The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy von Schaer, David A, Geeganage, Sandaruwan, Amaladas, Nelusha, Lu, Zhao Hai, Rasmussen, Erik R, Sonyi, Andreas, Chin, Darin, Capen, Andrew, Li, Yanxia, Meyer, Catalina M, Jones, Bonita D, Huang, Xiaodong, Luo, Shuang, Carpenito, Carmine, Roth, Kenneth D, Nikolayev, Alexander, Tan, Bo, Brahmachary, Manisha, Chodavarapu, Krishna, Dorsey, Frank C, Manro, Jason R, Doman, Thompson N, Donoho, Gregory P, Surguladze, David, Hall, Gerald E, Kalos, Michael, Novosiadly, Ruslan D

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer von CARPTEN, John D, FABER, Andrew L, UHLIK, Mark, LIN, Aimin, JIAN DU, QIAN, Yue-Wei, ZECKNER, Douglas J, TUCKER-KELLOGG, Greg, TOUCHMAN, Jeffrey, PATEL, Ketan, MOUSSES, Spyro, BITTNER, Michael, HORN, Candice, SCHEVITZ, Richard, LAI, Mei-Huei T, BLANCHARD, Kerry L, THOMAS, James E, DONOHO, Gregory P, BRIGGS, Stephen L, ROBBINS, Christiane M, HOSTETTER, Galen, BOGUSLAWSKI, Sophie, MOSES, Tracy Y, SAVAGE, Stephanie

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Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth von Smith, Michele C, Mader, Mary M, Cook, James A, Iversen, Philip, Ajamie, Rose, Perkins, Everett, Bloem, Laura, Yip, Yvonne Y, Barda, David A, Waid, Philip P, Zeckner, Douglas J, Young, Debra A, Sanchez-Felix, Manuel, Donoho, Gregory P, Wacheck, Volker

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A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models von Yin, Tinggui, Lallena, Maria J, Kreklau, Emiko L, Fales, Kevin R, Carballares, Santiago, Torrres, Raquel, Wishart, Graham N, Ajamie, Rose T, Cronier, Damien M, Iversen, Phillip W, Meier, Timothy I, Foreman, Robert T, Zeckner, Douglas, Sissons, Sean E, Halstead, Bart W, Lin, Aimee B, Donoho, Gregory P, Qian, Yuewei, Li, Shuyu, Wu, Song, Aggarwal, Amit, Ye, Xiang S, Starling, James J, Gaynor, Richard B, de Dios, Alfonso, Du, Jian

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Direct analysis of PI(3,4,5)P3 using liquid chromatography electrospray ionization tandem mass spectrometry von Bui, Hai H., Sanders, Phillip E., Bodenmiller, Diane, Kuo, Ming Shang, Donoho, Gregory P., Fischl, Anthony S.

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Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers von Peng, Sheng-Bin, Henry, James R., Kaufman, Michael D., Lu, Wei-Ping, Smith, Bryan D., Vogeti, Subha, Rutkoski, Thomas J., Wise, Scott, Chun, Lawrence, Zhang, Youyan, Van Horn, Robert D., Yin, Tinggui, Zhang, Xiaoyi, Yadav, Vipin, Chen, Shih-Hsun, Gong, Xueqian, Ma, Xiwen, Webster, Yue, Buchanan, Sean, Mochalkin, Igor, Huber, Lysiane, Kays, Lisa, Donoho, Gregory P., Walgren, Jennie, McCann, Denis, Patel, Phenil, Conti, Ilaria, Plowman, Gregory D., Starling, James J., Flynn, Daniel L.

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Phase Ib/II Study of Enzalutamide with Samotolisib (LY3023414) or Placebo in Patients with Metastatic Castration-Resistant Prostate Cancer von Sweeney, Christopher J, Percent, Ivor J, Babu, Sunil, Cultrera, Jennifer L, Mehlhaff, Bryan A, Goodman, Oscar B, Morris, David S, Schnadig, Ian D, Albany, Costantine, Shore, Neal D, Sieber, Paul R, Guba, Susan C, Zhang, Wei, Wacheck, Volker, Donoho, Gregory P, Szpurka, Anna M, Callies, Sophie, Lin, Boris Kin, Bendell, Johanna C

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Preclinical Evaluation and Phase Ib Study of Prexasertib, a CHK1 Inhibitor, and Samotolisib (LY3023414), a Dual PI3K/mTOR Inhibitor von Hong, David S, Moore, Kathleen N, Bendell, Johanna C, Karp, Daniel D, Wang, Judy S, Ulahannan, Susanna V, Jones, Suzanne, Wu, Wenjuan, Donoho, Gregory P, Ding, Yan, Capen, Andrew, Wang, Xuejing, Bence Lin, Aimee, Patel, Manish R

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Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma von Flint, Alyssa C, Mitchell, Dana K, Angus, Steven P, Smith, Abbi E, Bessler, Waylan, Jiang, Li, Mang, Henry, Li, Xiaohong, Lu, Qingbo, Rodriguez, Brooke, Sandusky, George E, Masters, Andi R, Zhang, Chi, Dang, Pengtao, Koenig, Jenna, Johnson, Gary L, Shen, Weihua, Liu, Jiangang, Aggarwal, Amit, Donoho, Gregory P, Willard, Melinda D, Bhagwat, Shripad V, Clapp, D Wade, Rhodes, Steven D

