Proton nuclear magnetic resonance study of the biologically active peptide analog [Pro2]thymopentin von Griffith, Guy K., Huang, Dee-Hua, Nettesheim, David G., Heavner, George A., Krishna, N. Rama

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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations von Liu, Jimmy Z, van Sommeren, Suzanne, Huang, Hailiang, Ng, Siew C, Alberts, Rudi, Takahashi, Atsushi, Ripke, Stephan, Lee, James C, Jostins, Luke, Shah, Tejas, Abedian, Shifteh, Cheon, Jae Hee, Cho, Judy, Daryani, Naser E, Franke, Lude, Fuyuno, Yuta, Hart, Ailsa, Juyal, Ramesh C, Juyal, Garima, Kim, Won Ho, Morris, Andrew P, Poustchi, Hossein, Newman, William G, Midha, Vandana, Orchard, Timothy R, Vahedi, Homayon, Sood, Ajit, Sung, Joseph J Y, Malekzadeh, Reza, Westra, Harm-Jan, Yamazaki, Keiko, Yang, Suk-Kyun, Barrett, Jeffrey C, Franke, Andre, Alizadeh, Behrooz Z, Parkes, Miles, B K, Thelma, Daly, Mark J, Kubo, Michiaki, Anderson, Carl A, Weersma, Rinse K

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Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives von Raygoza Garay, Juan Antonio, Turpin, Williams, Lee, Sun-Ho, Smith, Michelle I., Goethel, Ashleigh, Griffiths, Anne M., Moayyedi, Paul, Espin-Garcia, Osvaldo, Abreu, Maria, Aumais, Guy L., Bernstein, Charles N., Biron, Irit A., Cino, Maria, Deslandres, Colette, Dotan, Iris, El-Matary, Wael, Feagan, Brian, Guttman, David S., Huynh, Hien, Dieleman, Levinus A., Hyams, Jeffrey S., Jacobson, Kevan, Mack, David, Marshall, John K., Otley, Anthony, Panaccione, Remo, Ropeleski, Mark, Silverberg, Mark S., Steinhart, A. Hillary, Turner, Dan, Yerushalmi, Baruch, Paterson, Andrew D., Xu, Wei, Abreu, Maria, Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Levinus A., Feagan, Brian, Griffiths, Anne, Guttman, David, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O., Madsen, Karen, Marshall, John, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark, Snapper, Scott, Stadnyk, Andy, Steinhart, Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien, Hyams, Jeffrey S., Mack, David, McGrath, Jerry, Otley, Anthony, Panancionne, Remo, Croitoru, Kenneth

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Disease-specific ACMG/AMP guidelines improve sequence variant interpretation for hearing loss von Patel, Mayher J., DiStefano, Marina T., Oza, Andrea M., Hughes, Madeline Y., Wilcox, Emma H., Hemphill, Sarah E., Cushman, Brandon J., Grant, Andrew R., Siegert, Rebecca K., Shen, Jun, Chapin, Alex, Boczek, Nicole J., Schimmenti, Lisa A., Nara, Kiyomitsu, Kenna, Margaret, Azaiez, Hela, Booth, Kevin T., Avraham, Karen B., Kremer, Hannie, Griffith, Andrew J., Rehm, Heidi L., Amr, Sami S., Tayoun, Ahmad N. Abou

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Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study von Cleynen, Isabelle, PhD, Boucher, Gabrielle, MSc, Jostins, Luke, PhD, Schumm, L Philip, MA, Zeissig, Sebastian, PhD, Ahmad, Tariq, PhD, Andersen, Vibeke, Prof, Andrews, Jane M, Prof, Annese, Vito, MD, Brand, Stephan, Prof, Brant, Steven R, MD, Cho, Judy H, Prof, Daly, Mark J, Prof, Dubinsky, Marla, MD, Duerr, Richard H, Prof, Ferguson, Lynnette R, Prof, Franke, Andre, Prof, Gearry, Richard B, Prof, Goyette, Philippe, PhD, Hakonarson, Hakon, Prof, Halfvarson, Jonas, MD, Hov, Johannes R, PhD, Huang, Hailang, PhD, Kennedy, Nicholas A, PhD, Kupcinskas, Limas, Prof, Lawrance, Ian C, Prof, Lee, James C, PhD, Satsangi, Jack, Prof, Schreiber, Stephan, Prof, Théâtre, Emilie, PhD, van der Meulen-de Jong, Andrea E, MD, Weersma, Rinse K, Prof, Wilson, David C, Prof, Parkes, Miles, PhD, Vermeire, Severine, Prof, Rioux, John D, Prof, Mansfield, John, MD, Silverberg, Mark S, PhD, Radford-Smith, Graham, PhD, McGovern, Dermot P B, Prof, Barrett, Jeffrey C, Dr, Lees, Charlie W, Dr

