‘Off-the-shelf’ allogeneic CAR T cells: development and challenges von Depil, S., Duchateau, P., Grupp, S. A., Mufti, G., Poirot, L.

Volltext

Current concepts in the diagnosis and management of cytokine release syndrome von Lee, Daniel W., Gardner, Rebecca, Porter, David L., Louis, Chrystal U., Ahmed, Nabil, Jensen, Michael, Grupp, Stephan A., Mackall, Crystal L.

Volltext

Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel von Porter, David, Frey, Noelle, Wood, Patricia A, Weng, Yanqiu, Grupp, Stephan A

Volltext

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia von Maude, Shannon L, Laetsch, Theodore W, Buechner, Jochen, Rives, Susana, Boyer, Michael, Bittencourt, Henrique, Bader, Peter, Verneris, Michael R, Stefanski, Heather E, Myers, Gary D, Qayed, Muna, De Moerloose, Barbara, Hiramatsu, Hidefumi, Schlis, Krysta, Davis, Kara L, Martin, Paul L, Nemecek, Eneida R, Yanik, Gregory A, Peters, Christina, Baruchel, Andre, Boissel, Nicolas, Mechinaud, Francoise, Balduzzi, Adriana, Krueger, Joerg, June, Carl H, Levine, Bruce L, Wood, Patricia, Taran, Tetiana, Leung, Mimi, Mueller, Karen T, Zhang, Yiyun, Sen, Kapildeb, Lebwohl, David, Pulsipher, Michael A, Grupp, Stephan A

Volltext

Chimeric Antigen Receptor Therapy for Cancer von Barrett, David M, Singh, Nathan, Porter, David L, Grupp, Stephan A, June, Carl H

Volltext

Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia von Orlando, Elena J., Han, Xia, Tribouley, Catherine, Wood, Patricia A., Leary, Rebecca J., Riester, Markus, Levine, John E., Qayed, Muna, Grupp, Stephan A., Boyer, Michael, De Moerloose, Barbara, Nemecek, Eneida R., Bittencourt, Henrique, Hiramatsu, Hidefumi, Buechner, Jochen, Davies, Stella M., Verneris, Michael R., Nguyen, Kevin, Brogdon, Jennifer L., Bitter, Hans, Morrissey, Michael, Pierog, Piotr, Pantano, Serafino, Engelman, Jeffrey A., Winckler, Wendy

Volltext

Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia von Mueller, Karen Thudium, Maude, Shannon L., Porter, David L., Frey, Noelle, Wood, Patricia, Han, Xia, Waldron, Edward, Chakraborty, Abhijit, Awasthi, Rakesh, Levine, Bruce L., Melenhorst, J. Joseph, Grupp, Stephan A., June, Carl H., Lacey, Simon F.

Volltext

Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies von Ruella, Marco, Barrett, David M, Kenderian, Saad S, Shestova, Olga, Hofmann, Ted J, Perazzelli, Jessica, Klichinsky, Michael, Aikawa, Vania, Nazimuddin, Farzana, Kozlowski, Miroslaw, Scholler, John, Lacey, Simon F, Melenhorst, Jan J, Morrissette, Jennifer J D, Christian, David A, Hunter, Christopher A, Kalos, Michael, Porter, David L, June, Carl H, Grupp, Stephan A, Gill, Saar

Volltext

Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial von Bride, Karen L., Vincent, Tiffaney, Smith-Whitley, Kim, Lambert, Michele P., Bleesing, Jack J., Seif, Alix E., Manno, Catherine S., Casper, James, Grupp, Stephan A., Teachey, David T.

Volltext

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy von Sotillo, Elena, Barrett, David M, Black, Kathryn L, Bagashev, Asen, Oldridge, Derek, Wu, Glendon, Sussman, Robyn, Lanauze, Claudia, Ruella, Marco, Gazzara, Matthew R, Martinez, Nicole M, Harrington, Colleen T, Chung, Elaine Y, Perazzelli, Jessica, Hofmann, Ted J, Maude, Shannon L, Raman, Pichai, Barrera, Alejandro, Gill, Saar, Lacey, Simon F, Melenhorst, Jan J, Allman, David, Jacoby, Elad, Fry, Terry, Mackall, Crystal, Barash, Yoseph, Lynch, Kristen W, Maris, John M, Grupp, Stephan A, Thomas-Tikhonenko, Andrei

Volltext

IgH-V(D)J NGS-MRD measurement pre- and early post-allotransplant defines very low- and very high-risk ALL patients von Pulsipher, Michael A., Carlson, Chris, Langholz, Bryan, Wall, Donna A., Schultz, Kirk R., Bunin, Nancy, Kirsch, Ilan, Gastier-Foster, Julie M., Borowitz, Michael, Desmarais, Cindy, Williamson, David, Kalos, Michael, Grupp, Stephan A.

