Caspase-1 As a Therapeutic Target in Intravascular Hemolysis-Induced Microvascular Inflammation and Occlusive Processes von Brito, Pamela L, Gotardo, Erica M.F., Gushiken, Lucas F.S., Leonardo, Flavia C., Costa, Fernando Ferreira, Conran, Nicola

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Neutralization of IL-1β and P-Selectin Inhibition Attenuate Organ Injury in Mice with Sickle Cell Disease von Gotardo, Erica M.F., Gushiken, Lucas F.S., Brito, Pamela L, Leonardo, Flavia C., Torres, Lidiane S., Agoulnik, Sergei, Kovarik, Jiri, Bruederle, Andreas, Millholland, John, Costa, Fernando Ferreira, Conran, Nicola

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Anti-Inflammatory Effects of Hydroxyurea in a Murine Model of Chronic Intravascular Hemolysis von Gotardo, Erica M.F., Brito, Pamela L., Chweih, Hanan, Leonardo, Flavia C., Costa, Fernando Ferreira, Conran, Nicola

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Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition von Brito, Pamela L, Dos Santos, Alisson F, Chweih, Hanan, Favero, Maria E, Gotardo, Erica M F, Silva, Juliete A F, Leonardo, Flavia C, Franco-Penteado, Carla F, de Oliveira, Mariana G, Ferreira, Jr, Wilson A, Zaidan, Bruna C, Billis, Athanase, Baldanzi, Giorgio, Mashima, Denise A, Antunes, Edson, Saad, Sara T Olalla, Costa, Fernando F, Conran, Nicola

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Neutralization of Inflammasome-Processed Cytokines Reduces Inflammatory Mechanisms and Leukocyte Recruitment in the Vasculature of TNF-α-Stimulated Sickle Cell Disease Mice von Torres, Lidiane S., Gotardo, Erica M.F., Leonardo, Flávia Costa, Brito, Pamela L., Förster, Irmgard, Kovarik, Jiri, Costa, Fernando Ferreira, Conran, Nicola

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P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion von Gotardo, Erica M.F., Torres, Lidiane S., Gushiken, Lucas F.S., Brito, Pamela L., Leonardo, Flavia C., Agoulnik, Sergei, Kovarik, Jiri, Bruederle, Andreas, Millholland, John, Vitaliti, Alessandra, Förster, Irmgard, Costa, Fernando Ferreira, Conran, Nicola

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Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo von Gotardo, Erica M.F., Chweih, Hanan, Brito, Pamela L., Leonardo, Flavia C., Costa, Raquel, Soares, Raquel, Costa, Fernando F., Conran, Nicola

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Glomerular Hypertrophy and Alterations in Renin-Angiotensin System Activation Are Associated with Diminished Systemic Blood Pressure in Aging Mice with Sickle Cell Anemia von Brito, Pamela L., Gotardo, Erica M.F., Chweih, Hanan, Ferreira, Wilson A., Leonardo, Flavia C., Franco-Penteado, Carla F., Oliveira, Mariana Gonçalves, Antunes, Edson, Costa, Fernando F., Conran, Nicola

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The Ribonucleotide Reductase Inhibitor, Didox, Reduces the In Vivo Vascular Inflammation and Oxidative Stress Induced By Acute Hemolysis von Conran, Nicola, Silva, Juliete A.F., Gotardo, Erica M.F., Chweih, Hanan, Miguel, Lediana I., Leonardo, Flávia Costa, Ferreira, Wilson A., Hedlund, Bo E., Elford, Howard L., Costa, Fernando F.

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Effects of yerba maté, a plant extract formulation ("YGD") and resveratrol in 3T3-L1 adipogenesis von Santos, Juliana C, Gotardo, Erica M F, Brianti, Mitsue T, Piraee, Mahmood, Gambero, Alessandra, Ribeiro, Marcelo L

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TGF-β1 Reduces Neutrophil Adhesion and Prevents Acute Vaso-Occlusive Processes in Sickle Cell Disease Mice von Torres, Lidiane S, Chweih, Hanan, Fabris, Fernanda C Z, Gotardo, Erica M F, Leonardo, Flávia C, Saad, Sara T Olalla, Costa, Fernando F, Conran, Nicola

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Role for Platelets in Mediating Neutrophil Recruitment in TNF-α Induced Vaso-Occlusive Processes in Animals with Sickle Cell Anemia von Chweih, Hanan, Silva, Juliete A.F., Ferreira, Wilson A., Brito, Pamela L., Gotardo, Erica M.F., Leonardo, Flavia C., Franco-Penteado, Carla F, Costa, Fernando Ferreira, Conran, Nicola

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Combined Treatment with Hydroxyurea and a Phosphodiesterase 9 (PDE9) Inhibitor Decreases Hepatic Damage in an Animal Model of Sickle Cell Anemia von Silva, Juliete A.F., Chweih, Hanan, Gotardo, Erica M.F., Ferreira, Wilson A., Franco-Penteado, Carla F., Almeida, Camila B., Costa, Fernando F., Conran, Nicola

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TNF-Induced Vaso-Occlusive and Inflammatory Processes in Mice with Sickle Cell Anemia Are Abrogated By the Platelet Activation Inhibitor, Prasugrel von Chweih, Hanan, Silva, Juliete A.F., Gotardo, Erica M.F., Brito, Pamela L., Barbosa, Guilherme G.O., Garcia, Flavia, Ferreira, Wilson A., Leonardo, Flavia C., Franco-Penteado, Carla F., Costa, Fernando F., Conran, Nicola

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Heme induces significant neutrophil adhesion in vitro via an NFκB and reactive oxygen species-dependent pathway von Miguel, Lediana I., Leonardo, Flávia C., Torres, Lidiane S., Garcia, Flávia, Mendonça, Rafaela, Ferreira, Wilson A., Gotardo, Érica M. F., Fabris, Fernanda C. Z., Brito, Pamela L., Costa, Fernando F., Conran, Nicola

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Molecular and cellular effects of in vivo chronic intravascular hemolysis and anti-inflammatory therapeutic approaches von Gotardo, Érica M.F., Brito, Pamela L., Gushiken, Lucas F.S., Chweih, Hanan, Leonardo, Flavia C., Costa, Fernando F., Conran, Nicola

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Didox (3,4-dihydroxybenzohydroxamic acid) reduces the vascular inflammation induced by acute intravascular hemolysis von Silva, Juliete A.F., Gotardo, Érica M.F., Chweih, Hanan, Miguel, Lediana I., Ferreira, Wilson A., Hedlund, Bo, Elford, Howard L., Leonardo, Flavia C., Costa, Fernando F., Conran, Nicola

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