Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies von Knott, Maximilian M. L., Hölting, Tilman L. B., Ohmura, Shunya, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.

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Teacher-student collaborated multiple instance learning for pan-cancer PDL1 expression prediction from histopathology slides von Jin, Darui, Liang, Shangying, Shmatko, Artem, Arnold, Alexander, Horst, David, Grünewald, Thomas G. P., Gerstung, Moritz, Bai, Xiangzhi

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Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma von Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F., Li, Jing, Jabar, Susanne, Ranft, Andreas, Vinca, Endrit, Ceranski, Katharina, Carreno-Gonzalez, Martha J., Romero-Perez, Laura, Wehweck, Fabienne S., Musa, Julian, Bestvater, Felix, Knott, Maximilian M. L., Hoelting, Tilman L. B., Hartmann, Wolfgang, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grunewald, Thomas G. P.

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Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma von Kim, Yong Ryoul, Joo, Jaegeon, Lee, Hee Jung, Kim, Chaelim, Park, Ju-Chan, Yu, Young Suk, Kim, Chang Rok, Lee, Do Hui, Cha, Joowon, Kwon, Hyemin, Hanssen, Kimberley M., Grünewald, Thomas G. P., Choi, Murim, Han, Ilkyu, Bae, Sangsu, Jung, Inkyung, Shin, Yongdae, Baek, Sung Hee

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Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma von Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.

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A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas von Orth, Martin F., Buecklein, Veit Leonhard, Kampmann, Eric, Subklewe, Marion, Noessner, Elfriede, Cidre-Aranaz, Florencia, Romero-Pérez, Laura, Wehweck, Fabienne Sophie, Lindner, Lars, Issels, Rolf, Kirchner, Thomas, Altendorf-Hofmann, Annelore, Grünewald, Thomas G. P., Knösel, Thomas

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Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung von Martins, Leila R., Sieverling, Lina, Michelhans, Michelle, Schiller, Chiara, Erkut, Cihan, Grünewald, Thomas G. P., Triana, Sergio, Fröhling, Stefan, Velten, Lars, Glimm, Hanno, Scholl, Claudia

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Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer von Li, Jing, Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F., Imle, Roland, Dallmayer, Marlene, Musa, Julian, Knott, Maximilian M. L., Hölting, Tilman L. B., Stein, Stefanie, Funk, Cornelius M., Sastre, Ana, Alonso, Javier, Bestvater, Felix, Kasan, Merve, Romero-Pérez, Laura, Hartmann, Wolfgang, Ranft, Andreas, Banito, Ana, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.

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mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism von Levy, Tal, Voeltzke, Kai, Hruby, Laura, Alasad, Khawla, Bas, Zuelal, Snaebjörnsson, Marteinn, Marciano, Ran, Scharov, Katerina, Planque, Mélanie, Vriens, Kim, Christen, Stefan, Funk, Cornelius M., Hassiepen, Christina, Kahler, Alisa, Heider, Beate, Picard, Daniel, Lim, Jonathan K. M., Stefanski, Anja, Bendrin, Katja, Vargas-Toscano, Andres, Kahlert, Ulf D., Stühler, Kai, Remke, Marc, Elkabets, Moshe, Grünewald, Thomas G. P., Reichert, Andreas S., Fendt, Sarah-Maria, Schulze, Almut, Reifenberger, Guido, Rotblat, Barak, Leprivier, Gabriel

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Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship von Ceranski, A Katharina, Carreño-Gonzalez, Martha J, Ehlers, Anna C, Colombo, Maria Vittoria, Cidre-Aranaz, Florencia, Grünewald, Thomas G P

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Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells von Elia, Ilaria, Broekaert, Dorien, Christen, Stefan, Boon, Ruben, Radaelli, Enrico, Orth, Martin F., Verfaillie, Catherine, Grünewald, Thomas G. P., Fendt, Sarah-Maria

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Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma von Cidre-Aranaz, Florencia, Li, Jing, Hölting, Tilman L B, Orth, Martin F, Imle, Roland, Kutschmann, Stefanie, Ammirati, Giulia, Ceranski, Katharina, Carreño-Gonzalez, Martha Julia, Kasan, Merve, Marchetto, Aruna, Funk, Cornelius M, Bestvater, Felix, Bersini, Simone, Arrigoni, Chiara, Moretti, Matteo, Thiel, Uwe, Baumhoer, Daniel, Sahm, Felix, Pfister, Stefan M, Hartmann, Wolfgang, Dirksen, Uta, Romero-Pérez, Laura, Banito, Ana, Ohmura, Shunya, Musa, Julian, Kirchner, Thomas, Knott, Maximilian M L, Grünewald, Thomas G P

