Subclonal diversification of primary breast cancer revealed by multiregion sequencing von Yates, Lucy R, Gerstung, Moritz, Knappskog, Stian, Desmedt, Christine, Gundem, Gunes, Van Loo, Peter, Aas, Turid, Alexandrov, Ludmil B, Larsimont, Denis, Davies, Helen, Li, Yilong, Ju, Young Seok, Ramakrishna, Manasa, Haugland, Hans Kristian, Lilleng, Peer Kaare, Nik-Zainal, Serena, McLaren, Stuart, Butler, Adam, Martin, Sancha, Glodzik, Dominic, Menzies, Andrew, Raine, Keiran, Hinton, Jonathan, Jones, David, Mudie, Laura J, Jiang, Bing, Vincent, Delphine, Greene-Colozzi, April, Adnet, Pierre-Yves, Fatima, Aquila, Maetens, Marion, Ignatiadis, Michail, Stratton, Michael R, Sotiriou, Christos, Richardson, Andrea L, Lønning, Per Eystein, Wedge, David C, Campbell, Peter J

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Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer von Telli, Melinda L, Timms, Kirsten M, Reid, Julia, Hennessy, Bryan, Mills, Gordon B, Jensen, Kristin C, Szallasi, Zoltan, Barry, William T, Winer, Eric P, Tung, Nadine M, Isakoff, Steven J, Ryan, Paula D, Greene-Colozzi, April, Gutin, Alexander, Sangale, Zaina, Iliev, Diana, Neff, Chris, Abkevich, Victor, Jones, Joshua T, Lanchbury, Jerry S, Hartman, Anne-Renee, Garber, Judy E, Ford, James M, Silver, Daniel P, Richardson, Andrea L

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Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents von Birkbak, Nicolai J, Wang, Zhigang C, Kim, Ji-Young, Eklund, Aron C, Li, Qiyuan, Tian, Ruiyang, Bowman-Colin, Christian, Li, Yang, Greene-Colozzi, April, Iglehart, J Dirk, Tung, Nadine, Ryan, Paula D, Garber, Judy E, Silver, Daniel P, Szallasi, Zoltan, Richardson, Andrea L

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Stromal EGF and igf-I together modulate plasticity of disseminated triple-negative breast tumors von Castaño, Zafira, Marsh, Timothy, Tadipatri, Ramya, Kuznetsov, Hanna S, Al-Shahrour, Fatima, Paktinat, Mahnaz, Greene-Colozzi, April, Nilsson, Björn, Richardson, Andrea L, McAllister, Sandra S

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Identification of luminal breast cancers that establish a tumor-supportive macroenvironment defined by proangiogenic platelets and bone marrow-derived cells von Kuznetsov, Hanna S, Marsh, Timothy, Markens, Beth A, Castaño, Zafira, Greene-Colozzi, April, Hay, Samantha A, Brown, Victoria E, Richardson, Andrea L, Signoretti, Sabina, Battinelli, Elisabeth M, McAllister, Sandra S

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Abstract A112: Drug discovery efforts on the RNA protein methyltransferase METTL3/METTL14 von Boriack-Sjodin, P. Ann, Gardino, Alexandra K., Wynn, Thomas A., Buker, Shane M., Laidlaw, Monique, Sickmier, E. Allen, Hodous, Brian L., Case, April W., Greene-Colozzi, April E., Copeland, Robert A., Ribich, Scott

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Motion-Based Angiogenesis Analysis: A Simple Method to Quantify Blood Vessel Growth von Tong, Edmund Y., Collins, Geoffrey C., Greene-Colozzi, April E., Chen, Julia L., Manos, Philip D., Judkins, Kyle M., Lee, Joseph A., Ophir, Michael J., Laliberte, Farrah M., Levesque, Timothy J.

