Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration von Liu, Lucy, Zhang, Ke, Sandoval, Hector, Yamamoto, Shinya, Jaiswal, Manish, Sanz, Elisenda, Li, Zhihong, Hui, Jessica, Graham, Brett H., Quintana, Albert, Bellen, Hugo J.

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Sox9 and NFIA Coordinate a Transcriptional Regulatory Cascade during the Initiation of Gliogenesis von Kang, Peng, Lee, Hyun Kyoung, Glasgow, Stacey M., Finley, Meggie, Donti, Tataka, Gaber, Zachary B., Graham, Brett H., Foster, Aaron E., Novitch, Bennett G., Gronostajski, Richard M., Deneen, Benjamin

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Succinyl-CoA Synthetase Dysfunction as a Mechanism of Mitochondrial Encephalomyopathy: More than Just an Oxidative Energy Deficit von Lancaster, Makayla S, Graham, Brett H

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Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys von Peng, Hui, Wang, Qianqian, Lou, Tanqi, Qin, Jun, Jung, Sungyun, Shetty, Vivekananda, Li, Feng, Wang, Yanlin, Feng, Xin-hua, Mitch, William E., Graham, Brett H., Hu, Zhaoyong

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Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer von Park, Jun Hyoung, Vithayathil, Sajna, Kumar, Santosh, Sung, Pi-Lin, Dobrolecki, Lacey Elizabeth, Putluri, Vasanta, Bhat, Vadiraja B., Bhowmik, Salil Kumar, Gupta, Vineet, Arora, Kavisha, Wu, Danli, Tsouko, Efrosini, Zhang, Yiqun, Maity, Suman, Donti, Taraka R., Graham, Brett H., Frigo, Daniel E., Coarfa, Cristian, Yotnda, Patricia, Putluri, Nagireddy, Sreekumar, Arun, Lewis, Michael T., Creighton, Chad J., Wong, Lee-Jun C., Kaipparettu, Benny Abraham

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Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans von Bayat, Vafa, Thiffault, Isabelle, Jaiswal, Manish, Tétreault, Martine, Donti, Taraka, Sasarman, Florin, Bernard, Geneviève, Demers-Lamarche, Julie, Dicaire, Marie-Josée, Mathieu, Jean, Vanasse, Michel, Bouchard, Jean-Pierre, Rioux, Marie-France, Lourenco, Charles M, Li, Zhihong, Haueter, Claire, Shoubridge, Eric A, Graham, Brett H, Brais, Bernard, Bellen, Hugo J

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Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress von Jaiswal, Manish, Haelterman, Nele A, Sandoval, Hector, Xiong, Bo, Donti, Taraka, Kalsotra, Auinash, Yamamoto, Shinya, Cooper, Thomas A, Graham, Brett H, Bellen, Hugo J

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Clinical course of sly syndrome (mucopolysaccharidosis type VII) von Montaño, Adriana M, Lock-Hock, Ngu, Steiner, Robert D, Graham, Brett H, Szlago, Marina, Greenstein, Robert, Pineda, Mercedes, Gonzalez-Meneses, Antonio, Çoker, Mahmut, Bartholomew, Dennis, Sands, Mark S, Wang, Raymond, Giugliani, Roberto, Macaya, Alfons, Pastores, Gregory, Ketko, Anastasia K, Ezgü, Fatih, Tanaka, Akemi, Arash, Laila, Beck, Michael, Falk, Rena E, Bhattacharya, Kaustuv, Franco, José, White, Klane K, Mitchell, Grant A, Cimbalistiene, Loreta, Holtz, Max, Sly, William S

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Mutations in FBXL4 Cause Mitochondrial Encephalopathy and a Disorder of Mitochondrial DNA Maintenance von Bonnen, Penelope E., Yarham, John W., Besse, Arnaud, Wu, Ping, Faqeih, Eissa A., Al-Asmari, Ali Mohammad, Saleh, Mohammad A.M., Eyaid, Wafaa, Hadeel, Alrukban, He, Langping, Smith, Frances, Yau, Shu, Simcox, Eve M., Miwa, Satomi, Donti, Taraka, Abu-Amero, Khaled K., Wong, Lee-Jun, Craigen, William J., Graham, Brett H., Scott, Kenneth L., McFarland, Robert, Taylor, Robert W.

