Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape von Noguchi, Takuro, Ward, Jeffrey P, Gubin, Matthew M, Arthur, Cora D, Lee, Sang Hun, Hundal, Jasreet, Selby, Mark J, Graziano, Robert F, Mardis, Elaine R, Korman, Alan J, Schreiber, Robert D

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The anti-SLAMF7 antibody elotuzumab mediates NK cell activation through both CD16-dependent and -independent mechanisms von Pazina, Tatiana, James, Ashley M., MacFarlane, Alexander W., Bezman, Natalie A., Henning, Karla A., Bee, Christine, Graziano, Robert F., Robbins, Michael D., Cohen, Adam D., Campbell, Kerry S.

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Development and Characterization of a Severe Acute Respiratory Syndrome—Associated Coronavirus—Neutralizing Human Monoclonal Antibody That Provides Effective Immunoprophylaxis in M... von Greenough, Thomas C., Babcock, Gregory J., Roberts, Anjeanette, Hernandez, Hector J., Thomas, William D., Coccia, Jennifer A., Graziano, Robert F., Srinivasan, Mohan, Lowy, Israel, Finberg, Robert W, Subbarao, Kanta, Vogel, Leatrice, Somasundaran, Mohan, Luzuriaga, Katherine, Sullivan, John L., Ambrosino, Donna M.

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PD-1 blockade enhances elotuzumab efficacy in mouse tumor models von Bezman, Natalie A., Jhatakia, Amy, Kearney, Alper Y., Brender, Ty, Maurer, Mark, Henning, Karla, Jenkins, Misty R., Rogers, Amy J., Neeson, Paul J., Korman, Alan J., Robbins, Michael D., Graziano, Robert F.

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In vitro and In vivo Characterization of MDX-1401 for Therapy of Malignant Lymphoma von CARDARELLI, Pina M, MOLDOVAN-LOOMIS, Maria-Cristina, ASSAD, Albert, WITTE, Alison, GRAZIANO, Robert F, KING, David J, PRESTON, Ben, BLACK, Amelia, PASSMORE, David, CHEN, Tseng-Hui, CHEN, Sharline, JIE LIU, KUHNE, Michelle R, SRINIVASAN, Mohan

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Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active Doses von Yang, Zheng, Rajendran, Surendran, Spires, Vanessa, Poirson, Brian, Gururajan, Murali, Lin, Zheng, Arbanas, Jaren, Krystek, Stanley, Loy, James, Cheng, Yuan, Carl, Stephen, Pace, Samantha, Wang, Yun, Mehl, John, Xu, Shihua, Vasudevan, Krishna, Broz, Miranda, Lehman-McKeeman, Lois, Morin, Paul, Graziano, Robert F.

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Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction von Huang, Richard Y-C, Krystek, Jr, Stanley R, Felix, Nathan, Graziano, Robert F, Srinivasan, Mohan, Pashine, Achal, Chen, Guodong

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Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy von Tu, Megan M, Lee, Francis Y F, Jones, Robert T, Kimball, Abigail K, Saravia, Elizabeth, Graziano, Robert F, Coleman, Brianne, Menard, Krista, Yan, Jun, Michaud, Erin, Chang, Han, Abdel-Hafiz, Hany A, Rozhok, Andrii I, Duex, Jason E, Agarwal, Neeraj, Chauca-Diaz, Ana, Johnson, Linda K, Ng, Terry L, Cambier, John C, Clambey, Eric T, Costello, James C, Korman, Alan J, Theodorescu, Dan

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Enhanced SLAMF7 Homotypic Interactions by Elotuzumab Improves NK Cell Killing of Multiple Myeloma von Pazina, Tatiana, James, Ashley M, Colby, Kimberly B, Yang, Yibin, Gale, Andrew, Jhatakia, Amy, Kearney, Alper Y, Graziano, Robert F, Bezman, Natalie A, Robbins, Michael D, Cohen, Adam D, Campbell, Kerry S

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Characterization of Mauritian Cynomolgus Macaque FcγR Alleles Using Long-Read Sequencing von Haj, Amelia K, Arbanas, Jaren M, Yamniuk, Aaron P, Karl, Julie A, Bussan, Hailey E, Drinkwater, Kenneth Y, Graham, Michael E, Ericsen, Adam J, Prall, Trent M, Moore, Kristina, Cheng, Lin, Gao, Mian, Graziano, Robert F, Loffredo, John T, Wiseman, Roger W, O'Connor, David H