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ClinGen expert clinical validity curation of 164 hearing loss gene–disease pairs von DiStefano, Marina T., Hemphill, Sarah E., Oza, Andrea M., Siegert, Rebecca K., Grant, Andrew R., Hughes, Madeline Y., Cushman, Brandon J., Azaiez, Hela, Booth, Kevin T., Chapin, Alex, Duzkale, Hatice, Matsunaga, Tatsuo, Shen, Jun, Zhang, Wenying, Kenna, Margaret, Schimmenti, Lisa A., Tekin, Mustafa, Rehm, Heidi L., Tayoun, Ahmad N. Abou, Amr, Sami S.

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External validation of the 4C mortality score among COVID-19 patients admitted to hospital in Ontario, Canada: a retrospective study von Jones, Aaron, Pitre, Tyler, Junek, Mats, Kapralik, Jessica, Patel, Rina, Feng, Edward, Dawson, Laura, Tsang, Jennifer L. Y., Duong, MyLinh, Ho, Terence, Beauchamp, Marla K., Costa, Andrew P., Kruisselbrink, Rebecca

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Anti-Integrin αvβ6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis von Livanos, Alexandra E., Dunn, Alexandra, Fischer, Jeremy, Ungaro, Ryan C., Turpin, Williams, Lee, Sun-Ho, Rui, Shumin, Del Valle, Diane Marie, Jougon, Julia J., Martinez-Delgado, Gustavo, Riddle, Mark S., Murray, Joseph A., Laird, Renee M., Torres, Joana, Agrawal, Manasi, Magee, Jared S., Dervieux, Thierry, Gnjatic, Sacha, Sheppard, Dean, Sands, Bruce E., Porter, Chad K., Croitoru, Kenneth, Petralia, Francesca, Abreu, Maria, Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Leo, Feagan, Brian, Griffiths, Anne, Guttman, David, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O., Madsen, Karen, Marshall, John, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark, Snapper, Scott, Stadnyk, Andy, Steinhart, Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien, Hyams, Jeff, Mack, David, McGrath, Jerry, Otley, Anthony, Panancionne, Remo, Shapiro, Jason, Shah, Samir, Leleiko, Neal S., Colombel, Jean-Frederic, Mehandru, Saurabh

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IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes von Momozawa, Yukihide, Dmitrieva, Julia, Théâtre, Emilie, Deffontaine, Valérie, Rahmouni, Souad, Charloteaux, Benoît, Crins, François, Docampo, Elisa, Elansary, Mahmoud, Gori, Ann-Stephan, Lecut, Christelle, Mariman, Rob, Mni, Myriam, Oury, Cécile, Altukhov, Ilya, Alexeev, Dmitry, Aulchenko, Yuri, Amininejad, Leila, Bouma, Gerd, Hoentjen, Frank, Löwenberg, Mark, Oldenburg, Bas, Pierik, Marieke J., vander Meulen-de Jong, Andrea E., Janneke van der Woude, C., Visschedijk, Marijn C., Lathrop, Mark, Hugot, Jean-Pierre, Weersma, Rinse K., De Vos, Martine, Franchimont, Denis, Vermeire, Severine, Kubo, Michiaki, Louis, Edouard, Georges, Michel

