Mechanisms of emphysema in alpha1-antitrypsin deficiency: molecular and cellular insights von Gooptu, B, Ekeowa, U I, Lomas, D A

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P117 3D cryo-electron microscopic analysis of the disease mechanism of  1-antitrypsin deficiency von Gooptu, B., Chaban, Y., Irving, J. A., Clare, D. K., Lomas, D. A., Orlova, E., Saibil, H. R.

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S62 Characterisation of a novel "pseudo-Z" variant of  1-antitrypsin von Nyon, M.-P., Segu, L., Roussel, B., Kalsheker, N., Lomas, D. A., Thalassinos, K., Gooptu, B.

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Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis von Calver, J, Parmar, N, Harris, G, Lithgo, R, Stylianou, P, Zetterberg, F, Gooptu, B, Mackinnon, A, Carr, S, Borthwick, L, Scott, D, Stewart, I, Slack, R, Jenkins, G, John, A

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Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders von Gordon, Patrick, Gooptu, Bibek

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S89 Ex vivo studies of the gal-3-fibrosome hypothesis in IPF and non-fibrotic control lung tissue and myofibroblasts von Miah, A, Stylianou, P, Tongue, P, Roach, K, Bradding, P, Gooptu, B

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S63 Use of NMR spectroscopy and nanospray mass spectrometry to characterise binding of lead compounds for drug design in  1-antitrypsin deficiency von Nyon, M.-P., Levy, G., Kirkpatrick, J., Ekeowa, U., Lomas, D. A., Cabrita, L. D., Christodoulou, J., McKay, A., Gooptu, B.

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Oxygen alert cards and controlled oxygen: preventing emergency admissions at risk of hypercapnic acidosis receiving high inspired oxygen concentrations in ambulances and A&E depart... von Gooptu, B, Ward, L, Ansari, S O, Eraut, C D, Law, D, Davison, A G

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S83 Pigeon fanciers with normal spirometry and no known ILD, display forced oscillometry findings suggestive of sub-clinical interstitial lung disease von Spears, M, Henderson, W, Dickson, S, Johnson, E, Bourke, SJ, Gooptu, B, Allen, R, Wain, LV, McSharry, C

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C13 TRANSLATIONAL RESEARCH IN ASTHMA: Vitamin D Modulation Of α1-Antitrypsin In Human Airways And T Lymphocytes von Hawrylowicz, C M, Chen, H, Rice, L, Dimeloe, S, Gupta, A, Kemper, C, Gooptu, B

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P136 Relationship between progression of lung disease in alpha-1 antitrypsin deficiency and cardiovascular risk von Hall, C, Samanta, S, Verma, N, Gooptu, B, Hurst, JR

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S85 Analysis of blood cell counts as predictors of survival in patients with hypersensitivity pneumonitis versus idiopathic pulmonary fibrosis in a multicentre retrospective cohort... von Barratt, SL, Adamali, H, Creamer, A, Duckworth, A, Wollerton, R, Fallon, J, Gibbons, MA, Gooptu, B, Fidan, S, Nancarrow, T, Pepperell, J, Stone, RA, Woodhead, FA, Scotton, CJ

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Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare dise... von Crossley, D, Stockley, J, Bolton, CE, Hopkinson, NS, Mahadeva, R, Steiner, M, Wilkinson, T, Hurst, JR, Gooptu, B, Stockley, RA

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P59 Utility Of Fib4 Score And Liver Disease In Alpha-1 Antitrypsin Deficiency (a1atd) von Bruce-Hickman, D., Saleh, A., Gooptu, B., Lomas, D., Thorburn, D., Hurst, J.

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S97 Severity of lung but not liver disease impacts cardiovascular risk in alpha-1 antitrypsin deficiency: Abstract S97 Table 1 von Samanta, S, Saleh, AD, Gooptu, B, Marshall, A, Thorburn, D, Lomas, DA, Hurst, JR

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S97 Severity of lung but not liver disease impacts cardiovascular risk in alpha-1 antitrypsin deficiency von Samanta, S, Saleh, AD, Gooptu, B, Marshall, A, Thorburn, D, Lomas, DA, Hurst, JR

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Conformational changes and disease — serpins, prions and Alzheimer's von Carrell, Robin W, Gooptu, Bibek

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D27 MITOCHONDRIA: LIVE AND LET DIE: Subcellular Responses To Misfolding In Er Stress And [alpha]1-Antitrypsin Deficiency von Gooptu, B, Nyon, M, Cryar, A, Segeritz, C, Smith, G, Ordonez, A, Dickens, J A, Lomas, D, Jones, A, Marciniak, S J, Thalassinos, K

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P121 Cost-Effectiveness of Alpha-1 Antitrypsin (A1AT) Deficiency Case-Finding in Secondary Care von Dron, L, Whiting, S, Thorburn, D, Pinzani, M, Gooptu, B, Lomas, DA, Hurst, JR

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P121 Cost-Effectiveness of Alpha-1 Antitrypsin (A1AT) Deficiency Case-Finding in Secondary Care: Abstract P121 TABLE 1 von Dron, L, Whiting, S, Thorburn, D, Pinzani, M, Gooptu, B, Lomas, DA, Hurst, JR

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