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Activity and Safety of CTLA-4 Blockade Combined with Vaccines in Cynomolgus Macaques von Keler, Tibor, Halk, Ed, Vitale, Laura, O'Neill, Tom, Blanset, Diann, Lee, Steven, Srinivasan, Mohan, Graziano, Robert F, Davis, Thomas, Lonberg, Nils, Korman, Alan

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The human anti-CD30 antibody 5F11 shows in vitro and in vivo activity against malignant lymphoma von Borchmann, Peter, Treml, John F., Hansen, Hinrich, Gottstein, Claudia, Schnell, Roland, Staak, Oliver, Zhang, Hui-fen, Davis, Thomas, Keler, Tibor, Diehl, Volker, Graziano, Robert F., Engert, Andreas

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Humanized mAb H22 binds the human high affinity Fc receptor for IgG (FcgammaRI), blocks phagocytosis, and modulates receptor expression von Wallace, Paul K., Keler, Tibor, Coleman, Kimberly, Fisher, Jan, Vitale, Laura, Graziano, Robert F., Guyre, Paul M., Fanger, Michael W.

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Targeting Weak Antigens to CD64 Elicits Potent Humoral Responses in Human CD64 Transgenic Mice von Keler, Tibor, Guyre, Paul M, Vitale, Laura A, Sundarapandiyan, Karuna, van de Winkel, Jan G. J, Deo, Yashwant M, Graziano, Robert F

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Direct targeting of genetically modified tumour cells to FcγRI triggers potent tumour cytotoxicity von Bevaart, Lisette, Goldstein, Joel, Vitale, Laura, Russoniello, Christina, Treml, John, Zhang, Jun, Graziano, Robert F., Leusen, Jeanette H. W., Winkel, Jan G. J., Keler, Tibor

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Bispecific Molecules Directed to the Fc Receptor for IgA (Fc{alpha}RI, CD89) and Tumor Antigens Efficiently Promote Cell-Mediated Cytotoxicity of Tumor Targets in Whole Blood von Deo, Yashwant M, Sundarapandiyan, Karuna, Keler, Tibor, Wallace, Paul K, Graziano, Robert F

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Abstract IA10: Developing rational combination therapy with checkpoint inhibitors von Tu, Megan M., Lee, Francis Y. F., Jones, Robert T., Kimball, Abigail K., Saravia, Elizabeth, Graziano, Robert F., Coleman, Brianne, Menard, Krista, Yan, Jun, Michaud, Erin, Chang, Han, Abdel-Hafiz, Hany A., Rozhok, Andrii I., Duex, Jason E., Agarwal, Neeraj, Chauca-Diaz, Ana, Johnson, Linda K., Ng, Terry L., Cambier, John C., Clambey, Eric T., Costello, James C., Korman, Alan J., Theodorescu, Dan

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Abstract 2998: Elotuzumab can costimulate NK cell responses by engaging SLAMF7 von Pazina, Tatiana, James, Ashley Mentlik, MacFarlane, Alexander W., Bezman, Natalie A., Graziano, Robert F., Robbins, Michael D., Cohen, Adam D., Campbell, Kerry S.

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Abstract 4085: DDR2 inhibition enhances response to anti-PD-1 immunotherapy von Tu, Megan M., Lee, Francis Y., Jones, Robert T., Kimball, Abigail K., Saravia, Elizabeth, Graziano, Robert F., Coleman, Brianne, Menard, Krista, Yan, Jun, Michaud, Erin, Chang, Han, Abdel-Hafiz, Hany A., Rozhok, Andrii I., Duex, Jason E., Agarwal, Neeraj, Chauca-Diaz, Ana, Johnson, Linda K., Ng, Terry L., Cambier, John C., Clambey, Eric T., Costello, James C., Korman, Alan J., Theodorescu, Dan

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Enhanced Antigen-Specific Antibody and Cytokine Responses When Targeting Antigen to Human FcGAMMA Receptor Type I Using an Anti-Human FcGAMMA Receptor Type I-Streptavidin Fusion Pr... von Adamova, Elisaveta, Walsh, Mary C., Gosselin, Diane R., Hale, Karen, Preissler, Mark T., Graziano, Robert F., Gosselin, Edmund J.

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