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Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma von Berthold, Ruth, Isfort, Ilka, Erkut, Cihan, Heinst, Lorena, Grünewald, Inga, Wardelmann, Eva, Kindler, Thomas, Åman, Pierre, Grünewald, Thomas G. P., Cidre-Aranaz, Florencia, Trautmann, Marcel, Fröhling, Stefan, Scholl, Claudia, Hartmann, Wolfgang

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Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota von Akagbosu, Blossom, Tayyebi, Zakieh, Shibu, Gayathri, Paucar Iza, Yoselin A., Deep, Deeksha, Parisotto, Yollanda Franco, Fisher, Logan, Pasolli, H. Amalia, Thevin, Valentin, Elmentaite, Rasa, Knott, Maximilian, Hemmers, Saskia, Jahn, Lorenz, Friedrich, Christin, Verter, Jacob, Wang, Zhong-Min, van den Brink, Marcel, Gasteiger, Georg, Grünewald, Thomas G. P., Marie, Julien C., Leslie, Christina, Rudensky, Alexander Y., Brown, Chrysothemis C.

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Ewing sarcoma von Grünewald, Thomas G. P., Cidre-Aranaz, Florencia, Surdez, Didier, Tomazou, Eleni M., de Álava, Enrique, Kovar, Heinrich, Sorensen, Poul H., Delattre, Olivier, Dirksen, Uta

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Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma von Hölting, Tilman L B, Cidre-Aranaz, Florencia, Matzek, Dana, Popper, Bastian, Jacobi, Severin J, Funk, Cornelius M, Geyer, Florian H, Li, Jing, Piseddu, Ignazio, Cadilha, Bruno L, Ledderose, Stephan, Zwilling, Jennifer, Ohmura, Shunya, Anz, David, Künkele, Annette, Klauschen, Frederick, Grünewald, Thomas G P, Knott, Maximilian M L

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Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours von Jones, David T. W., Banito, Ana, Grünewald, Thomas G. P., Haber, Michelle, Jäger, Natalie, Kool, Marcel, Milde, Till, Molenaar, Jan J., Nabbi, Arash, Pugh, Trevor J., Schleiermacher, Gudrun, Smith, Malcolm A., Westermann, Frank, Pfister, Stefan M.

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PHGDH heterogeneity potentiates cancer cell dissemination and metastasis von Rossi, Matteo, Altea-Manzano, Patricia, Demicco, Margherita, Doglioni, Ginevra, Bornes, Laura, Fukano, Marina, Vandekeere, Anke, Cuadros, Alejandro M., Fernández-García, Juan, Riera-Domingo, Carla, Jauset, Cristina, Planque, Mélanie, Alkan, H. Furkan, Nittner, David, Zuo, Dongmei, Broadfield, Lindsay A., Parik, Sweta, Pane, Antonino Alejandro, Rizzollo, Francesca, Rinaldi, Gianmarco, Zhang, Tao, Teoh, Shao Thing, Aurora, Arin B., Karras, Panagiotis, Vermeire, Ines, Broekaert, Dorien, Elsen, Joke Van, Knott, Maximilian M. L., Orth, Martin F., Demeyer, Sofie, Eelen, Guy, Dobrolecki, Lacey E., Bassez, Ayse, Brussel, Thomas Van, Sotlar, Karl, Lewis, Michael T., Bartsch, Harald, Wuhrer, Manfred, Veelen, Peter van, Carmeliet, Peter, Cools, Jan, Morrison, Sean J., Marine, Jean-Christophe, Lambrechts, Diether, Mazzone, Massimiliano, Hannon, Gregory J., Lunt, Sophia Y., Grünewald, Thomas G. P., Park, Morag, Rheenen, Jacco van, Fendt, Sarah-Maria

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Publisher Correction: Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma von Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.

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An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma von Shulman, David S., Whittle, Sarah B., Surdez, Didier, Bailey, Kelly M., de Álava, Enrique, Yustein, Jason T., Shlien, Adam, Hayashi, Masanori, Bishop, Alexander J. R., Crompton, Brian D., DuBois, Steven G., Shukla, Neerav, Leavey, Patrick J., Lessnick, Stephen L., Kovar, Heinrich, Delattre, Olivier, Grünewald, Thomas G. P., Antonescu, Cristina R., Roberts, Ryan D., Toretsky, Jeffrey A., Tirode, Franck, Gorlick, Richard, Janeway, Katherine A., Reed, Damon, Lawlor, Elizabeth R., Grohar, Patrick J.

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