Castration-Resistant Prostate Cancer: Locking Up the Molecular Escape Routes von ATTAR, Ricardo M, TAKIMOTO, Chris H, GOTTARDIS, Marco M

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Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes von NOVOSYADLYY, Ruslan, LANN, Danielle E, KURSHAN, Naamit, MEJIA, Wilson, SANTOPIETRO, Stefania, YAKAR, Shoshana, WOOD, Teresa L, LEROITH, Derek, VIJAYAKUMAR, Archana, ROWZEE, Anne, LAZZARINO, Deborah A, FIERZ, Yvonne, CARBONI, Joan M, GOTTARDIS, Marco M, PENNISI, Patricia A, MOLINOLO, Alfredo A

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BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR von Carboni, Joan M, Wittman, Mark, Yang, Zheng, Lee, Francis, Greer, Ann, Hurlburt, Warren, Hillerman, Stephen, Cao, Carolyn, Cantor, Glenn H, Dell-John, Janet, Chen, Cliff, Discenza, Lorell, Menard, Krista, Li, Aixin, Trainor, George, Vyas, Dolatrai, Kramer, Robert, Attar, Ricardo M, Gottardis, Marco M

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Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithe... von Kim, Hyun-Jung, Litzenburger, Beate C., Cui, Xiaojiang, Delgado, David A., Grabiner, Brian C., Lin, Xin, Lewis, Michael T., Gottardis, Marco M., Wong, Tai W., Attar, Ricardo M., Carboni, Joan M., Lee, Adrian V.

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Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2 von Purandare, A V, McDevitt, T M, Wan, H, You, D, Penhallow, B, Han, X, Vuppugalla, R, Zhang, Y, Ruepp, S U, Trainor, G L, Lombardo, L, Pedicord, D, Gottardis, M M, Ross-Macdonald, P, de Silva, H, Hosbach, J, Emanuel, S L, Blat, Y, Fitzpatrick, E, Taylor, T L, McIntyre, K W, Michaud, E, Mulligan, C, Lee, F Y, Woolfson, A, Lasho, T L, Pardanani, A, Tefferi, A, Lorenzi, M V

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Drug safety is a barrier to the discovery and development of new androgen receptor antagonists von Foster, William R., Car, Bruce D., Shi, Hong, Levesque, Paul C., Obermeier, Mary T., Gan, Jinping, Arezzo, Joseph C., Powlin, Stephanie S., Dinchuk, Joseph E., Balog, Aaron, Salvati, Mark E., Attar, Ricardo M., Gottardis, Marco M.

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HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924 von Haluska, Paul, Carboni, Joan M, TenEyck, Cynthia, Attar, Ricardo M, Hou, Xiaonan, Yu, Chunrong, Sagar, Malvika, Wong, Tai W, Gottardis, Marco M, Erlichman, Charles

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Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development von Wittman, Mark D, Carboni, Joan M, Yang, Zheng, Lee, Francis Y, Antman, Melissa, Attar, Ricardo, Balimane, Praveen, Chang, Chiehying, Chen, Cliff, Discenza, Lorell, Frennesson, David, Gottardis, Marco M, Greer, Ann, Hurlburt, Warren, Johnson, Walter, Langley, David R, Li, Aixin, Li, Jianqing, Liu, Peiying, Mastalerz, Harold, Mathur, Arvind, Menard, Krista, Patel, Karishma, Sack, John, Sang, Xiaopeng, Saulnier, Mark, Smith, Daniel, Stefanski, Kevin, Trainor, George, Velaparthi, Upender, Zhang, Guifen, Zimmermann, Kurt, Vyas, Dolatrai M

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Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathways von Dayyani, Farshid, Parikh, Nila U, Varkaris, Andreas S, Song, Jian H, Moorthy, Shhyam, Chatterji, Tanushree, Maity, Sankar N, Wolfe, Adam R, Carboni, Joan M, Gottardis, Marco M, Logothetis, Christopher J, Gallick, Gary E

