PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of... von Grouix, Brigitte, Sarra-Bournet, Francois, Leduc, Martin, Simard, Jean-Christophe, Hince, Kathy, Geerts, Lilianne, Blais, Alexandra, Gervais, Liette, Laverdure, Alexandre, Felton, Alexandra, Richard, Jonathan, Ouboudinar, Jugurtha, Gagnon, William, Leblond, François A, Laurin, Pierre, Gagnon, Lyne

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Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease von Simard, Jean-Christophe, Thibodeau, Jean-François, Leduc, Martin, Tremblay, Mikael, Laverdure, Alexandre, Sarra-Bournet, François, Gagnon, William, Ouboudinar, Jugurtha, Gervais, Liette, Felton, Alexandra, Letourneau, Sylvie, Geerts, Lilianne, Cloutier, Marie-Pier, Hince, Kathy, Corpuz, Ramon, Blais, Alexandra, Quintela, Vanessa Marques, Duceppe, Jean-Simon, Abbott, Shaun D., Blais, Amélie, Zacharie, Boulos, Laurin, Pierre, Laplante, Steven R., Kennedy, Christopher R. J., Hébert, Richard L., Leblond, François A., Grouix, Brigitte, Gagnon, Lyne

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PBI-4050 via GPR40 activation improves adenine-induced kidney injury in mice von Thibodeau, Jean-François, Simard, Jean-Christophe, Holterman, Chet E, Blais, Amélie, Cloutier, Marie-Pier, Medeiros, Thalia, Leduc, Martin, Grouix, Brigitte, Leblond, François A, Burger, Dylan, Hébert, Richard L, Kennedy, Christopher R J, Gagnon, Lyne

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Design and Synthesis of New 1,3,5-Trisubstituted Triazines for the Treatment of Cancer and Inflammation von Zacharie, Boulos, Abbott, Shaun D, Duceppe, Jean-Simon, Gagnon, Lyne, Grouix, Brigitte, Geerts, Lilianne, Gervais, Liette, Sarra-Bournet, François, Perron, Valérie, Wilb, Nicole, Penney, Christopher L, Laurin, Pierre

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FRI217 - PBI-4050 promotes hepatic stellate cell deactivation by shifting energy metabolism von Grouix, Brigitte, Sarra-Bournet, François, Simard, Jean-Christophe, Thibodeau, Jean-Francois, Leduc, Martin, Gagnon, Lyne

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PBI-4050 promotes hepatic stellate cell deactivation by shifting energy metabolism von Grouix, Brigitte, Sarra-Bournet, François, Simard, Jean-Christophe, Thibodeau, Jean-Francois, Leduc, Martin, Gagnon, Lyne

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A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84 von Gagnon, Lyne, Leduc, Martin, Thibodeau, Jean-Francois, Zhang, Ming-Zhi, Grouix, Brigitte, Sarra-Bournet, Francois, Gagnon, William, Hince, Kathy, Tremblay, Mikaël, Geerts, Lilianne, Kennedy, Christopher R J, Hébert, Richard L, Gutsol, Alex, Holterman, Chet E, Kamto, Eldjonai, Gervais, Liette, Ouboudinar, Jugurtha, Richard, Jonathan, Felton, Alexandra, Laverdure, Alexandre, Simard, Jean-Christophe, Létourneau, Sylvie, Cloutier, Marie-Pier, Leblond, Francois A, Abbott, Shaun D, Penney, Christopher, Duceppe, Jean-Simon, Zacharie, Boulos, Dupuis, Jocelyn, Calderone, Angelino, Nguyen, Quang T, Harris, Raymond C, Laurin, Pierre

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PBI-4050 restores liver and adipose tissue metabolic homeostasis, and decreases fibrosis in a high-fat-diet mouse model of non-alcoholic fatty liver disease von Grouix, Brigitte, Simard, Jean-Christophe, Thibodeau, Jean-Francois, Tremblay, Mikaël, Laverdure, Alexandre, Sarra-Bournet, François, Corpuz, Ramon, Gagnon, Lyne

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SAT008 - PBI-4050 restores liver and adipose tissue metabolic homeostasis, and decreases fibrosis in a high-fat-diet mouse model of non-alcoholic fatty liver disease von Grouix, Brigitte, Simard, Jean-Christophe, Thibodeau, Jean-Francois, Tremblay, Mikaël, Laverdure, Alexandre, Sarra-Bournet, François, Corpuz, Ramon, Gagnon, Lyne

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FO008FATTY ACID RECEPTORS GPR40/GPR84: TWO PROMISING TARGETS IN KIDNEY FIBROSIS von Gagnon, Lyne, Leduc, Martin, Thibodeau, Jean-Francois, Leblond, François A, Laurin, Pierre, Grouix, Brigitte

