Hypermutation in human cancer genomes: footprints and mechanisms von Roberts, Steven A., Gordenin, Dmitry A.

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Clusters of Multiple Mutations: Incidence and Molecular Mechanisms von Chan, Kin, Gordenin, Dmitry A

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Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions von Roberts, Steven A., Sterling, Joan, Thompson, Cole, Harris, Shawn, Mav, Deepak, Shah, Ruchir, Klimczak, Leszek J., Kryukov, Gregory V., Malc, Ewa, Mieczkowski, Piotr A., Resnick, Michael A., Gordenin, Dmitry A.

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An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers von Chan, Kin, Roberts, Steven A, Klimczak, Leszek J, Sterling, Joan F, Saini, Natalie, Malc, Ewa P, Kim, Jaegil, Kwiatkowski, David J, Fargo, David C, Mieczkowski, Piotr A, Getz, Gad, Gordenin, Dmitry A

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Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic von Klimczak, Leszek J., Randall, Thomas A., Saini, Natalie, Li, Jian-Liang, Gordenin, Dmitry A.

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Break-Induced Replication Is a Source of Mutation Clusters Underlying Kataegis von Sakofsky, Cynthia J., Roberts, Steven A., Malc, Ewa, Mieczkowski, Piotr A., Resnick, Michael A., Gordenin, Dmitry A., Malkova, Anna

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Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies von Perelygina, Ludmila, Chen, Min-Hsin, Suppiah, Suganthi, Adebayo, Adebola, Abernathy, Emily, Dorsey, Morna, Bercovitch, Lionel, Paris, Kenneth, White, Kevin P, Krol, Alfons, Dhossche, Julie, Torshin, Ivan Y, Saini, Natalie, Klimczak, Leszek J, Gordenin, Dmitry A, Zharkikh, Andrey, Plotkin, Stanley, Sullivan, Kathleen E, Icenogle, Joseph

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Copy number signature analysis tool and its application in prostate cancer reveals distinct mutational processes and clinical outcomes von Wang, Shixiang, Li, Huimin, Song, Minfang, Tao, Ziyu, Wu, Tao, He, Zaoke, Zhao, Xiangyu, Wu, Kai, Liu, Xue-Song

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Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature von Degtyareva, Natalya P, Saini, Natalie, Sterling, Joan F, Placentra, Victoria C, Klimczak, Leszek J, Gordenin, Dmitry A, Doetsch, Paul W

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Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation von Sakofsky, Cynthia J, Saini, Natalie, Klimczak, Leszek J, Chan, Kin, Malc, Ewa P, Mieczkowski, Piotr A, Burkholder, Adam B, Fargo, David, Gordenin, Dmitry A

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Division of Labor at the Eukaryotic Replication Fork von Nick McElhinny, Stephanie A., Gordenin, Dmitry A., Stith, Carrie M., Burgers, Peter M.J., Kunkel, Thomas A.

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TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage von Gianini, Marta, Bayona-Feliu, Aleix, Sproviero, Daisy, Barroso, Sonia I., Cereda, Cristina, Aguilera, Andres

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ARID1A regulates R-loop associated DNA replication stress von Tsai, Shuhe, Fournier, Louis-Alexandre, Chang, Emily Yun-chia, Wells, James P., Minaker, Sean W., Zhu, Yi Dan, Wang, Alan Ying-Hsu, Wang, Yemin, Huntsman, David G., Stirling, Peter C.

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Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition von Lujan, Scott A, Clausen, Anders R, Clark, Alan B, MacAlpine, Heather K, MacAlpine, David M, Malc, Ewa P, Mieczkowski, Piotr A, Burkholder, Adam B, Fargo, David C, Gordenin, Dmitry A, Kunkel, Thomas A

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The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts von Saini, Natalie, Roberts, Steven A, Klimczak, Leszek J, Chan, Kin, Grimm, Sara A, Dai, Shuangshuang, Fargo, David C, Boyer, Jayne C, Kaufmann, William K, Taylor, Jack A, Lee, Eunjung, Cortes-Ciriano, Isidro, Park, Peter J, Schurman, Shepherd H, Malc, Ewa P, Mieczkowski, Piotr A, Gordenin, Dmitry A

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UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin von Saini, Natalie, Giacobone, Camille K., Klimczak, Leszek J., Papas, Brian N., Burkholder, Adam B., Li, Jian-Liang, Fargo, David C., Bai, Re, Gerrish, Kevin, Innes, Cynthia L., Schurman, Shepherd H., Gordenin, Dmitry A.

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Acetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and Cancer von Gong, Fade, Chiu, Li-Ya, Miller, Kyle M

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Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae von Yang, Yong, Sterling, Joan, Storici, Francesca, Resnick, Michael A, Gordenin, Dmitry A

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Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers von Elliott, Kerryn, Boström, Martin, Filges, Stefan, Lindberg, Markus, Van den Eynden, Jimmy, Ståhlberg, Anders, Clausen, Anders R, Larsson, Erik

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From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution von Kockler, Zachary W., Gordenin, Dmitry A.

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