Volltext

Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure von Richardson, Paul G., Riches, Marcie L., Kernan, Nancy A., Brochstein, Joel A., Mineishi, Shin, Termuhlen, Amanda M., Arai, Sally, Grupp, Stephan A., Guinan, Eva C., Martin, Paul L., Steinbach, Gideon, Krishnan, Amrita, Nemecek, Eneida R., Giralt, Sergio, Rodriguez, Tulio, Duerst, Reggie, Doyle, John, Antin, Joseph H., Smith, Angela, Lehmann, Leslie, Champlin, Richard, Gillio, Alfred, Bajwa, Rajinder, D’Agostino Sr, Ralph B., Massaro, Joseph, Warren, Diane, Miloslavsky, Maja, Hume, Robin L., Iacobelli, Massimo, Nejadnik, Bijan, Hannah, Alison L., Soiffer, Robert J.

Volltext

Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia von Tasian, Sarah K., Teachey, David T., Li, Yong, Shen, Feng, Harvey, Richard C., Chen, I-Ming, Ryan, Theresa, Vincent, Tiffaney L., Willman, Cheryl L., Perl, Alexander E., Hunger, Stephen P., Loh, Mignon L., Carroll, Martin, Grupp, Stephan A.

Volltext

Exagamglogene Autotemcel for Severe Sickle Cell Disease von Frangoul, Haydar, Locatelli, Franco, Sharma, Akshay, Bhatia, Monica, Mapara, Markus, Molinari, Lyndsay, Wall, Donna, Liem, Robert I., Telfer, Paul, Shah, Ami J., Cavazzana, Marina, Corbacioglu, Selim, Rondelli, Damiano, Meisel, Roland, Dedeken, Laurence, Lobitz, Stephan, de Montalembert, Mariane, Steinberg, Martin H., Walters, Mark C., Eckrich, Michael J., Imren, Suzan, Bower, Laura, Simard, Christopher, Zhou, Weiyu, Xuan, Fengjuan, Morrow, Phuong Khanh, Hobbs, William E., Grupp, Stephan A.

Volltext

Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance von Boyiadzis, Michael M, Dhodapkar, Madhav V, Brentjens, Renier J, Kochenderfer, James N, Neelapu, Sattva S, Maus, Marcela V, Porter, David L, Maloney, David G, Grupp, Stephan A, Mackall, Crystal L, June, Carl H, Bishop, Michael R

Volltext

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events von Maus, Marcela V, Alexander, Sara, Bishop, Michael R, Brudno, Jennifer N, Callahan, Colleen, Davila, Marco L, Diamonte, Claudia, Dietrich, Jorg, Fitzgerald, Julie C, Frigault, Matthew J, Fry, Terry J, Holter-Chakrabarty, Jennifer L, Komanduri, Krishna V, Lee, Daniel W, Locke, Frederick L, Maude, Shannon L, McCarthy, Philip L, Mead, Elena, Neelapu, Sattva S, Neilan, Tomas G, Santomasso, Bianca D, Shpall, Elizabeth J, Teachey, David T, Turtle, Cameron J, Whitehead, Tom, Grupp, Stephan A

Volltext

The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer von Lee, Daniel W, Barrett, David M, Mackall, Crystal, Orentas, Rimas, Grupp, Stephan A

Volltext

Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia von Maude, Shannon L., Tasian, Sarah K., Vincent, Tiffaney, Hall, Junior W., Sheen, Cecilia, Roberts, Kathryn G., Seif, Alix E., Barrett, David M., Chen, I-Ming, Collins, J. Racquel, Mullighan, Charles G., Hunger, Stephen P., Harvey, Richard C., Willman, Cheryl L., Fridman, Jordan S., Loh, Mignon L., Grupp, Stephan A., Teachey, David T.

Volltext

Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial von Kreissman, Susan G, Prof Dr, Seeger, Robert C, Prof, Matthay, Katherine K, Prof, London, Wendy B, PhD, Sposto, Richard, Prof, Grupp, Stephan A, Prof, Haas-Kogan, Daphne A, Prof, LaQuaglia, Michael P, Prof, Yu, Alice L, Prof, Diller, Lisa, Prof, Buxton, Allen, MS, Park, Julie R, Prof, Cohn, Susan L, Prof, Maris, John M, Prof, Reynolds, C Patrick, Prof, Villablanca, Judith G, Prof

Volltext

CAR-T cells: Early successes in blood cancer and challenges in solid tumors von Dana, Hassan, Chalbatani, Ghanbar Mahmoodi, Jalali, Seyed Amir, Mirzaei, Hamid Reza, Grupp, Stephan A., Suarez, Eloah Rabello, Rapôso, Catarina, Webster, Thomas J.

Volltext