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SP345ACTIVATION OF THE FREE-FATTY ACID RECEPTOR GPR40 IMPROVES ANEMIA IN MOUSE MODELS OF KIDNEY DISEASE VIA A NOVEL EPO-INDEPENDENT MECHANISM OF ACTION von Gagnon, Lyne, Thibodeau, Jean-Francois, Holterman, Chet, Laurin, Pierre, Hébert, Richard, Kennedy, Christopher, Grouix, Brigitte

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PBI-4050 reduces pulmonary hypertension, lung fibrosis, and right ventricular dysfunction in heart failure von Nguyen, Quang T, Nsaibia, Mohamed J, Sirois, Martin G, Calderone, Angelino, Tardif, Jean-Claude, Fen Shi, Yan, Ruiz, Matthieu, Daneault, Caroline, Gagnon, Lyne, Grouix, Brigitte, Laurin, Pierre, Dupuis, Jocelyn

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SP436PBI-4050 IMPROVES METABOLIC REGULATION AND DIABETIC NEPHROPATHY THROUGH REDUCTION OF ER STRESS, PRO-INFLAMMATORY/FIBROTIC MARKERS, GALECTIN-3 EXPRESSION AND INFLAMMATORY CELL... von Gagnon, Lyne, Simard, Jean-Christophe, Cloutier, Marie-Pier, Laverdure, Alexandre, Richard, Jonathan, Gervais, Liette, Felton, Alexandra, Laurin, Pierre, Grouix, Brigitte

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281-LB: PBI-4547 Orchestrates a Cross Talk between Liver and White Adipose Tissues to Correct Metabolic Reprogramming von SIMARD, JEAN-CHRISTOPHE, THIBODEAU, JEAN-FRANCOIS, LEDUC, MARTIN, TREMBLAY, MIKAËL, LAVERDURE, ALEXANDRE, CORPUZ, RAMON, LEBLOND, FRANÇOIS A., GROUIX, BRIGITTE, GAGNON, LYNE

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FRI-097-PBI-4050 treatment decreases sepsis-induced liver injury in mice von Thibodeau, Jean-François, Grouix, Brigitte, Simard, Jean-Christophe, Holterman, Chet, Gutsol, Alex, Blais, Alexandra, Laverdure, Alexandre, Hébert, Richard, Leblond, François, Laurin, Pierre, Kennedy, Chris, Gagnon, Lyne

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THU-078-PBI-4050 inhibits hepatic stellate cell activation, restores autophagy, and reduces CCl4-induced liver fibrosis von Grouix, Brigitte, Sarra-Bournet, François, Geerts, Lilianne, Hince, Kathy, Tremblay, Mikaël, Felton, Alexandra, Blais, Alexandra, Ouboudinar, Jugurtha, Simard, Jean-Christophe, Laurin, Pierre, Gagnon, Lyne

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PS-134-Oral treatment with PBI-4547 promotes beta-oxidation and energy expenditure, and reverses liver damage and white adipose tissue fibrosis in high-fat diet and ob/ob mouse mod... von Grouix, Brigitte, Laverdure, Alexandre, Sarra-Bournet, François, Tremblay, Mikaël, Cloutier, Marie-Pier, Gervais, Liette, Richard, Jonathan, Felton, Alexandra, Laurin, Pierre, Gagnon, Lyne

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PBI-4050 reduces pulmonary hypertension, lung fibrosis, and right ventricular dysfunction in heart failure von Nguyen, Quang T., Nsaibia, Mohamed J., Sirois, Martin G., Calderone, Angelino, Tardif, Jean-Claude, Fen Shi, Yan, Ruiz, Matthieu, Daneault, Caroline, Gagnon, Lyne, Grouix, Brigitte, Laurin, Pierre, Dupuis, Jocelyn

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PBI-4050 Improves Metabolic Regulation and Diabetic Nephropathy through Reduction of ER Stress, Pro-Inflammatory/Fibrotic Markers, Galectin-3 Expression, and Inflammatory Cell Infi... von SIMARD, JEAN-CHRISTOPHE, CLOUTIER, MARIE-PIER, LAVERDURE, ALEXANDRE, RICHARD, JONATHAN, GERVAIS, LIETTE, FELTON, ALEXANDRA, GROUIX, BRIGITTE, LAURIN, PIERRE, LEDUC, MARTIN, LEBLOND, FRANÇOIS A., GAGNON, LYNE

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PBI-4547 Prevents Progression of Prediabetic Condition to Type 1 Diabetes in NOD Mice von LEBLOND, FRANÇOIS A., HINCE, KATHY, SARRA-BOURNET, FRANÇOIS, GAGNON, WILLIAM, TREMBLAY, MIKAËL, CLOUTIER, MARIE-PIER, LÉTOURNEAU, SYLVIE, SIMARD, JEAN-CHRISTOPHE, LEDUC, MARTIN, GROUIX, BRIGITTE, LAURIN, PIERRE, GAGNON, LYNE

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