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Greater Rupture Risk for Familial as Compared to Sporadic Unruptured Intracranial Aneurysms von BRODERICK, Joseph P, BROWN, Robert D, MEISSNER, Irene, FOROUD, Tatiana, MOOMAW, E. Charles J, SANDER CONNOLLY, E, SAUERBECK, Laura, HORNUNG, Richard, HUSTON, John, WOO, Daniel, ANDERSON, Craig, ROULEAU, Guy, KLEINDORFER, Dawn, FLAHERTY, Matthew L

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Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis von Leibovitzh, Haim, Lee, Sun-Ho, Raygoza Garay, Juan Antonio, Espin-Garcia, Osvaldo, Xue, Mingyue, Neustaeter, Anna, Goethel, Ashleigh, Huynh, Hien Q, Griffiths, Anne M, Turner, Dan, Madsen, Karen L, Moayyedi, Paul, Steinhart, A Hillary, Silverberg, Mark S, Deslandres, Colette, Bitton, Alain, Mack, David R, Jacobson, Kevan, Cino, Maria, Aumais, Guy, Bernstein, Charles N, Panaccione, Remo, Weiss, Batia, Halfvarson, Jonas, Xu, Wei, Turpin, Williams, Croitoru, Kenneth, Abreu, Maria, Beck, Paul, Bernstein, Charles N, Croitoru, Kenneth, Dieleman, Levinus A, Feagan, Brian, Griffiths, Anne M, Guttman, David S, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O, Madsen, Karen L, Marshall, John K, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark S, Snapper, Scott, Stadnyk, Andy, Steinhart, A Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien Q, Hyams, Jeff, Mack, David R, McGrath, Jerry, Otley, Anthony, Panaccione, Remo

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Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis von Beaudoin, Mélissa, Goyette, Philippe, Boucher, Gabrielle, Lo, Ken Sin, Rivas, Manuel A, Stevens, Christine, Alikashani, Azadeh, Ladouceur, Martin, Ellinghaus, David, Törkvist, Leif, Goel, Gautam, Lagacé, Caroline, Annese, Vito, Bitton, Alain, Begun, Jakob, Brant, Steve R, Bresso, Francesca, Cho, Judy H, Duerr, Richard H, Halfvarson, Jonas, McGovern, Dermot P B, Radford-Smith, Graham, Schreiber, Stefan, Schumm, Philip L, Sharma, Yashoda, Silverberg, Mark S, Weersma, Rinse K, D'Amato, Mauro, Vermeire, Severine, Franke, Andre, Lettre, Guillaume, Xavier, Ramnik J, Daly, Mark J, Rioux, John D

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The Alzheimer’s Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-Plus): an expansion of the ADAS-Cog to improve responsiveness in MCI von Skinner, Jeannine, Carvalho, Janessa O., Potter, Guy G., Thames, April, Zelinski, Elizabeth, Crane, Paul K., Gibbons, Laura E.

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Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Highe... von Olivera, Pablo A., Martinez-Lozano, Helena, Leibovitzh, Haim, Xue, Mingyue, Neustaeter, Anna, Espin-Garcia, Osvaldo, Xu, Wei, Madsen, Karen L., Guttman, David S., Bernstein, Charles N., Yerushalmi, Baruch, Hyams, Jeffrey S., Abreu, Maria T., Marshall, John K., Wrobel, Iwona, Mack, David R., Jacobson, Kevan, Bitton, Alain, Aumais, Guy, Panacionne, Remo, Dieleman, Levinus A., Silverberg, Mark S., Steinhart, A. Hillary, Moayyedi, Paul, Turner, Dan, Griffiths, Anne M., Turpin, Williams, Lee, Sun-Ho, Croitoru, Kenneth, Abreu, Maria T., Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Levinus, Feagan, Brian, Griffiths, Anne, Guttman, David S., Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O., Madsen, Karen L., Marshall, John K., Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark S., Snapper, Scott, Stadnyk, Andy, Steinhart, A. Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien Q., Hyams, Jeff, Mack, David R., McGrath, Jerry, Otley, Anthony, Panaccione, Remo

