Orexins/Hypocretins and Cancer: A Neuropeptide as Emerging Target von Couvineau, Alain, Nicole, Pascal, Gratio, Valerie, Voisin, Thierry

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Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases von Couvineau, Alain, Voisin, Thierry, Nicole, Pascal, Gratio, Valérie, Abad, Catalina, Tan, Yossan-Var

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The Orexin-A/OX1R System Induces Cell Death in Pancreatic Cancer Cells Resistant to Gemcitabine and Nab-Paclitaxel Treatment von Voisin, Thierry, Nicole, Pascal, Gratio, Valérie, Chassac, Anaïs, Mansour, Dounia, Rebours, Vinciane, Couvelard, Anne, Couvineau, Alain

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Aberrant Expression and Activation of the Thrombin Receptor Protease-Activated Receptor-1 Induces Cell Proliferation and Motility in Human Colon Cancer Cells von Darmoul, Dalila, Gratio, Valérie, Devaud, Hélène, Lehy, Thérèse, Laburthe, Marc

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Kallikrein-Related Peptidase 4: A New Activator of the Aberrantly Expressed Protease-Activated Receptor 1 in Colon Cancer Cells von Gratio, Valerie, Beaufort, Nathalie, Seiz, Lina, Maier, Josefine, Virca, G. Duke, Debela, Mekdes, Grebenchtchikov, Nicolai, Magdolen, Viktor, Darmoul, Dalila

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The Orexin receptors: Structural and anti-tumoral properties von Couvineau, Alain, Nicole, Pascal, Gratio, Valérie, Voisin, Thierry

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hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism von Voisin, Thierry, El Firar, Aadil, Rouyer-Fessard, Christiane, Gratio, Valérie, Laburthe, Marc

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Orexins mitigate obesity‐associated dysfunctions in mice von Blais, Anne, Denis, Isabelle, Andriamihaja, Mireille, Gratio, Valérie, Champeil‐Potokar, Gaelle, Laouirem, Samira, Chassac, Anais, Couvelard, Anne, Paradis, Valérie, Voisin, Thierry, Davila, Anne‐Marie, Couvineau, Alain

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Identification of the Axis β-Catenin-BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment von Mihoub, Imane, Rharass, Tareck, Ouriemmi, Souhaïl, Oudar, Antonin, Aubard, Laure, Gratio, Valérie, Lazarian, Gregory, Ferreira, Jordan, Dondi, Elisabetta, Cymbalista, Florence, Levy, Vincent, Baran-Marszak, Fanny, Varin-Blank, Nadine, Ledoux, Dominique, Le Roy, Christine, Gardano, Laura

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Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions von Couvineau, Alain, Voisin, Thierry, Nicole, Pascal, Gratio, Valerie, Blais, Anne

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Activation of Proteinase-Activated Receptor 1 Promotes Human Colon Cancer Cell Proliferation Through Epidermal Growth Factor Receptor Transactivation von Darmoul, Dalila, Gratio, Valérie, Devaud, Hélène, Peiretti, Franck, Laburthe, Marc

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The Anti-tumoral Properties of Orexin/Hypocretin Hypothalamic Neuropeptides: An Unexpected Therapeutic Role von Couvineau, Alain, Dayot, Stéphanie, Nicole, Pascal, Gratio, Valérie, Rebours, Vinciane, Couvelard, Anne, Voisin, Thierry

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Kallikrein-Related Peptidase 14 Acts on Proteinase-Activated Receptor 2 to Induce Signaling Pathway in Colon Cancer Cells von Gratio, Valérie, Loriot, Céline, Virca, G. Duke, Oikonomopoulou, Katerina, Walker, Francine, Diamandis, Eleftherios P, Hollenberg, Morley D, Darmoul, Dalila

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Aberrant expression of proteinase‐activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB‐2 kinase von Gratio, Valérie, Walker, Francine, Lehy, Thérèse, Laburthe, Marc, Darmoul, Dalila

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Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors von Chung, Hyunjae, Hamza, Magda, Oikonomopoulou, Katerina, Gratio, Valérie, Saifeddine, Mahmoud, Virca, G. Duke, Diamandis, Eleftherios P., Hollenberg, Morley D., Darmoul, Dalila

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Abstract 4581: Combination treatment of orexin-A and NAB-paclitaxel in pancreas cancer: in vitro and in vivo studies von Voisin, Thierry, Plaut, Dina, Dayot, Stephanie, Bergere, Maxime, Gratio, Valerie, Nicole, Pascal, Couvelard, Anne, Couvineau, Alain

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Mo1684 Anti-Inflammatory Properties of the Neuropeptide Orexins in Ulcerative Colitis: A New Promising Therapeutical Molecule von Messal, Nassima, Fernandez, Neike, Bergere, Maxime, Pedruzzi, Eric, Gratio, Valerie, Nicole, Pascal, Treton, Xavier, Couvelard, Anne, Voisin, Thierry, Ogier-Denis, Eric, Couvineau, Alain

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PAR-2 activation increases human intestinal mucin secretion through EGFR transactivation von Jarry, Anne, Dorso, Laetitia, Gratio, Valérie, Forgue-Lafitte, Marie-Elisabeth, Laburthe, Marc, Laboisse, Christian L., Darmoul, Dalila

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Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation von Darmoul, Dalila, Gratio, Valérie, Devaud, Hélène, Laburthe, Marc

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In vitro , in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma von Dayot, Stéphanie, Speisky, Daniela, Couvelard, Anne, Bourgoin, Pierre, Gratio, Valérie, Cros, Jérôme, Rebours, Vinciane, Sauvanet, Alain, Bedossa, Pierre, Paradis, Valérie, Ruszniewski, Philippe, Couvineau, Alain, Voisin, Thierry

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