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Direct analysis of PI(3,4,5)P 3 using liquid chromatography electrospray ionization tandem mass spectrometry von Bui, Hai H, Sanders, Phillip E, Bodenmiller, Diane, Kuo, Ming Shang, Donoho, Gregory P, Fischl, Anthony S

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Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations von Yao, Yung-Mae M, Donoho, Gregory P, Iversen, Philip W, Zhang, Youyan, Van Horn, Robert D, Forest, Amelie, Novosiadly, Ruslan D, Webster, Yue Wang, Ebert, Philip, Bray, Steven, Ting, Jason C, Aggarwal, Amit, Henry, James R, Tiu, Ramon V, Plowman, Gregory D, Peng, Sheng-Bin

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Inhibition of Tumor Growth and Metastasis in Non―Small Cell Lung Cancer by LY2801653, an Inhibitor of Several Oncokinases, Including MET von WENJUAN WU, CHEN BI, CREDILLE, Kelly M, MANRO, Jason R, PEEK, Victoria L, DONOHO, Gregory P, LEI YAN, WIJSMAN, John A, YAN, S. Betty, WALGREN, Richard A

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A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models von Ye, Xiang S, Fan, Li, Van Horn, Robert D, Nakai, Ryuichiro, Ohta, Yoshihisa, Akinaga, Shiro, Murakata, Chikara, Yamashita, Yoshinori, Yin, Tinggui, Credille, Kelly M, Donoho, Gregory P, Merzoug, Farhana F, Li, Heng, Aggarwal, Amit, Blanchard, Kerry, Westin, Eric H

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A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib von Blosser, Wayne D, Dempsey, Jack A, McNulty, Ann M, Rao, Xi, Ebert, Philip J, Lowery, Caitlin D, Iversen, Philip W, Webster, Yue Wang, Donoho, Gregory P, Gong, Xueqian, Merzoug, Farhana F, Buchanan, Sean, Boehnke, Karsten, Yu, Chunping, You, Xin Tian, Beckmann, Richard P, Wu, Wenjuan, McNeely, Samuel C, Lin, Aimee Bence, Martinez, Ricardo

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Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor von Forest, Amelie, Amatulli, Michael, Ludwig, Dale L, Damoci, Christopher B, Wang, Ying, Burns, Colleen A, Donoho, Gregory P, Zanella, Nina, Fiebig, Heinz H, Prewett, Marie C, Surguladze, David, DeLigio, James T, Houghton, Peter J, Smith, Malcolm A, Novosiadly, Ruslan

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Efficacy of low-dose oral metronomic dosing of the prodrug of gemcitabine, LY2334737, in human tumor xenografts von Pratt, Susan E, Durland-Busbice, Sara, Shepard, Robert L, Donoho, Gregory P, Starling, James J, Wickremsinhe, Enaksha R, Perkins, Everett J, Dantzig, Anne H

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Positive and Negative Regulation of the γ-Secretase Activity by Nicastrin in a Murine Model von Li, Jinhe, Fici, Gregory J., Mao, Chai-An, Myers, Richard L., Shuang, Rongqing, Donoho, Gregory P., Pauley, Adele M., Himes, Carol S., Qin, Wenning, Kola, Ismail, Merchant, Kalpana M., Nye, Jeffrey S.

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Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma von Flint, Alyssa C., Mitchell, Dana K., Angus, Steven P., Smith, Abbi E., Bessler, Waylan, Jiang, Li, Mang, Henry, Li, Xiaohong, Lu, Qingbo, Rodriguez, Brooke, Sandusky, George E., Masters, Andi R., Zhang, Chi, Dang, Pengtao, Koenig, Jenna, Johnson, Gary L., Shen, Weihua, Liu, Jiangang, Aggarwal, Amit, Donoho, Gregory P., Willard, Melinda D., Bhagwat, Shripad V., Wade Clapp, D., Rhodes, Steven D.

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Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy von Du, Jian, Yan, Lei, Torres, Raquel, Gong, Xueqian, Bian, Huimin, Marugán, Carlos, Boehnke, Karsten, Baquero, Carmen, Hui, Yu-Hua, Chapman, Sonya C, Yang, Yanzhu, Zeng, Yi, Bogner, Sarah M, Foreman, Robert T, Capen, Andrew, Donoho, Gregory P, Van Horn, Robert D, Barnard, Darlene S, Dempsey, Jack A, Beckmann, Richard P, Marshall, Mark S, Chio, Li-Chun, Qian, Yuewei, Webster, Yue W, Aggarwal, Amit, Chu, Shaoyou, Bhattachar, Shobha, Stancato, Louis F, Dowless, Michele S, Iversen, Phillip W, Manro, Jason R, Walgren, Jennie L, Halstead, Bartley W, Dieter, Matthew Z, Martinez, Ricardo, Bhagwat, Shripad V, Kreklau, Emiko L, Lallena, Maria Jose, Ye, Xiang S, Patel, Bharvin K R, Reinhard, Christoph, Plowman, Gregory D, Barda, David A, Henry, James R, Buchanan, Sean G, Campbell, Robert M

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Abstract 353: A novel molecule with profound tumor killing activity von Liu, Ling, Wrobleski, Aaron D., Yin, Yin, Zeng, Wei, Chen, Xianming, Stokell, David J., Peng, Sheng-bin, Datta-Mannan, Amita, Donoho, Gregory P., Iversen, Philip W., Hipskind, Philip, Feng, Yiqing

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