Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways von Dallosso, A R, Øster, B, Greenhough, A, Thorsen, K, Curry, T J, Owen, C, Hancock, A L, Szemes, M, Paraskeva, C, Frank, M, Andersen, C L, Malik, K

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LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity von Morgan, R G, Mortensson, E, Legge, D N, Gupta, B, Collard, T J, Greenhough, A, Williams, A C

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Optimized delivery of siRNA into 3D tumor spheroid cultures in situ von Morgan, R. G., Chambers, A. C., Legge, D. N., Coles, S. J., Greenhough, A., Williams, A. C.

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BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor β (TGF-β1) in colorectal tumour cells von Skeen, V R, Collard, T J, Southern, S L, Greenhough, A, Hague, A, Townsend, P A, Paraskeva, C, Williams, A C

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Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting canc... von Morgan, R G, Molnár, E, Jones, R F, Collard, T J, Lane, J D, Greenhough, A, Paraskeva, C, Williams, A C

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The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2 PGE signalling in colorectal adenoma cells von Greenhough, A, Wallam, C A, Hicks, D J, Moorghen, M, Williams, A C, Paraskeva, C

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Mechanism of single-stranded DNA annealing by RAD52–RPA complex von Liang, Chih-Chao, Greenhough, Luke A., Masino, Laura, Maslen, Sarah, Bajrami, Ilirjana, Tuppi, Marcel, Skehel, Mark, Taylor, Ian A., West, Stephen C.

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Researching animal research

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The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells von Greenhough, A, Wallam, C A, Hicks, D J, Moorghen, M, Williams, A C, Paraskeva, C

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Structure and function of the RAD51B–RAD51C–RAD51D–XRCC2 tumour suppressor von Greenhough, Luke A., Liang, Chih-Chao, Belan, Ondrej, Kunzelmann, Simone, Maslen, Sarah, Rodrigo-Brenni, Monica C., Anand, Roopesh, Skehel, Mark, Boulton, Simon J., West, Stephen C.

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The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2 von Patsos, H A, Hicks, D J, Dobson, R R H, Greenhough, A, Woodman, N, Lane, J D, Williams, A C, Paraskeva, C

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β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive effica... von Smartt, H J M, Greenhough, A, Ordóñez-Morán, P, Al-Kharusi, M, Collard, T J, Mariadason, J M, Huelsken, J, Williams, A C, Paraskeva, C

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The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment von Greenhough, Alexander, Smartt, Helena J.M., Moore, Amy E., Roberts, Heather R., Williams, Ann C., Paraskeva, Christos, Kaidi, Abderrahmane

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Reducing False Positives through the Application of Fluorescence Lifetime Technology: A Comparative Study Using TYK2 Kinase as a Model System von Greenhough, Luke A., Clarke, Gabriella, Phillipou, Alexander N., Mazani, Faith, Karamshi, Bhumika, Rowe, Sam, Rowland, Paul, Messenger, Cassie, Haslam, Carl P., Bingham, Ryan P., Craggs, Peter D.

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Three-Dimensional Culture of Human Embryonic Stem Cell Derived Hepatic Endoderm and Its Role in Bioartificial Liver Construction von Hay, David Colin, Medine, Claire N., Greenhough, Sebastian, Sharma, Ruchi

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Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions von Phillipou, Alexander N., Lay, Charles S., Carver, Charlotte E., Messenger, Cassie, Evans, John P., Lewis, Antonia J., Gordon, Laurie J., Mahmood, Mahnoor, Greenhough, Luke A., Sammon, Douglas, Cheng, Aaron T., Chakraborty, Syandan, Jones, Emma J., Lucas, Simon C.C., Gatfield, Kelly M., Brierley, David J., Craggs, Peter D.

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HGF/Met signalling promotes PGE2 biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells von Moore, Amy E., Greenhough, Alexander, Roberts, Heather R., Hicks, Diane J., Patsos, Helena A., Williams, Ann C., Paraskeva, Christos

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BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor [beta] (TGF-[beta]1) in colorectal tumour cells von Skeen, V R, Collard, T J, Southern, S L, Greenhough, A, Hague, A, Townsend, P A, Paraskeva, C, Williams, A C

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[beta]-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive e... von Smartt, H J M, Greenhough, A, Ordóñez-morán, P, Al-kharusi, M, Collard, T J, Mariadason, J M, Huelsken, J, Williams, A C, Paraskeva, C

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The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE sub(2) signalling in colorectal adenoma cells von Greenhough, A, Wallam, C A, Hicks, D J, Moorghen, M, Williams, A C, Paraskeva, C

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