The Fbw7 Tumor Suppressor Regulates Glycogen Synthase Kinase 3 Phosphorylation-Dependent c-Myc Protein Degradation von Welcker, Markus, Orian, Amir, Jin, Jianping, Grim, Jonathan A., Harper, J. Wade, Eisenman, Robert N., Clurman, Bruce E.

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A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates c-Myc and Cell Size von Welcker, Markus, Orian, Amir, Grim, Jonathan A., Eisenman, Robert N., Clurman, Bruce E.

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Fbw7 dimerization determines the specificity and robustness of substrate degradation von Welcker, Markus, Larimore, Elizabeth A, Swanger, Jherek, Bengoechea-Alonso, Maria T, Grim, Jonathan E, Ericsson, Johan, Zheng, Ning, Clurman, Bruce E

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Fbxw7 hotspot mutations and human colon cancer: mechanistic insights from new mouse models von Grim, Jonathan E

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Deep-sea hydrothermal vent bacteria related to human pathogenic Vibrio species von Hasan, Nur A, Grim, Christopher J, Lipp, Erin K, Rivera, Irma N G, Chun, Jongsik, Haley, Bradd J, Taviani, Elisa, Choi, Seon Young, Hoq, Mozammel, Munk, A Christine, Brettin, Thomas S, Bruce, David, Challacombe, Jean F, Detter, J Chris, Han, Cliff S, Eisen, Jonathan A, Huq, Anwar, Colwell, Rita R

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Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer von Grim, Jonathan E., Knoblaugh, Sue E., Guthrie, Katherine A., Hagar, Amanda, Swanger, Jherek, Hespelt, Jessica, Delrow, Jeffrey J., Small, Tom, Grady, William M., Nakayama, Keiichi I., Clurman, Bruce E.

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Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism von Davis, Ryan J., Gönen, Mehmet, Margineantu, Daciana H., Handeli, Shlomo, Swanger, Jherek, Hoellerbauer, Pia, Paddison, Patrick J., Gu, Haiwei, Raftery, Daniel, Grim, Jonathan E., Hockenbery, David M., Margolin, Adam A., Clurman, Bruce E.

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Isoform- and Cell Cycle-Dependent Substrate Degradation by the Fbw7 Ubiquitin Ligase von Grim, Jonathan E., Gustafson, Michael P., Hirata, Roli K., Hagar, Amanda C., Swanger, Jherek, Walcker, Markus, Hwang, Harry C., Ericsson, Johan, Russell, David W., Clurman, Bruce E.

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The Dynamic International Prognostic Scoring System for myelofibrosis predicts outcomes after hematopoietic cell transplantation von Scott, Bart L., Gooley, Ted A., Sorror, Mohamed L., Rezvani, Andrew R., Linenberger, Michael L., Grim, Jonathan, Sandmaier, Brenda M., Myerson, David, Chauncey, Thomas R., Storb, Rainer, Buxhofer-Ausch, Veronika, Radich, Jerald P., Appelbaum, Frederick R., Deeg, H. Joachim

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A (heat) shocking development: FBXW7 loss unleashes HSF1 to drive melanoma invasion and metastasis von Cho, Eunpi, Grim, Jonathan E.

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Multisite Phosphorylation by Cdk2 and GSK3 Controls Cyclin E Degradation von Welcker, Markus, Singer, Jeffrey, Loeb, Keith R., Grim, Jonathan, Bloecher, Andrew, Gurien-West, Mark, Clurman, Bruce E., Roberts, James M.

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Abstract 17170: Does Cardiopulmonary Bypass Provide Adequate End-Organ Perfusion? von Koprivanac, Marijan, Aly, Ahmed, Magruder, Jonathan, Acker, Andrew, Grim, Joshua, acker, michael, Cevasko, Marisa, Desai, Nimesh

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HERIZON-GEA-01: Zanidatamab + chemo ± tislelizumab for 1L treatment of HER2-positive gastroesophageal adenocarcinoma von Tabernero, Josep, Shen, Lin, Elimova, Elena, Ku, Geoffrey, Liu, Tianshu, Shitara, Kohei, Lin, Xiao, Boyken, Lisa, Li, Huiyan, Grim, Jonathan, Ajani, Jaffer

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A (heat) shocking development: FBXW 7 loss unleashes HSF 1 to drive melanoma invasion and metastasis von Cho, Eunpi, Grim, Jonathan E.

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Research Note: Effect of butyric acid glycerol esters on ileal and cecal mucosal and luminal microbiota in chickens challenged with Eimeria maxima von Proszkowiec-Weglarz, Monika, Miska, Katarzyna B, Schreier, Lori L, Grim, Christopher J, Jarvis, Karen G, Shao, Jonathan, Vaessen, Stefan, Sygall, Richard, Jenkins, Mark C, Kahl, Stanislaw, Russell, Beverly

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Research Note: Effect of butyric acid glycerol esters on ileal and cecal mucosal and luminal microbiota in chickens challenged with Eimeria maxima1 von Proszkowiec-Weglarz, Monika, Miska, Katarzyna B., Schreier, Lori L., Grim, Christopher J., Jarvis, Karen G., Shao, Jonathan, Vaessen, Stefan, Sygall, Richard, Jenkins, Mark C., Kahl, Stanislaw, Russell, Beverly

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Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice von Loeb, Keith R., Hughes, Bridget T., Fissel, Brian M., Osteen, Nyka J., Knoblaugh, Sue E., Grim, Jonathan E., Drury, Luke J., Sarver, Aaron, Dupuy, Adam J., Clurman, Bruce E.

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Mantle cell lymphoma relapsed after autologous stem cell transplantation: a single-center experience von Wu, Aaron, Graf, Solomon A, Burwick, Nicholas, Grim, Jonathan E, Dong, Zhao Ming, Richard, Robert E, Chauncey, Thomas R

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors von O'Neil, Jennifer, Grim, Jonathan, Strack, Peter, Rao, Sudhir, Tibbitts, Deanne, Winter, Christopher, Hardwick, James, Welcker, Markus, Meijerink, Jules P, Pieters, Rob, Draetta, Giulio, Sears, Rosalie, Clurman, Bruce E, Look, A Thomas

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Targeted therapy in gastroesophageal cancers: past, present and future von Woo, Janghee, Cohen, Stacey A., Grim, Jonathan E.

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