Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery von MacLean, Lorna M, Thomas, John, Lewis, Michael D, Cotillo, Ignacio, Gray, David W, De Rycker, Manu

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Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay von Svensen, Nina, Wyllie, Susan, Gray, David W, De Rycker, Manu

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Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade von De Rycker, Manu, Thomas, John, Riley, Jennifer, Brough, Stephen J, Miles, Tim J, Gray, David W

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New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource von Peña, Imanol, Pilar Manzano, M., Cantizani, Juan, Kessler, Albane, Alonso-Padilla, Julio, Bardera, Ana I., Alvarez, Emilio, Colmenarejo, Gonzalo, Cotillo, Ignacio, Roquero, Irene, de Dios-Anton, Francisco, Barroso, Vanessa, Rodriguez, Ana, Gray, David W., Navarro, Miguel, Kumar, Vinod, Sherstnev, Alexander, Drewry, David H., Brown, James R., Fiandor, Jose M., Julio Martin, J.

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Targeting N-myristoylation for therapy of B-cell lymphomas von Beauchamp, Erwan, Yap, Megan C., Iyer, Aishwarya, Perinpanayagam, Maneka A., Gamma, Jay M., Vincent, Krista M., Lakshmanan, Manikandan, Raju, Anandhkumar, Tergaonkar, Vinay, Tan, Soo Yong, Lim, Soon Thye, Dong, Wei-Feng, Postovit, Lynne M., Read, Kevin D., Gray, David W., Wyatt, Paul G., Mackey, John R., Berthiaume, Luc G.

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Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay von DE RYCKER, Manu, HALLYBURTON, Irene, FAIRLAMB, Alan H, GRAY, David W, THOMAS, John, CAMPBELL, Lorna, WYLLIE, Susan, JOSHI, Dhananjay, CAMERON, Scott, GILBERT, Ian H, WYATT, Paul G, FREARSON, Julie A

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Design of the Global Health chemical diversity library v2 for screening against infectious diseases von Wilson, Caroline, Gardner, J Mark F, Gray, David W, Baragana, Beatriz, Wyatt, Paul G, Cookson, Alex, Thompson, Stephen, Mendoza-Martinez, Cesar, Bodkin, Michael J, Gilbert, Ian H, Tarver, Gary J

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Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase von Torrie, Leah S, Zuccotto, Fabio, Robinson, David A, Gray, David W, Gilbert, Ian H, De Rycker, Manu

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Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity von Izquierdo, Maikel, Lin, De, O'Neill, Sandra, Webster, Lauren A, Paterson, Christy, Thomas, John, Aguado, Mirtha Elisa, Colina Araújo, Enrique, Alpízar-Pedraza, Daniel, Joji, Halimatu, MacLean, Lorna, Hope, Anthony, Gray, David W, Zoltner, Martin, Field, Mark C, González-Bacerio, Jorge, De Rycker, Manu

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HTS library plate rejuvenation using a DMSO-rich atmosphere von Hughes, Fraser, Cookson, Alex, Tamaki, Fabio, Bailey, Christopher, Gray, David W., Wrobel, Karolina, Cookson, Kirsty, Bell, Steve, Tarver, Gary

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Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intrac... von Nühs, Andrea, De Rycker, Manu, Manthri, Sujatha, Comer, Eamon, Scherer, Christina A, Schreiber, Stuart L, Ioset, Jean-Robert, Gray, David W

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Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease von Salter, Mark, Biggadike, Keith, Matthews, Joyce L, West, Michael R, Haase, Michael V, Farrow, Stuart N, Uings, Iain J, Gray, David W

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Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need von Field, Mark C., Horn, David, Fairlamb, Alan H., Ferguson, Michael A. J., Gray, David W., Read, Kevin D., De Rycker, Manu, Torrie, Leah S., Wyatt, Paul G., Wyllie, Susan, Gilbert, Ian H.

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A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes von De Rycker, Manu, O'Neill, Sandra, Joshi, Dhananjay, Campbell, Lorna, Gray, David W, Fairlamb, Alan H

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Structure–Activity Relationships of Pyrazolo[1,5‑a]pyrimidin-7(4H)‑ones as Antitubercular Agents von Oh, Sangmi, Libardo, M. Daben J, Azeeza, Shaik, Pauly, Gary T, Roma, Jose Santinni O, Sajid, Andaleeb, Tateishi, Yoshitaka, Duncombe, Caroline, Goodwin, Michael, Ioerger, Thomas R, Wyatt, Paul G, Ray, Peter C, Gray, David W, Boshoff, Helena I. M, Barry, Clifton E

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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition von Wyllie, Susan, Brand, Stephen, Thomas, Michael, De Rycker, Manu, Chung, Chun-wa, Pena, Imanol, Bingham, Ryan P., Bueren-Calabuig, Juan A., Cantizani, Juan, Cebrian, David, Craggs, Peter D., Ferguson, Liam, Goswami, Panchali, Hobrath, Judith, Howe, Jonathan, Jeacock, Laura, Ko, Eun-Jung, Korczynska, Justyna, MacLean, Lorna, Manthri, Sujatha, Martinez, Maria S., Mata-Cantero, Lydia, Moniz, Sonia, Nühs, Andrea, Osuna-Cabello, Maria, Pinto, Erika, Riley, Jennifer, Robinson, Sharon, Rowland, Paul, Simeons, Frederick R. C., Shishikura, Yoko, Spinks, Daniel, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Gaza, Elisabet Viayna, Wall, Richard J., Zuccotto, Fabio, Horn, David, Ferguson, Michael A. J., Fairlamb, Alan H., Fiandor, Jose M., Martin, Julio, Gray, David W., Miles, Timothy J., Gilbert, Ian H., Read, Kevin D., Marco, Maria, Wyatt, Paul G.

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Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis von Wyllie, Susan, Thomas, Michael, Patterson, Stephen, Crouch, Sabrinia, De Rycker, Manu, Lowe, Rhiannon, Gresham, Stephanie, Urbaniak, Michael D., Otto, Thomas D., Stojanovski, Laste, Simeons, Frederick R. C., Manthri, Sujatha, MacLean, Lorna M., Zuccotto, Fabio, Homeyer, Nadine, Pflaumer, Hannah, Boesche, Markus, Sastry, Lalitha, Connolly, Paul, Albrecht, Sebastian, Berriman, Matt, Drewes, Gerard, Gray, David W., Ghidelli-Disse, Sonja, Dixon, Susan, Fiandor, Jose M., Wyatt, Paul G., Ferguson, Michael A. J., Fairlamb, Alan H., Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.

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Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors von Eadsforth, Thomas C., Torrie, Leah S., Rowland, Paul, Edgar, Emma V., MacLean, Lorna M., Paterson, Christy, Robinson, David A., Shepherd, Sharon M., Thomas, John, Thomas, Michael G., Gray, David W., Postis, Vincent L.G., De Rycker, Manu

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Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay von Zmuda, Filip, Sastry, Lalitha, Shepherd, Sharon M, Jones, Deuan, Scott, Alison, Craggs, Peter D, Cortes, Alvaro, Gray, David W, Torrie, Leah S, De Rycker, Manu

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Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function von McBrinn, Rachel C., Fraser, Joanna, Hope, Anthony G., Gray, David W., Barratt, Christopher L.R., Martins da Silva, Sarah J., Brown, Sean G.

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