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Molecular Profiling of Human Mammary Gland Links Breast Cancer Risk to a p27+ Cell Population with Progenitor Characteristics von Choudhury, Sibgat, Almendro, Vanessa, Merino, Vanessa F., Wu, Zhenhua, Maruyama, Reo, Su, Ying, Martins, Filipe C., Fackler, Mary Jo, Bessarabova, Marina, Kowalczyk, Adam, Conway, Thomas, Beresford-Smith, Bryan, Macintyre, Geoff, Cheng, Yu-Kang, Lopez-Bujanda, Zoila, Kaspi, Antony, Hu, Rong, Robens, Judith, Nikolskaya, Tatiana, Haakensen, Vilde D., Schnitt, Stuart J., Argani, Pedram, Ethington, Gabrielle, Panos, Laura, Grant, Michael, Clark, Jason, Herlihy, William, Lin, S. Joyce, Chew, Grace, Thompson, Erik W., Greene-Colozzi, April, Richardson, Andrea L., Rosson, Gedge D., Pike, Malcolm, Garber, Judy E., Nikolsky, Yuri, Blum, Joanne L., Au, Alfred, Hwang, E. Shelley, Tamimi, Rulla M., Michor, Franziska, Haviv, Izhak, Liu, X. Shirley, Sukumar, Saraswati, Polyak, Kornelia

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Abstract A170: Discovery of small molecule inhibitors of ADAR1 von Buker, Shane M, Blakemore, Stephen J, Boriack-Sjodin, P. Ann, Collins, Cindy, Copeland, Robert A, Duncan, Kenneth W, Ericsson, Anna, Garadino, Alexandra, Greene-Colozzi, April, Leger, Nathalie, Lockbaum, Gordon, Raman, Anugraha, Ribich, Scott, Sickmier, Allen, Sparling, Brian S, Wu, Jie, Silver, Serena

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Optimisation and evaluation of a high-throughput mammalian protein expression system von Davies, Angela, Greene, April, Lullau, Elke, Abbott, W Mark

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Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancers von Telli, Melinda L., Timms, Kirsten M., Reid, Julia, Hennessy, Bryan, Mills, Gordon B., Jensen, Kristin C., Szallasi, Zoltan, Barry, William T., Winer, Eric P., Tung, Nadine M., Isakoff, Steven J., Ryan, Paula D., Greene-Colozzi, April, Gutin, Alexander, Sangale, Zaina, Iliev, Diana, Neff, Chris, Abkevich, Victor, Jones, Joshua T., Lanchbury, Jerry S., Hartman, Anne-Renee, Garber, Judy E., Ford, James M., Silver, Daniel P., Richardson, Andrea L.

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Total synthesis of a human leukocyte interferon gene von Edge, Michael D, Greene, April R, Heathcliffe, Gillian R, Meacock, Peter A, Schuch, Wolfgang, Scanlon, Denis B, Atkinson, Thomas C, Newton, Clive R, Markham, Alexander F

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Abstract P3-06-11: Homologous recombination deficiency (HRD) assay predicts response to cisplatin neoadjuvant chemotherapy in patients with triple negative breast cancer von Richardson, Andrea L, Silver, Daniel P, Szallasi, Zoltan, Birkbak, Nicolai J, Wang, Zhigang C, Iglehart, J Dirk, Mayer, Erica L, Winer, Eric P, Tung, Nadine M, Ryan, Paula D, Isakoff, Steven J, Barry, William T, Greene-Collozi, April, Gutin, Alexander, Reid, Julia, Neff, Chris, Jones, Joshua, Timms, Kirsten, Hartman, Anne-Renee, Garber, Judy E

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Abstract PR2: Identification of luminal breast cancers that establish a tumor supportive macroenvironment defined by proangiogenic platelets and bone marrow derived cells von Marsh, Timothy, Kuznetsov, Hanna, Markens, Beth, Castano, Zafira, Greene-Colozzi, April, Hay, Samantha, Brown, Victoria, Richardson, Andrea, Signoretti, Sabina, Battinelli, Elisabeth, McAllister, Sandra

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Abstract C94: Systemic and stromal support of triple-negative breast cancer progression is prevented by EGF and IGF-1 inhibitors von Castano, Zafira, Marsh, Tim, Tadipatri, Ramya, Kuznetsov, Hanna S., Al-Shahrour, Fatima, Paktinat, Mahanaz, Greene-Colozzi, April, Nilsson, Bjorn, Richardson, Andrea L., McAllister, Sandra S.

