Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models von Chan-Penebre, Elayne, Armstrong, Kelli, Drew, Allison, Grassian, Alexandra R, Feldman, Igor, Knutson, Sarah K, Kuplast-Barr, Kristy, Roche, Maria, Campbell, John, Ho, Peter, Copeland, Robert A, Chesworth, Richard, Smith, Jesse J, Keilhack, Heike, Ribich, Scott A

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Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation von Grassian, Alexandra R, Metallo, Christian M, Coloff, Jonathan L, Stephanopoulos, Gregory, Brugge, Joan S

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IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism von GRASSIAN, Alexandra R, PARKER, Seth J, JOUD-CALDWELL, Carol, CHUNG, Franklin, HONG YIN, HANDLY, Erika D, STRAUB, Christopher, GROWNEY, Joseph D, HEIDEN, Matthew G. Vander, MURPHY, Anne N, PAGLIARINI, Raymond, METALLO, Christian M, DAVIDSON, Shawn M, DIVAKARUNI, Ajit S, GREEN, Courtney R, XIAMEI ZHANG, SLOCUM, Kelly L, MINYING PU, LIN, Fallon, VICKERS, Chad

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Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma von Kawano, Satoshi, Grassian, Alexandra R, Tsuda, Masumi, Knutson, Sarah K, Warholic, Natalie M, Kuznetsov, Galina, Xu, Shanqin, Xiao, Yonghong, Pollock, Roy M, Smith, Jesse S, Kuntz, Kevin K, Ribich, Scott, Minoshima, Yukinori, Matsui, Junji, Copeland, Robert A, Tanaka, Shinya, Keilhack, Heike

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Correction: Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma von Kawano, Satoshi, Grassian, Alexandra R, Tsuda, Masumi, Knutson, Sarah K, Warholic, Natalie M, Kuznetsov, Galina, Xu, Shanqin, Xiao, Yonghong, Pollock, Roy M, Smith, Jesse J, Kuntz, Kevin W, Ribich, Scott, Minoshima, Yukinori, Matsui, Junji, Copeland, Robert A, Tanaka, Shinya, Keilhack, Heike

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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment von Schafer, Zachary T., Grassian, Alexandra R., Song, Loling, Jiang, Zhenyang, Gerhart-Hines, Zachary, Irie, Hanna Y., Gao, Sizhen, Puigserver, Pere, Brugge, Joan S.

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis von Locasale, Jason W, Cantley, Lewis C, Vander Heiden, Matthew G, Grassian, Alexandra R, Melman, Tamar, Lyssiotis, Costas A, Mattaini, Katherine R, Bass, Adam J, Heffron, Gregory, Metallo, Christian M, Muranen, Taru, Sharfi, Hadar, Sasaki, Atsuo T, Anastasiou, Dimitrios, Mullarky, Edouard, Vokes, Natalie I, Sasaki, Mika, Beroukhim, Rameen, Stephanopoulos, Gregory, Ligon, Azra H, Meyerson, Matthew, Richardson, Andrea L, Chin, Lynda, Wagner, Gerhard, Asara, John M, Brugge, Joan S

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Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation von Thomenius, Michael J, Totman, Jennifer, Harvey, Darren, Mitchell, Lorna H, Riera, Thomas V, Cosmopoulos, Kat, Grassian, Alexandra R, Klaus, Christine, Foley, Megan, Admirand, Elizabeth A, Jahic, Haris, Majer, Christina, Wigle, Tim, Jacques, Suzanne L, Gureasko, Jodi, Brach, Dorothy, Lingaraj, Trupti, West, Kip, Smith, Sherri, Rioux, Nathalie, Waters, Nigel J, Tang, Cuyue, Raimondi, Alejandra, Munchhof, Michael, Mills, James E, Ribich, Scott, Porter Scott, Margaret, Kuntz, Kevin W, Janzen, William P, Moyer, Mikel, Smith, Jesse J, Chesworth, Richard, Copeland, Robert A, Boriack-Sjodin, P Ann

