EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila von Jiang, Huaqi, Grenley, Marc O., Bravo, Maria-Jose, Blumhagen, Rachel Z., Edgar, Bruce A.

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A Platform for Rapid, Quantitative Assessment of Multiple Drug Combinations Simultaneously in Solid Tumors In Vivo von Dey, Joyoti, Kerwin, William S, Grenley, Marc O, Casalini, Joseph R, Tretyak, Ilona, Ditzler, Sally H, Thirstrup, Derek J, Frazier, Jason P, Pierce, Daniel W, Carleton, Michael, Klinghoffer, Richard A

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Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut von Jiang, Huaqi, Patel, Parthive H., Kohlmaier, Alexander, Grenley, Marc O., McEwen, Donald G., Edgar, Bruce A.

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Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition von Dey, Joyoti, Deckwerth, Thomas L., Kerwin, William S., Casalini, Joseph R., Merrell, Angela J., Grenley, Marc O., Burns, Connor, Ditzler, Sally H., Dixon, Chantel P., Beirne, Emily, Gillespie, Kate C., Kleinman, Edward F., Klinghoffer, Richard A.

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Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma von Gundle, Kenneth R., Deutsch, Gary B., Goodman, Howard J., Pollack, Seth M., Thompson, Matthew J., Davis, Jessica L., Lee, Mee-Young, Ramirez, Daniel C., Kerwin, William, Bertout, Jessica A., Grenley, Marc O., Sottero, Kimberly H. W., Beirne, Emily, Frazier, Jason, Dey, Joyoti, Ellison, Micah, Klinghoffer, Richard A., Maki, Robert G.

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Multidrug Analyses in Patients Distinguish Efficacious Cancer Agents Based on Both Tumor Cell Killing and Immunomodulation von Frazier, Jason P, Bertout, Jessica A, Kerwin, William S, Moreno-Gonzalez, Alicia, Casalini, Joey R, Grenley, Marc O, Beirne, Emily, Watts, Kori L, Keener, Andy, Thirstrup, Derek J, Tretyak, Ilona, Ditzler, Sally H, Tripp, Chelsea D, Choy, Kevin, Gillings, Sarah, Breit, Megan N, Meleo, Karri A, Rizzo, Vanessa, Herrera, Chamisa L, Perry, James A, Amaravadi, Ravi K, Olson, James M, Klinghoffer, Richard A

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Minimally invasive in tumor multidrug comparative analysis with contrast-enhanced MRI in mice von Kerwin, William S., Tretyak, Ilona, Grenley, Marc O., You, Sheng, Hatton, Beryl A., Moreno-Gonzalez, Alicia, Thirstrup, Derek J., Klinghoffer, Richard A.

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Abstract 1724: Microinjection of Nectin-4/CD137 tumor-targeted immune cell agonist (TICA™) activates the local tumor microenvironment von Lahdenranta, Johanna, Blakemore, Stephen J., Hurov, Kristen, Grenley, Marc O., Upadhyaya, Punit, Campbell, Carly, Repash, Elizabeth, Haines, Eric, Brandish, Philip E., Klinghoffer, Richard A., Keen, Nicholas

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Multiplexed trackable intratumor microdosing of the investigational STING agonist TAK-676 alone and in combination in the native tumor microenvironment of patients with head and ne... von Rajasekaran, Karthik, Ow, Thomas J, Nathan, Cherie-Ann, Tang, Alice L, Mehta, Vikas, Schiff, Bradley A, Pang, John, Van Zante, Annemieke, Turner, Atticus, Grenley, Marc O, Burns, Connor, Merrell, Angela, Beirne, Emily, Derry, Jonathan, Schauer, Nathan J, Frazier, Jason, Jenkins, Wendy, Gregory, Richard C., Lineberry, Neil, Klinghoffer, Richard

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Abstract CT142: Multidrug analyses in cancer patients via intratumoral microdosing with CIVO: A functional approach to precision oncology von Thompson, Matthew J., Davidson, Darin J., Bertout, Jessica A., Sottero, Kimberly H., Grenley, Marc O., Beirne, Emily, Klinghoffer, Richard A., Pollack, Seth M.

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Multidrug analyses in cancer patients via intratumoral microdosing with CIVO: A microinjection technology for phase 0 drug investigation von Klinghoffer, Richard, Thompson, Matthew J, Davidson, Darin J, Bertout, Jessica A, Sottero, Kimberly H W, Grenley, Marc O, Beirne, Emily, Pollack, Seth

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Abstract 2155: High-plex spatial profiling analysis of multidrug CIVO microdose studies in cancer patients von Deutsch, Gary B., Pollack, Seth M., Thompson, Matthew J., Gundle, Kenneth R., Bertout, Jessica A., Frazier, Jason P., Beirne, Emily, Grenley, Marc O., Gong, JingJing, Liang, Yan, Beechem, Joseph M., Klinghoffer, Richard A., Maki, Robert G.

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Abstract CT216: A phase 0 master protocol utilizing a novel intratumoral microdosing approach for simultaneously evaluating multiple drugs and drug combinations in patients with so... von Rajasekaran, Karthik, Newman, Jason G., Maki, Robert G., Ow, Thomas J., Mehta, Vikas, Gundle, Kenneth R., Clayburgh, Daniel R., Li, Ryan J., Porosnicu, Mercedes, Nathan, Cherie-Ann O., Tang, Alice, Hatton, Beryl A., Sottero, Kimberly H., Kung, Gloria, Grenley, Marc O., Anderson, Kirsten, Klinghoffer, Richard A.

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Abstract CT139: Intratumoral (IT) microdosing of the investigational SUMOylation Inhibitor TAK-981 in a phase 0 CIVO trial demonstrates the reactivation of type I Interferon (IFN1)... von Houlton, Jeffrey, Cash, Harrison, Xu, Haodong, Swiecicki, Paul L., Casper, Keith, Chinn, Steven B., Clayburgh, Daniel R., Li, Ryan J., Christian, Robert J., Halfpenny, Aaron, van Zante, Annemieke, Hatton, Beryl A., Sottero, Kimberly, Grenley, Marc O., Burns, Connor, Frazier, Jason, Derry, Jonathan, Kung, Gloria, Beirne, Emily, Schauer, Nathan J., Turner, Atticus, Jenkins, Wendy, Anderson, Kirsten, Klinghoffer, Richard A., Huszar, Dennis, Berger, Allison, Kannan, Karuppiah

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Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment von Gundle, Kenneth R, Rajasekaran, Karthik, Houlton, Jeffrey, Deutsch, Gary B, Ow, Thomas J, Maki, Robert G, Pang, John, Nathan, Cherie-Ann O, Clayburgh, Daniel, Newman, Jason G, Brinkmann, Elyse, Wagner, Michael J, Pollack, Seth M, Thompson, Matthew J, Li, Ryan J, Mehta, Vikas, Schiff, Bradley A, Wenig, Barry I, Swiecicki, Paul L, Tang, Alice L, Davis, Jessica L, van Zante, Annemieke, Bertout, Jessica A, Jenkins, Wendy, Turner, Atticus, Grenley, Marc, Burns, Connor, Frazier, Jason P, Merrell, Angela, Sottero, Kimberly H W, Derry, Jonathan M J, Gillespie, Kate C, Mills, Bre, Klinghoffer, Richard A

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