Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors von Sommer, Anette, Kopitz, Charlotte, Schatz, Christoph A, Nising, Carl F, Mahlert, Christoph, Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Hammer, Stefanie, Greven, Simone, Schuhmacher, Joachim, Braun, Manuela, Zierz, Ruprecht, Wittemer-Rump, Sabine, Harrenga, Axel, Dittmer, Frank, Reetz, Frank, Apeler, Heiner, Jautelat, Rolf, Huynh, Hung, Ziegelbauer, Karl, Kreft, Bertolt

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Site-specific modification of ED-B-targeting antibody using intein-fusion technology von Möhlmann, Sina, Bringmann, Peter, Greven, Simone, Harrenga, Axel

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A study on the trastuzumab conjugation at tyrosine using diazonium salts von Griebenow, Nils, Greven, Simone, Lobell, Mario, Dilmaç, Alicia M, Bräse, Stefan

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Technical considerations for the implementation of the multi-attribute-method by mass spectrometry in a quality control laboratory von Pohl, Thomas, Gervais, Annick, Dirksen, Eef H.C., D'Alessio, Valerio, Bechtold-Peters, Karoline, Burkitt, Will, Cao, Li, Greven, Simone, Lennard, Andrew, Li, Xue, Lössner, Christopher, Niu, Ben, Reusch, Dietmar, O'Riordan, Tomás, Shearer, Justin W., Spencer, David, Xu, Wei, Yi, Linda

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Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads von Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Rebstock, Anne-Sophie, Johannes, Sarah, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah

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A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy von Böhnke, Niels, Berger, Markus, Griebenow, Nils, Rottmann, Antje, Erkelenz, Michael, Hammer, Stefanie, Berndt, Sandra, Günther, Judith, Wengner, Antje M., Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah, Barak, Naomi, Bömer, Ulf, Hillig, Roman C., Eberspaecher, Uwe, Weiske, Jörg, Giese, Anja, Mumberg, Dominik, Nising, Carl Friedrich, Weinmann, Hilmar, Sommer, Anette

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Compliance and regulatory considerations for the implementation of the multi-attribute-method by mass spectrometry in a quality control laboratory von Gervais, Annick, Dirksen, Eef H.C., Pohl, Thomas, Bechtold-Peters, Karoline, Burkitt, Will, D'Alessio, Valerio, Greven, Simone, Lennard, Andrew, Li, Xue, Lössner, Christopher, Niu, Ben, Reusch, Dietmar, O'Riordan, Tomás, Shearer, Justin W., Spencer, David, Xu, Wei, Yi, Linda

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Site-Specific Conjugation of Peptides and Proteins via Rebridging of Disulfide Bonds Using the Thiol–Yne Coupling Reaction von Griebenow, Nils, Dilmaç, Alicia M, Greven, Simone, Bräse, Stefan

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Antibody–Drug Conjugates with Pyrrole‐Based KSP Inhibitors as the Payload Class von Lerchen, Hans‐Georg, Wittrock, Sven, Stelte‐Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Griebenow, Nils, Rebstock, Anne‐Sophie, Johannes, Sarah, Cancho‐Grande, Yolanda, Mahlert, Christoph, Greven, Simone, Terjung, Carsten

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Abstract 228: KSPi-ADCs: ADCs with novel kinesin spindle protein inhibitor payloads and a tailor-made linker chemistry von Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Rebstock, Anne-Sophie, Johannes, Sarah, Marx, Leo, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Weinmann, Hilmar

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Abstract 4825: Preclinical characterization of BAY-924, a first in class ADC targeting CXCR5-positive B-cell malignancies, with a KSP inhibitor as novel payload von Johannes, Sarah, Hammer, Stefanie, Maersch, Stephan, Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Joerissen, Hannah, Ahsen, Oliver von, Schatz, Christoph, Greven, Simone, Mahlert, Christoph, Mumberg, Dominik, Lejeune, Pascale

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Front Cover: Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation (Chem. Eur. J. 35/2019) von Lerchen, Hans‐Georg, Stelte‐Ludwig, Beatrix, Berndt, Sandra, Sommer, Anette, Dietz, Lisa, Rebstock, Anne‐Sophie, Johannes, Sarah, Marx, Leo, Jörißen, Hannah, Mahlert, Christoph, Greven, Simone

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In vitro Sortagging of an Antibody Fab Fragment: Overcoming Unproductive Reactions of Sortase with Water and Lysine Side Chains von Möhlmann, Sina, Mahlert, Christoph, Greven, Simone, Scholz, Peter, Harrenga, Axel

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Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation von Lerchen, Hans‐Georg, Stelte‐Ludwig, Beatrix, Berndt, Sandra, Sommer, Anette, Dietz, Lisa, Rebstock, Anne‐Sophie, Johannes, Sarah, Marx, Leo, Jörißen, Hannah, Mahlert, Christoph, Greven, Simone

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Inside Cover: Antibody–Drug Conjugates with Pyrrole‐Based KSP Inhibitors as the Payload Class (Angew. Chem. Int. Ed. 46/2018) von Lerchen, Hans‐Georg, Wittrock, Sven, Stelte‐Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Griebenow, Nils, Rebstock, Anne‐Sophie, Johannes, Sarah, Cancho‐Grande, Yolanda, Mahlert, Christoph, Greven, Simone, Terjung, Carsten

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Abstract 1807: Anti-tumor activity of a novel structural class of NAMPT inhibitor-based ADCs in models of hematologic and solid tumor indications von Sommer, Anette, Hammer, Stefanie, Berndt, Sandra, Wengner, Antje M., Boehnke, Niels, Berger, Markus, Griebenow, Nils, Steffen, Andreas, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Giese, Anja, Quanz, Maria, Bao, Zhengzheng, Wu, Xiuli, Weinmann, Hilmar, Linden, Lars, Kreft, Bertolt, Mumberg, Dominik

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Abstract 2907: Identification and optimization of a novel NAMPT inhibitor-based ADC payload class for cancer therapy von Böhnke, Niels, Berger, Markus, Griebenow, Nils, Giese, Anja, Günther, Judith, Sommer, Anette, Hammer, Stefanie, Berndt, Sandra, Wengner, Antje M., Beier, Rudolf, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Rottmann, Antje, Erkelenz, Michael, Barak, Naomi, Bömer, Ulf, Mumber, Dominik, Kreft, Bertolt, Linden, Lars, Nising, Carl Friedrich, Weinmann, Hilmar

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IL3RA-Targeting Antibody–Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies von Kirchhoff, Dennis, Stelte-Ludwig, Beatrix, Lerchen, Hans-Georg, Wengner, Antje Margret, Ahsen, Oliver von, Buchmann, Pascale, Märsch, Stephan, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Erkelenz, Michael, Zierz, Ruprecht, Johanssen, Sandra, Mumberg, Dominik, Sommer, Anette

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Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation von Lerchen, Hans‐Georg, Stelte‐Ludwig, Beatrix, Berndt, Sandra, Sommer, Anette, Dietz, Lisa, Rebstock, Anne‐Sophie, Johannes, Sarah, Marx, Leo, Jörißen, Hannah, Mahlert, Christoph, Greven, Simone

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Abstract 3234: Development of potent and selective antibody-drug conjugates with pyrrole-based KSP inhibitors as novel payload class von Lerchen, Hans-Georg, Wittrock, Sven, Griebenow, Nils, Lobell, Mario, Rebstock, Anne-Sophie, Cancho-Grande, Yolanda, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Sommer, Anette, Berndt, Sandra, Terjung, Carsten, Apeler, Heiner, Kreft, Bertolt, Jautelat, Rolf

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