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Using the CRISPR/Cas9 System to Derive an Isogenic BRCA1 Mutant (187delAG) Strain From a Wild Type BRCA1 Mammary Epithelial Strain von Greene-Colozzi, April

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Subclonal diversification of primary breast cancer revealed by multiregion sequencing von Yates, Lucy R, Gerstung, Moritz, Knappskog, Stian, Desmedt, Christine, Gundem, Gunes, Loo, Peter Van, Aas, Turid, Alexandrov, Ludmil B, Larsimont, Denis, Davies, Helen, Li, Yilong, Ju, Young Seok, Ramakrishna, Manasa, Haugland, Hans Kristian, Lilleng, Peer Kaare, Nik-Zainal, Serena, McLaren, Stuart, Butler, Adam, Martin, Sancha, Glodzik, Dominic, Menzies, Andrew, Raine, Keiran, Hinton, Jonathan, Jones, David, Mudie, Laura J, Jiang, Bing, Vincent, Delphine, Greene-Colozzi, April, Adnet, Pierre-Yves, Fatima, Aquila, Maetens, Marion, Ignatiadis, Michail, Stratton, Michael R, Sotiriou, Christos, Richardson, Andrea L, Lønning, Per Eystein, Wedge, David C, Campbell, Peter J

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Stromal EGF and IGF1 Together Modulate Plasticity of Disseminated Triple Negative Breast Tumors von Castaño, Zafira, Marsh, Timothy, Tadipatri, Ramya, Kuznetsov, Hanna S., Al-Shahrour, Fatima, Paktinat, Mahnaz, Greene-Colozzi, April, Nilsson, Björn, Richardson, Andrea L., McAllister, Sandra S.

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Molecular Profiling of Human Mammary Gland Links Breast Cancer Risk to a p27 super(+) Cell Population with Progenitor Characteristics von Choudhury, Sibgat, Almendro, Vanessa, Merino, Vanessa F, Wu, Zhenhua, Maruyama, Reo, Su, Ying, Martins, Filipe C, Fackler, Mary Jo, Bessarabova, Marina, Kowalczyk, Adam, Conway, Thomas, Beresford-Smith, Bryan, Macintyre, Geoff, Cheng, Yu-Kang, Lopez-Bujanda, Zoila, Kaspi, Antony, Hu, Rong, Robens, Judith, Nikolskaya, Tatiana, Haakensen, Vilde D, Schnitt, Stuart J, Argani, Pedram, Ethington, Gabrielle, Panos, Laura, Grant, Michael, Clark, Jason, Herlihy, William, Lin, SJoyce, Chew, Grace, Thompson, Erik W, Greene-Colozzi, April, Richardson, Andrea L, Rosson, Gedge D, Pike, Malcolm, Garber, Judy E, Nikolsky, Yuri, Blum, Joanne L, Au, Alfred, Hwang, EShelley, Tamimi, Rulla M, Michor, Franziska, Haviv, Izhak, Liu, XShirley, Sukumar, Saraswati, Polyak, Kornelia

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Identification of Luminal Breast Cancers that Establish a Tumor Supportive Macroenvironment Defined by Pro-Angiogenic Platelets and Bone Marrow Derived Cells von Kuznetsov, Hanna S., Marsh, Timothy, Markens, Beth A., Castaño, Zafira, Greene-Colozzi, April, Hay, Samantha A., Brown, Victoria E., Richardson, Andrea L., Signoretti, Sabina, Battinelli, Elisabeth M., McAllister, Sandra S.

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