The ins and outs of selective kinase inhibitor development von Müller, Susanne, Chaikuad, Apirat, Gray, Nathanael S, Knapp, Stefan

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Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation von Zhang, Tinghu, Hatcher, John M., Teng, Mingxing, Gray, Nathanael S., Kostic, Milka

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The Evolving War on Cancer von Haber, Daniel A., Gray, Nathanael S., Baselga, Jose

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Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency von Theunissen, Thorold W., Powell, Benjamin E., Wang, Haoyi, Mitalipova, Maya, Faddah, Dina A., Reddy, Jessica, Fan, Zi Peng, Maetzel, Dorothea, Ganz, Kibibi, Shi, Linyu, Lungjangwa, Tenzin, Imsoonthornruksa, Sumeth, Stelzer, Yonatan, Rangarajan, Sudharshan, D’Alessio, Ana, Zhang, Jianming, Gao, Qing, Dawlaty, Meelad M., Young, Richard A., Gray, Nathanael S., Jaenisch, Rudolf

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YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers von Galli, Giorgio G., Carrara, Matteo, Yuan, Wei-Chien, Valdes-Quezada, Christian, Gurung, Basanta, Pepe-Mooney, Brian, Zhang, Tinghu, Geeven, Geert, Gray, Nathanael S., de Laat, Wouter, Calogero, Raffaele A., Camargo, Fernando D.

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Plasticity in binding confers selectivity in ligand-induced protein degradation von Nowak, Radosław P., DeAngelo, Stephen L., Buckley, Dennis, He, Zhixiang, Donovan, Katherine A., An, Jian, Safaee, Nozhat, Jedrychowski, Mark P., Ponthier, Charles M., Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D., Gray, Nathanael S., Bradner, James E., Fischer, Eric S.

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EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors von Ercan, Dalia, Choi, Hwan Geun, Yun, Cai-Hong, Capelletti, Marzia, Xie, Ting, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A

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YY1 Is a Structural Regulator of Enhancer-Promoter Loops von Weintraub, Abraham S., Li, Charles H., Zamudio, Alicia V., Sigova, Alla A., Hannett, Nancy M., Day, Daniel S., Abraham, Brian J., Cohen, Malkiel A., Nabet, Behnam, Buckley, Dennis L., Guo, Yang Eric, Hnisz, Denes, Jaenisch, Rudolf, Bradner, James E., Gray, Nathanael S., Young, Richard A.

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Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery? von Zhao, Zheng, Wu, Hong, Wang, Li, Liu, Yi, Knapp, Stefan, Liu, Qingsong, Gray, Nathanael S

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Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 von Faust, Tyler B., Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., Fischer, Eric S.

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Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer von Dutt, Amit, Ramos, Alex H, Hammerman, Peter S, Mermel, Craig, Cho, Jeonghee, Sharifnia, Tanaz, Chande, Ajit, Tanaka, Kumiko Elisa, Stransky, Nicolas, Greulich, Heidi, Gray, Nathanael S, Meyerson, Matthew

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Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance von Zhou, Wen, Whiteley, Aaron T., de Oliveira Mann, Carina C., Morehouse, Benjamin R., Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Mekalanos, John J., Kranzusch, Philip J.

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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation von Olson, Calla M, Jiang, Baishan, Erb, Michael A, Liang, Yanke, Doctor, Zainab M, Zhang, Zinan, Zhang, Tinghu, Kwiatkowski, Nicholas, Boukhali, Myriam, Green, Jennifer L, Haas, Wilhelm, Nomanbhoy, Tyzoon, Fischer, Eric S, Young, Richard A, Bradner, James E, Winter, Georg E, Gray, Nathanael S

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Partitioning of cancer therapeutics in nuclear condensates von Klein, Isaac A, Boija, Ann, Afeyan, Lena K, Hawken, Susana Wilson, Fan, Mengyang, Dall'Agnese, Alessandra, Oksuz, Ozgur, Henninger, Jonathan E, Shrinivas, Krishna, Sabari, Benjamin R, Sagi, Ido, Clark, Victoria E, Platt, Jesse M, Kar, Mrityunjoy, McCall, Patrick M, Zamudio, Alicia V, Manteiga, John C, Coffey, Eliot L, Li, Charles H, Hannett, Nancy M, Guo, Yang Eric, Decker, Tim-Michael, Lee, Tong Ihn, Zhang, Tinghu, Weng, Jing-Ke, Taatjes, Dylan J, Chakraborty, Arup, Sharp, Phillip A, Chang, Young Tae, Hyman, Anthony A, Gray, Nathanael S, Young, Richard A

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Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML von Brand, Matthias, Jiang, Baishan, Bauer, Sophie, Donovan, Katherine A., Liang, Yanke, Wang, Eric S., Nowak, Radosław P., Yuan, Jingting C., Zhang, Tinghu, Kwiatkowski, Nicholas, Müller, André C., Fischer, Eric S., Gray, Nathanael S., Winter, Georg E.

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Prospects for Antibacterial Discovery and Development von Privalsky, Thomas M, Soohoo, Alexander M, Wang, Jinhua, Walsh, Christopher T, Wright, Gerard D, Gordon, Eric M, Gray, Nathanael S, Khosla, Chaitan

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Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules von Nabet, Behnam, Ferguson, Fleur M., Seong, Bo Kyung A., Kuljanin, Miljan, Leggett, Alan L., Mohardt, Mikaela L., Robichaud, Amanda, Conway, Amy S., Buckley, Dennis L., Mancias, Joseph D., Bradner, James E., Stegmaier, Kimberly, Gray, Nathanael S.

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A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation von Michel, Brittany C., D’Avino, Andrew R., Cassel, Seth H., Mashtalir, Nazar, McKenzie, Zachary M., McBride, Matthew J., Valencia, Alfredo M., Zhou, Qianhe, Bocker, Michael, Soares, Luis M. M., Pan, Joshua, Remillard, David I., Lareau, Caleb A., Zullow, Hayley J., Fortoul, Nora, Gray, Nathanael S., Bradner, James E., Chan, Ho Man, Kadoch, Cigall

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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader von Huang, Hai-Tsang, Dobrovolsky, Dennis, Paulk, Joshiawa, Yang, Guang, Weisberg, Ellen L., Doctor, Zainab M., Buckley, Dennis L., Cho, Joong-Heui, Ko, Eunhwa, Jang, Jaebong, Shi, Kun, Choi, Hwan Geun, Griffin, James D., Li, Ying, Treon, Steven P., Fischer, Eric S., Bradner, James E., Tan, Li, Gray, Nathanael S.

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BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment von Winter, Georg E., Mayer, Andreas, Buckley, Dennis L., Erb, Michael A., Roderick, Justine E., Vittori, Sarah, Reyes, Jaime M., di Iulio, Julia, Souza, Amanda, Ott, Christopher J., Roberts, Justin M., Zeid, Rhamy, Scott, Thomas G., Paulk, Joshiawa, Lachance, Kate, Olson, Calla M., Dastjerdi, Shiva, Bauer, Sophie, Lin, Charles Y., Gray, Nathanael S., Kelliher, Michelle A., Churchman, L. Stirling, Bradner, James E.

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