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Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT) von Grassian, Alexandra R., Lin, Fallon, Barrett, Rosemary, Liu, Yue, Jiang, Wei, Korpal, Manav, Astley, Holly, Gitterman, Daniel, Henley, Thomas, Howes, Rob, Levell, Julian, Korn, Joshua M., Pagliarini, Raymond

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Mutations of isocitrate dehydrogenase 1 and 2 in intrahepatic cholangiocarcinoma von Grassian, Alexandra R, Pagliarini, Raymond, Chiang, Derek Y

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ErbB2 Stabilizes Epidermal Growth Factor Receptor (EGFR) Expression via Erk and Sprouty2 in Extracellular Matrix-detached Cells von Grassian, Alexandra R., Schafer, Zachary T., Brugge, Joan S.

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CDK2 regulates collapsed replication fork repair in CCNE1-amplified ovarian cancer cells via homologous recombination von Brown, Victoria E, Moore, Sydney L, Chen, Maxine, House, Nealia, Ramsden, Philip, Wu, Hsin-Jung, Ribich, Scott, Grassian, Alexandra R, Choi, Yoon Jong

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Abstract 5159: Assessing the importance of the kinase domain through kinome-focused CRISPR screening von Kawam, Ahmad Al, Grassian, Alexandra R., Llambi, Fabien, Evans, Erica, Hoeflich, Klaus, Ye, Chaoyang

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Abstract 406: CRISPR pooled screening of hundreds of cancer cell lines identifies differential dependencies on epigenetic pathways and synthetic lethal relationships von Grassian, Alexandra R., Harvey, Darren, Fowler, Julian, Drew, Allison E., Feldman, Igor, Chesworth, Richard, Copeland, Robert, Smith, Jesse J., Ribich, Scott

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Abstract 3345: Selective killing of SMARCA2- and SMARCA4-deficient tumors by inhibition of EZH2: In vitro and in vivo preclinical models von Chan-Penebre, Elayne, Armstrong, Kelli, Drew, Allison, Grassian, Alexandra R., Feldman, Igor, Roche, Maria, Ho, Peter, Brach, Dorothy, Raimondi, Alejandra, Copeland, Robert A., Chesworth, Richard, Smith, Jesse J., Ribich, Scott A.

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Abstract B78: CRISPR pooled screening identifies differential dependencies on epigenetic pathways von Grassian, Alexandra R., Fowler, Julian, Feldman, Igor, Riera, Thomas, Harvey, Darren, Drew, Allison E., Chesworth, Richard, Copeland, Robert A., Keilhack, Heike, Smith, Jesse J., Ribich, Scott

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Abstract LB565: Efficacy of a highly potent and selective KIT V654A inhibitor for treatment of imatinib resistant GIST von Grassian, Alexandra R., Kim, Joseph, Ahmad, Omar, Barvian, Kevin, Davis, Alison, Dineen, Tom, Hu, Wei, Job, Ebby, Moine, Ludivine, Newberry, Kate, Roche, Maria, Shorten, Doug, Choi, Yeon Sook, Wolenski, Francis, Bauer, Sebastian, Serrano, Cesar, Trent, Jonathan, George, Suzanne

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Abstract C162: A medium-throughput single cell CRISPR-Cas9 assay to assess gene essentiality von Grassian, Alexandra R., Scales, Tim, Knutson, Sarah K., McCarthy, Nicola J., Lowe, Chris E., Moore, Jon D., Copeland, Robert A., Keilhack, Heike, Smith, Jesse J., Wickendon, Julie A., Ribich, Scott

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Abstract B159: Heterozygous IDH1 mutations modify the citric acid (TCA) cycle metabolism and sensitize cells to inhibition of mitochondrial respiration/oxidative phosphorylation von Grassian, Alexandra R., Parker, Seth, Davidson, Shawn, Green, Courtney, Lin, Fallon, Joud-Caldwell, Carol, Yin, Hong, Chung, Franklin, Straub, Christopher, Vander Heiden, Matthew, Pagliarini, Raymond, Metallo, Christian

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Abstract 2802: Evaluation of metabolic changes induced by loss of extracellular matrix attachment using 13C Flux analysis von Grassian, Alexandra R., Metallo, Christian M., Stephanopoulos, Gregory, Brugge, Joan S.

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