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Inflammatory biomarkers as independent prognosticators of 28-day mortality for COVID-19 patients admitted to general medicine or ICU wards: a retrospective cohort study von Pitre, Tyler, Jones, Aaron, Su, Johnny, Helmeczi, Wryan, Xu, Grace, Lee, Catherine, Shamsuddin, Adib, Mir, Adhora, MacGregor, Sarah, Duong, MyLinh, Ho, Terence, Beauchamp, Marla K., Costa, Andrew P., Kruisselbrink, Rebecca

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Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population von Rivas, Manuel A, Avila, Brandon E, Koskela, Jukka, Huang, Hailiang, Stevens, Christine, Pirinen, Matti, Haritunians, Talin, Neale, Benjamin M, Kurki, Mitja, Ganna, Andrea, Graham, Daniel, Glaser, Benjamin, Peter, Inga, Atzmon, Gil, Barzilai, Nir, Levine, Adam P, Schiff, Elena, Pontikos, Nikolas, Weisburd, Ben, Lek, Monkol, Karczewski, Konrad J, Bloom, Jonathan, Minikel, Eric V, Petersen, Britt-Sabina, Beaugerie, Laurent, Seksik, Philippe, Cosnes, Jacques, Schreiber, Stefan, Bokemeyer, Bernd, Bethge, Johannes, Heap, Graham, Ahmad, Tariq, Plagnol, Vincent, Segal, Anthony W, Targan, Stephan, Turner, Dan, Saavalainen, Paivi, Farkkila, Martti, Kontula, Kimmo, Palotie, Aarno, Brant, Steven R, Duerr, Richard H, Silverberg, Mark S, Rioux, John D, Weersma, Rinse K, Franke, Andre, Jostins, Luke, Anderson, Carl A, Barrett, Jeffrey C, MacArthur, Daniel G, Jalas, Chaim, Sokol, Harry, Xavier, Ramnik J, Pulver, Ann, Cho, Judy H, McGovern, Dermot P B, Daly, Mark J

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Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn’s Disease von Turpin, Williams, Espin-Garcia, Osvaldo, Bedrani, Larbi, Madsen, Karen, Meddings, Jonathan B, Raygoza Garay, Juan Antonio, Silverberg, Mark S, Smith, Michelle I, Griffiths, Anne M, Moayyedi, Paul, Marshall, John K, Mack, David, Seidman, Ernest G, Ropeleski, Mark, Feagan, Brian G, Jacobson, Kevan, Turner, Dan, Walters, Thomas, Paterson, Andrew D, Xu, Wei, Croitoru, Kenneth

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Mutations in COL11A2 cause non-syndromic hearing loss (DFNA13) von Smith, Richard J.H, McGuirt, Wyman T, Prasad, Sai D, Griffith, Andrew J, Kunst, Henricus P.M, Green, Glenn E, Shpargel, Karl B, Runge, Christina, Huybrechts, Christy, Mueller, Robert F, Lynch, Eric, King, Mary-Claire, Brunner, Han G, Cremers, Cor W.R.J, Takanosu, Masamine, Li, Shi-Wu, Arita, Machiko, Mayne, Richard, Prockop, Darwin J, Camp, Guy Van

