Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS) von Cox, Laura E, Ferraiuolo, Laura, Goodall, Emily F, Heath, Paul R, Higginbottom, Adrian, Mortiboys, Heather, Hollinger, Hannah C, Hartley, Judith A, Brockington, Alice, Burness, Christine E, Morrison, Karen E, Wharton, Stephen B, Grierson, Andrew J, Ince, Paul G, Kirby, Janine, Shaw, Pamela J

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The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy von Webster, Christopher P, Smith, Emma F, Bauer, Claudia S, Moller, Annekathrin, Hautbergue, Guillaume M, Ferraiuolo, Laura, Myszczynska, Monika A, Higginbottom, Adrian, Walsh, Matthew J, Whitworth, Alexander J, Kaspar, Brian K, Meyer, Kathrin, Shaw, Pamela J, Grierson, Andrew J, De Vos, Kurt J

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Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish von Chapman, Anna L, Bennett, Ellen J, Ramesh, Tennore M, De Vos, Kurt J, Grierson, Andrew J

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Role of Axonal Transport in Neurodegenerative Diseases von DE VOS, Kurt J, GRIERSON, Andrew J, ACKERLEY, Steven, MILLER, Christopher C. J

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The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type von Richardson, Katie, Allen, Scott P, Mortiboys, Heather, Grierson, Andrew J, Wharton, Stephen B, Ince, Paul G, Shaw, Pamela J, Heath, Paul R

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Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis von Allen, Scott P, Rajan, Sandeep, Duffy, Lynn, Mortiboys, Heather, Higginbottom, Adrian, Grierson, Andrew J, Shaw, Pamela J

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Mitochondrial Function and Actin Regulate Dynamin-Related Protein 1-Dependent Mitochondrial Fission von De Vos, Kurt J., Allan, Victoria J., Grierson, Andrew J., Sheetz, Michael P.

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Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content von De Vos, Kurt J., Chapman, Anna L., Tennant, Maria E., Manser, Catherine, Tudor, Elizabeth L., Lau, Kwok-Fai, Brownlees, Janet, Ackerley, Steven, Shaw, Pamela J., McLoughlin, Declan M., Shaw, Christopher E., Leigh, P. Nigel, Miller, Christopher C.J., Grierson, Andrew J.

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An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD von Bauer, Claudia S., Cohen, Rebecca N., Sironi, Francesca, Livesey, Matthew R., Gillingwater, Thomas H., Highley, J. Robin, Fillingham, Daniel J., Coldicott, Ian, Smith, Emma F., Gibson, Yolanda B., Webster, Christopher P., Grierson, Andrew J., Bendotti, Caterina, De Vos, Kurt J.

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S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis von Mead, Richard J., Higginbottom, Adrian, Allen, Scott P., Kirby, Janine, Bennett, Ellen, Barber, Siân C., Heath, Paul R., Coluccia, Antonio, Patel, Neelam, Gardner, Iain, Brancale, Andrea, Grierson, Andrew J., Shaw, Pamela J.

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Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish von Gibson, Josie F, Prajsnar, Tomasz K, Hill, Christopher J, Tooke, Amy K, Serba, Justyna J, Tonge, Rebecca D, Foster, Simon J, Grierson, Andrew J, Ingham, Philip W, Renshaw, Stephen A, Johnston, Simon A

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Altered age-related changes in bioenergetic properties and mitochondrial morphology in fibroblasts from sporadic amyotrophic lateral sclerosis patients von Allen, Scott P, Duffy, Lynn M, Shaw, Pamela J, Grierson, Andrew J

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Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development von Derrick, Christopher J., Pollitt, Eric J. G., Uruchurtu, Ashley Sanchez Sevilla, Hussein, Farah, Grierson, Andrew J., Noel, Emily S.

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C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy von Webster, Christopher P., Smith, Emma F., Grierson, Andrew J., De Vos, Kurt J.

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Discovery of Western European R1b1a2 Y chromosome variants in 1000 genomes project data: an online community approach von Rocca, Richard A, Magoon, Gregory, Reynolds, David F, Krahn, Thomas, Tilroe, Vincent O, Op den Velde Boots, Peter M, Grierson, Andrew J

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Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation von Bauer, Claudia S, Webster, Christopher P, Shaw, Allan C, Kok, Jannigje R, Castelli, Lydia M, Lin, Ya-Hui, Smith, Emma F, Illanes-Álvarez, Francisco, Higginbottom, Adrian, Shaw, Pamela J, Azzouz, Mimoun, Ferraiuolo, Laura, Hautbergue, Guillaume M, Grierson, Andrew J, De Vos, Kurt J

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Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients von Kasher, Paul R, De Vos, Kurt J, Wharton, Stephen B, Manser, Catherine, Bennett, Ellen J, Bingley, Megan, Wood, Jonathan D, Milner, Roy, McDermott, Christopher J, Miller, Christopher C.J, Shaw, Pamela J, Grierson, Andrew J

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Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar hypoplasia von KASHER, Paul R, NAMAVAR, Yasmin, VAN TIJN, Paula, FLUITER, Kees, SIZAROV, Aleksander, KAMERMANS, Maarten, GRIERSON, Andrew J, ZIVKOVIC, Danica, BAAS, Frank

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AAV9-mediated central nervous system-targeted gene delivery via cisterna magna route in mice von Lukashchuk, Vera, Lewis, Katherine E, Coldicott, Ian, Grierson, Andrew J, Azzouz, Mimoun

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Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS von Ciervo, Yuri, Gatto, Noemi, Allen, Chloe, Grierson, Andrew, Ferraiuolo, Laura, Mead, Richard J., Shaw, Pamela J.

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