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ETV6-NTRK3―Mediated Breast Epithelial Cell Transformation Is Blocked by Targeting the IGF1R Signaling Pathway von TOGNON, Cristina E, SOMASIRI, Aruna M, SORENSEN, Poul H. B, EVDOKIMOVA, Valentina E, TRIGO, Genny, UY, Evett E, MELNYK, Nataliya, CARBONI, Joan M, GOTTARDIS, Marco M, ROSKELLEY, Calvin D, POLLAK, Michael

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A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation von Tognon, C E, Martin, M J, Moradian, A, Trigo, G, Rotblat, B, Cheng, S-W G, Pollard, M, Uy, E, Chow, C, Carboni, J M, Gottardis, M M, Pollak, M, Morin, G B, Sorensen, P H B

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Molecular markers for novel therapies in neuroendocrine (carcinoid) tumors von Gilbert, Judith A, Adhikari, Laura J, Lloyd, Ricardo V, Rubin, Joseph, Haluska, Paul, Carboni, Joan M, Gottardis, Marco M, Ames, Matthew M

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Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor von CONNOR, Caroline E, NORRIS, John D, BROADWATER, Gloria, WILLSON, Timothy M, GOTTARDIS, Marco M, DEWHIRST, Mark W, MCDONNELL, Donald P

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Beyond tamoxifen : The retinoid X receptor-selective ligand LGD1069 (targretin) causes complete regression of mammary carcinoma von BISCHOFF, E. D, GOTTARDIS, M. M, MOON, T. E, HEYMAN, R. A, LAMPH, W. W

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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors von Richters, André, Doyle, Shelby K., Freeman, David B., Lee, Christina, Leifer, Becky S., Jagannathan, Sajjeev, Kabinger, Florian, Koren, Jošt Vrabič, Struntz, Nicholas B., Urgiles, Julie, Stagg, Ryan A., Curtin, Brice H., Chatterjee, Deep, Mathea, Sebastian, Mikochik, Peter J., Hopkins, Tamara D., Gao, Hua, Branch, Jonathan R., Xin, Hong, Westover, Lori, Bignan, Gilles C., Rupnow, Brent A., Karlin, Kristen L., Olson, Calla M., Westbrook, Thomas F., Vacca, Joseph, Wilfong, Chris M., Trotter, B. Wesley, Saffran, Douglas C., Bischofberger, Norbert, Knapp, Stefan, Russo, Joshua W., Hickson, Ian, Bischoff, James R., Gottardis, Marco M., Balk, Steven P., Lin, Charles Y., Pop, Marius S., Koehler, Angela N.

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Decreased Egr‐1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation von Huang, Ruo‐Pan, Fan, Yan, De Belle, Ian, Niemeyer, Christina, Gottardis, Marco M., Mercola, Dan, Adamson, Eileen D.

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Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells von Garcia-Morales, P, Saceda, M, Kenney, N, Kim, N, Salomon, D S, Gottardis, M M, Solomon, H B, Sholler, P F, Jordan, V C, Martin, M B

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BMS-536924 Reverses IGF-IR-Induced Transformation of Mammary Epithelial Cells and Causes Growth Inhibition and Polarization of MCF7 Cells von Litzenburger, Beate C, Kim, Hyun-Jung, Kuiatse, Isere, Carboni, Joan M, Attar, Ricardo M, Gottardis, Marco M, Fairchild, Craig R, Lee, Adrian V

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GREB1 is a novel androgen-regulated gene required for prostate cancer growth von Rae, James M., Johnson, Michael D., Cordero, Kevin E., Scheys, Joshua O., Larios, José M., Gottardis, Marco M., Pienta, Kenneth J., Lippman, Marc E.

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Chemoprevention of mammary carcinoma by LGD1069 (Targretin) : An RXR-selective ligand von GOTTARDIS, M. M, BISCHOFF, E. D, SHIRLEY, M. A, WAGONER, M. A, LAMPH, W. W, HEYMAN, R. A

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