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Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes von Harel, Tamar, Yoon, Wan Hee, Garone, Caterina, Gu, Shen, Coban-Akdemir, Zeynep, Eldomery, Mohammad K., Posey, Jennifer E., Jhangiani, Shalini N., Rosenfeld, Jill A., Cho, Megan T., Fox, Stephanie, Withers, Marjorie, Brooks, Stephanie M., Chiang, Theodore, Duraine, Lita, Erdin, Serkan, Yuan, Bo, Shao, Yunru, Moussallem, Elie, Lamperti, Costanza, Donati, Maria A., Smith, Joshua D., McLaughlin, Heather M., Eng, Christine M., Walkiewicz, Magdalena, Xia, Fan, Pippucci, Tommaso, Magini, Pamela, Seri, Marco, Zeviani, Massimo, Hirano, Michio, Hunter, Jill V., Srour, Myriam, Zanigni, Stefano, Lewis, Richard Alan, Muzny, Donna M., Lotze, Timothy E., Boerwinkle, Eric, Gibbs, Richard A., Hickey, Scott E., Graham, Brett H., Yang, Yaping, Buhas, Daniela, Martin, Donna M., Potocki, Lorraine, Graziano, Claudio, Bellen, Hugo J., Lupski, James R.

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Mutations in NGLY1 cause an inherited disorder of the endoplasmic reticulum–associated degradation pathway von Enns, Gregory M., Shashi, Vandana, Bainbridge, Matthew, Gambello, Michael J., Zahir, Farah R., Bast, Thomas, Crimian, Rebecca, Schoch, Kelly, Platt, Julia, Cox, Rachel, Bernstein, Jonathan A., Scavina, Mena, Walter, Rhonda S., Bibb, Audrey, Jones, Melanie, Hegde, Madhuri, Graham, Brett H., Need, Anna C., Oviedo, Angelica, Schaaf, Christian P., Boyle, Sean, Butte, Atul J., Chen, Rong, Clark, Michael J., Haraksingh, Rajini, Cowan, Tina M., He, Ping, Langlois, Sylvie, Zoghbi, Huda Y., Snyder, Michael, Gibbs, Richard A., Freeze, Hudson H., Goldstein, David B.

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Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse von Wangler, Michael F, Chao, Yu-Hsin, Bayat, Vafa, Giagtzoglou, Nikolaos, Shinde, Abhijit Babaji, Putluri, Nagireddy, Coarfa, Cristian, Donti, Taraka, Graham, Brett H, Faust, Joseph E, McNew, James A, Moser, Ann, Sardiello, Marco, Baes, Myriam, Bellen, Hugo J

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Elevations of C14:1 and C14:2 Plasma Acylcarnitines in Fasted Children: A Diagnostic Dilemma von Burrage, Lindsay C., MD, PhD, Miller, Marcus J., PhD, Wong, Lee-Jun, PhD, Kennedy, Adam D., PhD, Sutton, V. Reid, MD, Sun, Qin, PhD, Elsea, Sarah H., PhD, Graham, Brett H., MD, PhD

