Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1 von Schoepfer, Joseph, Jahnke, Wolfgang, Berellini, Giuliano, Buonamici, Silvia, Cotesta, Simona, Cowan-Jacob, Sandra W, Dodd, Stephanie, Drueckes, Peter, Fabbro, Doriano, Gabriel, Tobias, Groell, Jean-Marc, Grotzfeld, Robert M, Hassan, A. Quamrul, Henry, Chrystèle, Iyer, Varsha, Jones, Darryl, Lombardo, Franco, Loo, Alice, Manley, Paul W, Pellé, Xavier, Rummel, Gabriele, Salem, Bahaa, Warmuth, Markus, Wylie, Andrew A, Zoller, Thomas, Marzinzik, Andreas L, Furet, Pascal

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A small molecule–kinase interaction map for clinical kinase inhibitors von Fabian, Miles A, Biggs, William H, Treiber, Daniel K, Atteridge, Corey E, Azimioara, Mihai D, Benedetti, Michael G, Carter, Todd A, Ciceri, Pietro, Edeen, Philip T, Floyd, Mark, Ford, Julia M, Galvin, Margaret, Gerlach, Jay L, Grotzfeld, Robert M, Herrgard, Sanna, Insko, Darren E, Insko, Michael A, Lai, Andiliy G, Lélias, Jean-Michel, Mehta, Shamal A, Milanov, Zdravko V, Velasco, Anne Marie, Wodicka, Lisa M, Patel, Hitesh K, Zarrinkar, Patrick P, Lockhart, David J

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Binding or Bending: Distinction of Allosteric Abl Kinase Agonists from Antagonists by an NMR-Based Conformational Assay von Jahnke, Wolfgang, Grotzfeld, Robert M, Pellé, Xavier, Strauss, André, Fendrich, Gabriele, Cowan-Jacob, Sandra W, Cotesta, Simona, Fabbro, Doriano, Furet, Pascal, Mestan, Jürgen, Marzinzik, Andreas L

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Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Sele... von Chao, Qi, Sprankle, Kelly G, Grotzfeld, Robert M, Lai, Andiliy G, Carter, Todd A, Velasco, Anne Marie, Gunawardane, Ruwanthi N, Cramer, Merryl D, Gardner, Michael F, James, Joyce, Zarrinkar, Patrick P, Patel, Hitesh K, Bhagwat, Shripad S

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Inhibition of Drug-Resistant Mutants of ABL, KIT, and EGF Receptor Kinases von Carter, Todd A., Wodicka, Lisa M., Shah, Neil P., Velasco, Anne Marie, Fabian, Miles A., Treiber, Daniel K., Milanov, Zdravko V., Atteridge, Corey E., Biggs, William H., Edeen, Philip T., Floyd, Mark, Ford, Julia M., Grotzfeld, Robert M., Herrgard, Sanna, Insko, Darren E., Mehta, Shamal A., Patel, Hitesh K., Pao, William, Sawyers, Charles L., Varmus, Harold, Zarrinkar, Patrick P., Lockhart, David J.

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Discovery of Potent and Selective Antibody–Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization von Karpov, Alexei S, Nieto-Oberhuber, Cristina M, Abrams, Tinya, Beng-Louka, Edwige, Blanco, Enrique, Chamoin, Sylvie, Chene, Patrick, Dacquignies, Isabelle, Daniel, Dylan, Dillon, Michael P, Doumampouom-Metoul, Lionel, Drosos, Nikolaos, Fedoseev, Pavel, Furegati, Markus, Granda, Brian, Grotzfeld, Robert M, Hess Clark, Suzanna, Joly, Emilie, Jones, Darryl, Lacaud-Baumlin, Marion, Lagasse-Guerro, Stephanie, Lorenzana, Edward G, Mallet, William, Martyniuk, Piotr, Marzinzik, Andreas L, Mesrouze, Yannick, Nocito, Sandro, Oei, Yoko, Perruccio, Francesca, Piizzi, Grazia, Richard, Etienne, Rudewicz, Patrick J, Schindler, Patrick, Velay, Mélanie, Venstrom, Kristine, Wang, Peiyin, Zurini, Mauro, Lafrance, Marc

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Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors von Patel, Hitesh K., Grotzfeld, Robert M., Lai, Andiliy G., Mehta, Shamal A., Milanov, Zdravko V., Chao, Qi, Sprankle, Kelly G., Carter, Todd A., Velasco, Anne Marie, Fabian, Miles A., James, Joyce, Treiber, Daniel K., Lockhart, David J., Zarrinkar, Patrick P., Bhagwat, Shripad S.

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Control of Self-Assembly and Reversible Encapsulation of Xenon in a Self-Assembling Dimer by Acid-Base Chemistry von Branda, Neil, Grotzfeld, Robert M, Valdes, Carlos, Rebek, Julius Jr

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Reversible Encapsulation of Disc-Shaped Guests by a Synthetic, Self-Assembled Host von Grotzfeld, Robert M., Branda, Neil, Rebek, Julius

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Ring Inversion Dynamics of Encapsulated Cyclohexane von O'Leary, Brendan M, Grotzfeld, Robert M, Rebek, Julius

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Modular synthesis and modification of novel bifunctional dendrons von Tulli, Ludovico G, Miranda, Daniela, Lee, Cameron C, Sullivan, Yang, Grotzfeld, Robert, Hollingworth, Gregory, Kneuer, Rainer, Karpov, Alexei S

