Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML von Haubner, S., Perna, F., Köhnke, T., Schmidt, C., Berman, S., Augsberger, C., Schnorfeil, F. M., Krupka, C., Lichtenegger, F. S., Liu, X., Kerbs, P., Schneider, S., Metzeler, K. H., Spiekermann, K., Hiddemann, W., Greif, P. A., Herold, T., Sadelain, M., Subklewe, M.

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Molecular alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients von von der Heide, E K, Neumann, M, Vosberg, S, James, A R, Schroeder, M P, Ortiz-Tanchez, J, Isaakidis, K, Schlee, C, Luther, M, Jöhrens, K, Anagnostopoulos, I, Mochmann, L H, Nowak, D, Hofmann, W K, Greif, P A, Baldus, C D

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Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia von Reiter, K, Polzer, H, Krupka, C, Maiser, A, Vick, B, Rothenberg-Thurley, M, Metzeler, K H, Dörfel, D, Salih, H R, Jung, G, Nößner, E, Jeremias, I, Hiddemann, W, Leonhardt, H, Spiekermann, K, Subklewe, M, Greif, P A

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Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing von Greif, P A, Eck, S H, Konstandin, N P, Benet-Pagès, A, Ksienzyk, B, Dufour, A, Vetter, A T, Popp, H D, Lorenz-Depiereux, B, Meitinger, T, Bohlander, S K, Strom, T M

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Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape von Silva, P, Neumann, M, Schroeder, M P, Vosberg, S, Schlee, C, Isaakidis, K, Ortiz-Tanchez, J, Fransecky, L R, Hartung, T, Türkmen, S, Graf, A, Krebs, S, Blum, H, Müller-Tidow, C, Thiede, C, Ehninger, G, Serve, H, Hecht, J, Berdel, W E, Greif, P A, Röllig, C, Baldus, C D

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The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice von Deshpande, A J, Rouhi, A, Lin, Y, Stadler, C, Greif, P A, Arseni, N, Opatz, S, Quintanilla-Fend, L, Holzmann, K, Hiddemann, W, Döhner, K, Döhner, H, Xu, G, Armstrong, S A, Bohlander, S K, Buske, C

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The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models von Dutta, S, Krause, A, Vosberg, S, Herold, T, Ksienzyk, B, Quintanilla-Martinez, L, Tizazu, B, Chopra, M, Graf, A, Krebs, S, Blum, H, Greif, P A, Vetter, A, Metzeler, K, Rothenberg-Thurley, M, Schneider, M R, Dahlhoff, M, Spiekermann, K, Zimber-Strobl, U, Wolf, E, Bohlander, S K

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The leukemogenic CALM AF10 fusion protein alters the subcellular localization of the lymphoid regulator Ikaros von Greif, P A, Tizazu, B, Krause, A, Kremmer, E, Bohlander, S K

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Somatic mutations in acute promyelocytic leukemia (APL) identified by exome sequencing von Greif, P A, Yaghmaie, M, Konstandin, N P, Ksienzyk, B, Alimoghaddam, K, Ghavamzadeh, A, Hauser, A, Graf, A, Krebs, S, Blum, H, Bohlander, S K

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Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C EBPα von Bararia, D, Trivedi, A K, Zada, A A Peer, Greif, P A, Mulaw, M A, Christopeit, M, Hiddemann, W, Bohlander, S K, Behre, G

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P-253 Unbalanced translocation t(5;17) resulting in a TP53 loss as recurrent aberration in myelodysplastic syndrome with complex karyotype von Vajen, B, Greif, P, Edeling, M, Thomay, K, Steinemann, D, Schlegelberger, B, Göhring, G

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FAT1 expression and mutations in adult acute lymphoblastic leukemia von Neumann, M, Seehawer, M, Schlee, C, Vosberg, S, Heesch, S, von der Heide, E K, Graf, A, Krebs, S, Blum, H, Gökbuget, N, Schwartz, S, Hoelzer, D, Greif, P A, Baldus, C D

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P479: DNA METHYLATION PROFILING REFINES THE PROGNOSTIC CLASSIFICATION OF ACUTE MYELOID LEUKEMIA PATIENTS TREATED WITH INTENSIVE CHEMOTHERAPY von Vosberg, S., Ohnmacht, A., Moser, C., Arneth, A., Jurinovic, V., Metzeler, K. H., Sauerland, M. C., Görlich, D., Berdel, W. E., Braess, J., Amler, S., Krug, U., Hiddemann, W., Spiekermann, K., Oakes, C. C., Menden, M. P., Herold, T., Greif, P. A.