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HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis von Schwerk, Maria, Padoan, Benedetta, Schloer, Sebastian, Zecher, Britta F., Malsy, Jakob, Joshi, Vinita R., Möller, Kimberly J., Flomm, Jäger, Julia, Reinshagen, Konrad, Sandfort, Deborah, Steinert, Fenja, Tomuschat, Christian, Martin, Maureen P., Yuki, Yuko, Sauter, Jürgen, Schmidt, Alexander H., Giannou, Anastasios D., Sauter, Guido, Franke, Andre, Abraham, Clara, Achkar, Jean-Paul, Alizadeh, Behrooz, Amininejad, Leila, Andersen, Vibeke, Andrews, Jane M., Baidoo, Leonard, Baldassano, Robert N., Bampton, Peter A., Bewshea, Claire, BK, Thelma, Brain, Oliver, Brand, Stephan, Cheon, Jae Hee, Chew, Angela, Cohain, Ariella, Croft, Anthony, D'Amato, Mauro, Danese, Silvio, Daryani, Naser Ebrahim, Datta, Lisa Wu, Dubinsky, Marla, Duerr, Richard H., Edwards, Cathryn, Esaki, Motohiro, Franchimont, Denis, Franke, Andre, Georges, Michel, Gieger, Christian, Glas, Jürgen, Green, Todd, Guthery, Stephen L., Hakonarson, Hakon, Hanigan, Katherine, Hayward, Nicholas K., Hong, Myhunghee, Hu, Xinli, Jazayeri, Omid, Chandra Juyal, Ramesh, Karlsen, Tom H., Kennedy, Nicholas A., Kiudelis, Gediminas, Lamb, Christopher A., de Lange, Katrina M., Leja, Marcis, Lewis, Nina, Van Limbergen, Johan, Louis, Edouard, Mansfield, John, Mowat, Craig, Nöthen, Markus, Okou, David, Orchard, Timothy R., Parkes, Miles, Prescott, Natalie J., Rahier, Jean- Francois, Regueiro, Miguel, Rieder, Florian, Schadt, Eric E., Scharl, Michael, Scott, Regan, Sharma, Yashoda, Simms, Lisa A., Song, Kyuyoung, Sood, Ajit, Spain, Sarah L., Stronati, Laura, Sung, Joseph J.Y., Torres, Esther A., Vasiliauskas, Eric, Verspaget, Hein W., De Vos, Martine, Wang, Kai, Wang, Ming-Hsi, Wei, Zhi, Whiteman, David, Wilson, David C., Zhang, Hu, Zhang, Wei, Bunders, Madeleine J.

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Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn’s disease and leads to impaired CFB cleavage and phagocytosis von Stamps, Dalton T, Dube, Shishir, Li, Dalin, Yang, Shaohong, Landers, Carol J, Mengesha, Emebet, Murali, Ramachandran, Potdar, Alka A, Wolf, Andrea J, Botwin, Gregory J, Khrom, Michelle, Faubion, William A, Sandler, Robert S, Sartor, R Balfour, Brant, Steven R, Rioux, John D, Schumm, L Philip, Silverberg, Mark S, Zaghiyan, Karen, Melmed, Gil Y, Vasiliauskas, Eric A, Syal, Gaurav, Bonthala, Nirupama N, Targan, Stephan R, Michelsen, Kathrin S, Ahmad, Tariq, Amininejad, Leila, Andersen, Vibeke, Aumais, Guy, Baidoo, Leonard, Bayless, Theodore M, Bethge, Johannes, Boucher, Gabrielle, Brand, Stephan, Chew, Angela, Cho, Judy H, Cohain, Ariella, Jong, Dirk De, Denson, Lee A, Dewit, Olivier, D'Inca, Renata, Edwards, Cathryn, Ellinghaus, David, Festen, Eleonora A, Florin, Tim, Gieger, Christian, Goyette, Philippe, Green, Todd, Griffiths, Anne M, Hakonarson, Hakon, Hanigan, Katherine, Hart, Ailsa, Hayward, Nicholas K, Hugot, Jean-Pierre, Hui, Ken Y, Imielinski, Marcin, Jonaitis, Laimas, Jostins, Luke, Kiudelis, Gediminas, Krishnaprasad, Krupa, Kugathasan, Subra, Lee, James C, Lees, Charlie W, Leja, Marcis, Louis, Edouard, Mitrovic, Mitja, Ng, Aylwin, Ng, Siew C, Evelyn Ng, Sok Meng, Nikolaus, Susanna, Oikonomou, Ioannis, Phillips, Anne, Ponsioen, Cyriel Y, Prescott, Natalie J, Raychaudhuri, Soumya, Rieder, Florian, Rioux, John D, Ripke, Stephan, Russell, Richard K, Sanderson, Jeremy D, Satsangi, Jack, Schreiber, Stefan, Philip Schumm, L, Scott, Regan, Silverberg, Mark S, Simms, Lisa A, Spain, Sarah L, Sventoraityte, Jurgita, Torkvist, Leif, Tremelling, Mark, Vasiliauskas, Eric, Vermeire, Severine, Walters, Thomas, Wang, Kai, Wang, Ming-Hsi, Wei, Zhi, Winkelmann, Juliane, Zhang, Clarence K, Zhang, Wei, Zhao, Zhen Z

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