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Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display von Chin, Jason W, Grotzfeld, Robert M, Fabian, Miles A, Schepartz, Alanna

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Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site von Fabbro, Doriano, Manley, Paul W., Jahnke, Wolfgang, Liebetanz, Janis, Szyttenholm, Alexandra, Fendrich, Gabriele, Strauss, Andre, Zhang, Jianming, Gray, Nathanael S., Adrian, Francisco, Warmuth, Markus, Pelle, Xavier, Grotzfeld, Robert, Berst, Frederic, Marzinzik, Andreas, Cowan-Jacob, Sandra W., Furet, Pascal, Mestan, Jürgen

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ABL001, a Potent Allosteric Inhibitor of BCR-ABL, Prevents Emergence of Resistant Disease When Administered in Combination with Nilotinib in an in Vivo Murine Model of Chronic Myel... von Wylie, Andrew, Schoepfer, Joseph, Berellini, Giuliano, Cai, Hongbo, Caravatti, Giorgio, Cotesta, Simona, Dodd, Stephanie, Donovan, Jerry, Erb, Bernhard, Furet, Pascal, Gangal, Geeti, Grotzfeld, Robert, Hassan, Quamrul, Hood, Tami, Iyer, Varsha, Jacob, Sandra, Jahnke, Wolfgang, Lombardo, Franco, Loo, Alice, Manley, Paul W., Marzinzik, Andreas, Palmer, Michael, Pelle, Xavier, Salem, Bahaa, Sharma, Sreenath, Thohan, Sanjeev, Zhu, Suzanne, Keen, Nicholas, Petruzzelli, Lilli, Vanasse, K. Gary, Sellers, William R

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Derivados de benzamida para la inhibición de la actividad de ABL1, ABL2 y BCR-ABL1 von FURET, Pascal, GROTZFELD, Robert Martin, PELLE, Xavier Francois Andre, SALEM, Bahaa, JAHNKE, Wolfgang, DODD, Stephanie Kay, SCHOEPFER, Joseph, JONES, Darryl Brynley, MARZINZIK, Andreas, MANLEY, Paul

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Benzamidderivater til at hæmme aktiviteten af ABL1, ABL2 og BCR-ABL1 von FURET, Pascal, GROTZFELD, Robert Martin, PELLE, Xavier Francois Andre, SALEM, Bahaa, JAHNKE, Wolfgang, DODD, Stephanie Kay, SCHOEPFER, Joseph, JONES, Darryl Brynley, MARZINZIK, Andreas, MANLEY, Paul

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FATTY ACID-BIFUNCTIONAL DEGRADER CONJUGATES AND THEIR METHODS OF USE von Fazal, Tanzina, Hollingworth, Gregory John, Palermo, Mark Gabriel, Metcalf, III, Chester A, Zoller, Thomas, Duvadie, Rohit Kumar, Lorber, Julien, Plummer, Scott Vaughan, Li, Jialiang, Sendzik, Martin, Broennimann, Valerie, Vulpetti, Anna, Adcock, Claire, Grotzfeld, Robert Martin, Gao, Jinhai, Michael, Walter, Zhao, Liang, Usera, Aimee Richardson, Cheng, Jiashun, Guo, Fengfeng, Hebach, Christina, Zecri, Frederic, Karpov, Alexei, Jones, Darryl Brynley, Roache, James Harold, Thomas, Ranny Mathew

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FATTY ACID-BIFUNCTIONAL DEGRADER CONJUGATES AND THEIR METHODS OF USE von PLUMMER, Scott, Vaughan, SENDZIK, Martin, GROTZFELD, Robert, Martin, USERA, Aimee, Richardson, FAZAL, Tanzina, ADCOCK, Claire, METCALF III, Chester A, ZECRI, Frederic, ZOLLER, Thomas, THOMAS, Ranny, Mathew, GAO, Jinhai, MICHAEL, Walter, GUO, Fengfeng, DUVADIE, Rohit Kumar, KARPOV, Alexei, LORBER, Julien, ZHAO, Liang, HEBACH, Christina, PALERMO, Mark, Gabriel, JONES, Darryl, Brynley, LI, Jialiang, CHENG, Jiashun, VULPETTI, Anna, ROACHE, James, Harold, BROENNIMANN, Valerie, HOLLINGWORTH, Gregory John

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FATTY ACID-BIFUNCTIONAL DEGRADER CONJUGATES AND THEIR METHODS OF USE von SENDZIK, Martin, FAZAL, Tanzina, THOMAS, Ranny, ADCOCK, Claire, PLUMMER, Scott, METCALF III, Chester A, ROACHE, James, ZECRI, Frederic, ZOLLER, Thomas, GROTZFELD, Robert, GAO, Jinhai, MICHAEL, Walter, GUO, Fengfeng, DUVADIE, Rohit Kumar, KARPOV, Alexei, LORBER, Julien, ZHAO, Liang, HEBACH, Christina, LI, Jialiang, CHENG, Jiashun, VULPETTI, Anna, BROENNIMANN, Valerie, USERA, Aimee, PALERMO, Mark, HOLLINGWORTH, Gregory John, JONES, Darryl

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BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 von PELLE, XAVIER FRANCOIS ANDRE, DODD, STEPHANIE KAY, MARZINZIK, ANDREAS, SCHOEPFER, JOSEPH, JONES, DARRYL BRYNLEY, MANLEY, PAUL, FURET, PASCAL, GROTZFELD, ROBERT MARTIN, SALEM, BAHAA, JAHNKE, WOLFGANG

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