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RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes von GREIF, Philipp A, KONSTANDIN, Nikola P, BRAESS, Jan, SAUERLAND, Maria Cristina, BERDEL, Wolfgang E, BÜCHNER, Thomas, WOERMANN, Bernhard J, HIDDEMANN, Wolfgang, SPIEKERMANN, Karsten, BOHLANDER, Stefan K, METZELER, Klaus H, HEROLD, Tobias, PASALIC, Zlatana, KSIENZYK, Bianka, DUFOUR, Annika, SCHNEIDER, Friederike, SCHNEIDER, Stephanie, KAKADIA, Purvi M

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Panel-guided personalized medicine in metastatic breast and gynecological cancer: First experiences at the Comprehensive Cancer Centre Munich and clinical relevant changes over tim... von Sultova, E., Westphalen, C.B., Jung, A., Kirchner, T., Mayr, D., Heinemann, V., Metzeler, K., Greif, P.A., Trillsch, F., Mahner, S., Harbeck, N., Wuerstlein, R.

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FHL2 interacts with CALM and is highly expressed in acute erythroid leukemia von Pašaliç, Z, Greif, P A, Jurinoviç, V, Mulaw, M, Kakadia, P M, Tizazu, B, Fröhlich-Archangelo, L, Krause, A, Bohlander, S K

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P11.09.A SIGNIFICANCE OF MOLECULAR DIAGNOSTICS FOR THERAPEUTIC DECISION MAKING IN RECURRENT GLIOMA von Blobner, J, Dengler, L, Blobner, S, Eberle, C, Weller, J, Teske, N, Karschnia, P, Rühlmann, K, Heinrich, K, Ziemann, F, Greif, P A, Jeremias, I, Wuerstlein, R, Hasselmann, K, Dorostkar, M, Harter, P N, Quach, S, Stoecklein, V, Albert, N L, Niyazi, M, Tonn, J, Thon, N, Westphalen, B C, Baumgarten, L

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Tricking the devil with an engineered protein switch for ex vivo blood cell production von Windisch, R., Soliman, S., Hoffmann, A., Chen-Wichmann, L., Kellner, C., Redondo-Monte, E., Hartmann, L., Schneider, S., Bernhagen, J., Klump, H., Humpe, A., Greif, P., Wichmann, C.

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Hematopoietic Stem/Progenitor Cells and Engineering: FROM HARMFUL TO USEFUL: EXPLOITING A LEUKEMIC TRANSCRIPTION FACTOR FOR LARGE-SCALE EX VIVO MANUFACTURE OF HUMAN MACROPHAGES von Windisch, R., Soliman, S., Hoffmann, A., Chen-Wichmann, L., Lutz, S., Kellner, C., Redondo-Monte, E., Vosberg, S., Hartmann, L., Schneider, S., Beier, F., Strobl, C., Weigert, O., Peipp, M., Schuendeln, M., Bernhagen, J., Humpe, A., Brendel, C., Klump, H., Greif, P., Wichmann, C.

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Converting a leukemic transcription factor into a powerful tool for large-scale ex vivo production of human phagocytes von Windisch, R., Soliman, S., Hoffmann, A., Chen-Wichmann, L., Lutz, S., Kellner, C., Redondo-Monte, E., Vosberg, S., Hartmann, L., Schneider, S., Beier, F., Strobl, C., Weigert, O., Schuendeln, M., Bernhagen, J., Humpe, A., Brendel, C., Klump, H., Greif, P., Wichmann, C.

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