Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer von Gonzalvez, Francois, Vincent, Sylvie, Baker, Theresa E, Gould, Alexandra E, Li, Shuai, Wardwell, Scott D, Nadworny, Sara, Ning, Yaoyu, Zhang, Sen, Huang, Wei-Sheng, Hu, Yongbo, Li, Feng, Greenfield, Matthew T, Zech, Stephan G, Das, Biplab, Narasimhan, Narayana I, Clackson, Tim, Dalgarno, David, Shakespeare, William C, Fitzgerald, Michael, Chouitar, Johara, Griffin, Robert J, Liu, Shengwu, Wong, Kwok-Kin, Zhu, Xiaotian, Rivera, Victor M

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Multilocus Binding Increases the Relaxivity of Protein-Bound MRI Contrast Agents von Zhang, Zhaoda, Greenfield, Matthew T., Spiller, Marga, McMurry, Thomas J., Lauffer, Randall B., Caravan, Peter

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Monovalent and Bivalent Fibrin-specific MRI Contrast Agents for Detection of Thrombus von Nair, Shrikumar A., Kolodziej, Andrew F., Bhole, Gandhali, Greenfield, Matthew T., McMurry, Thomas J., Caravan, Peter

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Abstract 2644: AP32788, a potent, selective inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, in preclinical models von Gonzalvez, Francois, Zhu, Xiaotian, Huang, Wei-Sheng, Baker, Theresa E., Ning, Yaoyu, Wardwell, Scott D., Nadworny, Sara, Zhang, Sen, Das, Biplab, Gong, Yongjin, Greenfield, Matthew T., Jang, Hyun G., Kohlmann, Anna, Li, Feng, Taslimi, Paul M., Tugnait, Meera, Xu, Yongjin, Ye, Emily Y., Youngsaye, Willmen W., Zech, Stephan G., Zhang, Yun, Zhou, Tianjun, Narasimhan, Narayana I., Dalgarno, David C., Shakespeare, William C., Rivera, Victor M.

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High-Relaxivity Magnetic Resonance Imaging Contrast Agents Part 2: Optimization of Inner- and Second-Sphere Relaxivity von Jacques, Vincent, Dumas, Stéphane, Sun, Wei-Chuan, Troughton, Jeffrey S, Greenfield, Matthew T, Caravan, Peter

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Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non–small cell lung cancer von Huang, Wei-Sheng, Li, Feng, Gong, Yongjin, Zhang, Yun, Youngsaye, Willmen, Xu, Yongjin, Zhu, Xiaotian, Greenfield, Matthew T., Kohlmann, Anna, Taslimi, Paul M., Toms, Angela, Zech, Stephan G., Zhou, Tianjun, Das, Biplab, Jang, Hyun G., Tugnait, Meera, Ye, Yihua E., Gonzalvez, Francois, Baker, Theresa E., Nadworny, Sara, Ning, Yaoyu, Wardwell, Scott D., Zhang, Sen, Gould, Alexandra E., Hu, Yongbo, Lane, Weston, Skene, Robert J., Zou, Hua, Clackson, Tim, Narasimhan, Narayana I., Rivera, Victor M., Dalgarno, David C., Shakespeare, William C.

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Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery von Zech, Stephan G, Kohlmann, Anna, Zhou, Tianjun, Li, Feng, Squillace, Rachel M, Parillon, Lois E, Greenfield, Matthew T, Miller, David P, Qi, Jiwei, Thomas, R. Mathew, Wang, Yihan, Xu, Yongjin, Miret, Juan J, Shakespeare, William C, Zhu, Xiaotian, Dalgarno, David C

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Heteroditopic Binding of Magnetic Resonance Contrast Agents for Increased Relaxivity von Zhang, Zhaoda, Kolodziej, Andrew F, Greenfield, Matthew T, Caravan, Peter

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The Interaction of MS-325 with Human Serum Albumin and Its Effect on Proton Relaxation Rates von Caravan, Peter, Cloutier, Normand J, Greenfield, Matthew T, McDermid, Sarah A, Dunham, Stephen U, Bulte, Jeff W. M, Amedio, John C, Looby, Richard J, Supkowski, Ronald M, Horrocks, William DeW, McMurry, Thomas J, Lauffer, Randall B

