike, Kurt G, Proia, Theresa, Roberts, Bryan, San Martin, Maryann, Sarkar, Ujjal, Shao, Wenlin, Stead, Darren, Sumner, Neil, Thakur, Kumar, Vasbinder, Melissa M, Varnes, Jeffrey G, Wang, Jianyan, Wang, Lei, Wu, Dedong, Wu, Liangwei, Yang, Bin, Yao, Tieguang

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The Importance of Tracking “Missing” Metabolites: How and Why? von Wang, Shuai, Ballard, T. Eric, Christopher, Lisa J., Foti, Robert S., Gu, Chungang, Khojasteh, S. Cyrus, Liu, Joyce, Ma, Shuguang, Ma, Bin, Obach, R. Scott, Schadt, Simone, Zhang, Zhoupeng, Zhang, Donglu

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Design and Synthesis of Acyclic Boronic Acid Arginase Inhibitors von Shields, Jason D., Aquila, Brian M., Emmons, David, Finlay, M. Raymond V., Gangl, Eric T., Gu, Chungang, Mlynarski, Scott N., Petersen, Jens, Pop-Damkov, Petar, Sha, Li, Simpson, Iain, Tavakoli, Siavash, Tentarelli, Sharon, Wang, Haixia, Ye, Qing, Zheng, XiaoLan

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CYP-Mediated Sulfoximine Deimination of AZD6738 von Jones, Barry C, Markandu, Roshini, Gu, Chungang, Scarfe, Graeme

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