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The phenotypic spectrum of Schaaf-Yang syndrome: 18 new affected individuals from 14 families von Fountain, Michael D., Aten, Emmelien, Cho, Megan T., Juusola, Jane, Walkiewicz, Magdalena A., Ray, Joseph W., Xia, Fan, Yang, Yaping, Graham, Brett H., Bacino, Carlos A., Potocki, Lorraine, van Haeringen, Arie, Ruivenkamp, Claudia A.L., Mancias, Pedro, Northrup, Hope, Kukolich, Mary K., Weiss, Marjan M., van Ravenswaaij-Arts, Conny M.A., Mathijssen, Inge B., Levesque, Sebastien, Meeks, Naomi, Rosenfeld, Jill A., Lemke, Danielle, Hamosh, Ada, Lewis, Suzanne K., Race, Simone, Stewart, Laura L., Hay, Beverly, Lewis, Andrea M., Guerreiro, Rita L., Bras, Jose T., Martins, Marcia P., Derksen-Lubsen, Gerarda, Peeters, Els, Stumpel, Connie, Stegmann, Sander, Bok, Levinus A., Santen, Gijs W.E., Schaaf, Christian P.

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MED27 Variants Cause Developmental Delay, Dystonia, and Cerebellar Hypoplasia von Meng, Linyan, Isohanni, Pirjo, Shao, Yunru, Graham, Brett H., Hickey, Scott E., Brooks, Stephanie, Suomalainen, Anu, Joset, Pascal, Steindl, Katharina, Rauch, Anita, Hackenberg, Annette, High, Frances A., Armstrong‐Javors, Amy, Mencacci, Niccolò E., Gonzàlez‐Latapi, Paulina, Kamel, Walaa A., Al‐Hashel, Jasem Y., Bustos, Bernabé I., Hernandez, Alejandro V., Krainc, Dimitri, Lubbe, Steven J., Van Esch, Hilde, De Luca, Chiara, Ballon, Katleen, Ravelli, Claudia, Burglen, Lydie, Qebibo, Leila, Calame, Daniel G., Mitani, Tadahiro, Marafi, Dana, Pehlivan, Davut, Saadi, Nebal W., Sahin, Yavuz, Maroofian, Reza, Efthymiou, Stephanie, Houlden, Henry, Maqbool, Shazia, Rahman, Fatima, Gu, Shen, Posey, Jennifer E., Lupski, James R., Hunter, Jill V., Wangler, Michael F., Carroll, Christopher J., Yang, Yaping

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Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism von Lancaster, Makayla S., Kim, Byungwook, Doud, Emma H., Tate, Mason D., Sharify, Ahmad D., Gao, Hongyu, Chen, Duojiao, Simpson, Ed, Gillespie, Patrick, Chu, Xiaona, Miller, Marcus J., Wang, Yue, Liu, Yunlong, Mosley, Amber L., Kim, Jungsu, Graham, Brett H.

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Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production von Sandoval, Hector, Yao, Chi-Kuang, Chen, Kuchuan, Jaiswal, Manish, Donti, Taraka, Lin, Yong Qi, Bayat, Vafa, Xiong, Bo, Zhang, Ke, David, Gabriela, Charng, Wu-Lin, Yamamoto, Shinya, Duraine, Lita, Graham, Brett H, Bellen, Hugo J

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Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration von Chen, Kuchuan, Lin, Guang, Haelterman, Nele A, Ho, Tammy Szu-Yu, Li, Tongchao, Li, Zhihong, Duraine, Lita, Graham, Brett H, Jaiswal, Manish, Yamamoto, Shinya, Rasband, Matthew N, Bellen, Hugo J

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Mitochondrial Dysfunction Mediated by Poly(ADP-Ribose) Polymerase-1 Activation Contributes to Hippocampal Neuronal Damage Following Status Epilepticus von Lai, Yi-Chen, Baker, J Scott, Donti, Taraka, Graham, Brett H, Craigen, William J, Anderson, Anne E

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Untargeted Metabolomics of Slc13a5 Deficiency Reveal Critical Liver-Brain Axis for Lipid Homeostasis von Milosavljevic, Sofia, Glinton, Kevin E, Li, Xiqi, Medeiros, Cláudia, Gillespie, Patrick, Seavitt, John R, Graham, Brett H, Elsea, Sarah H

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