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Synthesis and Evaluation of a High Relaxivity Manganese(II)-Based MRI Contrast Agent von Troughton, Jeffrey S, Greenfield, Matthew T, Greenwood, Jaclyn M, Dumas, Stéphane, Wiethoff, Andrea J, Wang, Jufeng, Spiller, Marga, McMurry, Thomas J, Caravan, Peter

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Molecular Magnetic Resonance Imaging of Myocardial Perfusion With EP-3600, a Collagen-Specific Contrast Agent : Initial Feasibility Study in a Swine Model von SPUENTRUP, Elmar, RUHL, Karl M, CARAVAN, Peter, BOTNAR, Rene M, WIETHOFF, Andrea J, BUHL, Alexandra, JACQUES, Vincent, GREENFIELD, Matthew T, KROMBACH, Gabriele A, GÜNTHER, Rolf W, VANGEL, Mark G

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Fragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors von Kohlmann, Anna, Zech, Stephan G, Li, Feng, Zhou, Tianjun, Squillace, Rachel M, Commodore, Lois, Greenfield, Matthew T, Lu, Xiaohui, Miller, David P, Huang, Wei-Sheng, Qi, Jiwei, Thomas, R. Mathew, Wang, Yihan, Zhang, Sen, Dodd, Rory, Liu, Shuangying, Xu, Rongsong, Xu, Yongjin, Miret, Juan J, Rivera, Victor, Clackson, Tim, Shakespeare, William C, Zhu, Xiaotian, Dalgarno, David C

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The Gd3+ Complex of a Fatty Acid Analogue of DOTP Binds to Multiple Albumin Sites with Variable Water Relaxivities von Caravan, Peter, Greenfield, Matthew T, Li, Xiaodong, Sherry, A. Dean

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Enzyme-Activated Gd3+ Magnetic Resonance Imaging Contrast Agents with a Prominent Receptor-Induced Magnetization Enhancement von Nivorozhkin, Alexander L., Kolodziej, Andrew F., Caravan, Peter, Greenfield, Matthew T., Lauffer, Randall B., McMurry, Thomas J.

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Effect of Peptide-Chelate Architecture on Metabolic Stability of Peptide-based MRI Contrast Agents von Zhang, Zhaoda, Kolodziej, Andrew F, Qi, Jianfeng, Nair, Shrikumar A, Wang, Xifang, Case, April W, Greenfield, Matthew T, Graham, Philip B, McMurry, Thomas J, Caravan, Peter

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The Effect of the Amide Substituent on the Biodistribution and Tolerance of Lanthanide(III) DOTA-Tetraamide Derivatives von Woods, Mark, Caravan, Peter, Geraldes, Carlos F. G. C, Greenfield, Matthew T, Kiefer, Garry E, Lin, Mai, McMillan, Kenneth, Prata, M Isabel M, Santos, Ana C, Sun, Xiankai, Wang, Jufeng, Zhang, Shanrong, Zhao, Piyu, Sherry, A Dean

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When are Two Waters Worse Than One? Doubling the Hydration Number of a Gd-DTPA Derivative Decreases Relaxivity von Caravan, Peter, Amedio Jr, John C., Dunham, Stephen U., Greenfield, Matthew T., Cloutier, Normand J., McDermid, Sarah A., Spiller, Marga, Zech, Stephan G., Looby, Richard J., Raitsimring, Arnold M., McMurry, Thomas J., Lauffer, Randall B.

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207 Molecular MR-Imaging of myocardium using EP-3600, a collagen specific contrast agent: assessment of myocardial perfusion defects in a swine model von Spuentrup, Elmar, Ruhl, Karl M, Botnar, Rene M, Wiethoff, Andrea J, Buhl, Alexandra, Jacques, Vincent, Greenfield, Matthew T, Krombach, Gabriele A, Guenther, Rolf W, Caravan, Peter

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Heteroditopic Binding of Magnetic Resonance Contrast Agents for Increased Relaxivity von Zhang, Zhaoda, Kolodziej, Andrew F., Greenfield, Matthew T., Caravan, Peter

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Heteroditopic binding of MR contrast agents for increased relaxivity von Zhang, Zhaoda, Kolodziej, Andrew F., Greenfield, Matthew T., Caravan, Peter

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