Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19 von Khoo, Weng Hua, Jackson, Katherine, Phetsouphanh, Chansavath, Zaunders, John J., Alquicira-Hernandez, José, Yazar, Seyhan, Ruiz-Diaz, Stephanie, Singh, Mandeep, Dhenni, Rama, Kyaw, Wunna, Tea, Fiona, Merheb, Vera, Lee, Fiona X.Z., Burrell, Rebecca, Howard-Jones, Annaleise, Koirala, Archana, Zhou, Li, Yuksel, Aysen, Catchpoole, Daniel R., Lai, Catherine L., Vitagliano, Tennille L., Rouet, Romain, Christ, Daniel, Tang, Benjamin, West, Nicholas P., George, Shane, Gerrard, John, Croucher, Peter I., Kelleher, Anthony D., Goodnow, Christopher G., Sprent, Jonathan D., Powell, Joseph E., Brilot, Fabienne, Nanan, Ralph, Hsu, Peter S., Deenick, Elissa K., Britton, Philip N., Phan, Tri Giang

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Clonal dynamics of SARS-CoV-2-specific T cells in children and adults with COVID-19 von Khoo, Weng Hua, Jackson, Katherine, Phetsouphanh, Chansavath, Zaunders, John J, Alquicira-Hernandez, José, Yazar, Seyhan, Ruiz-Diaz, Stephanie, Singh, Mandeep, Dhenni, Rama, Kyaw, Wunna, Tea, Fiona, Merheb, Vera, Lee, Fiona X. Z, Burrell, Rebecca, Howard-Jones, Annaleise, Koirala, Archana, Zhou, Li, Yuksel, Aysen, Catchpoole, Daniel R, Lai, Catherine L, Vitagliano, Tennille L, Rouet, Romain, Christ, Daniel, Tang, Benjamin, West, Nicholas P, George, Shane, Gerrard, John, Croucher, Peter I, Kelleher, Anthony D, Goodnow, Christopher G, Sprent, Jonathan D, Powell, Joseph D, Brilot, Fabienne, Nanan, Ralph, Hsu, Peter S, Deenick, Elissa K, Britton, Philip N, Phan, Tri Giang

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Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation von Pratama, Alvin, Ramiscal, Roybel R., Silva, Diego G., Das, Souvik K., Athanasopoulos, Vicki, Fitch, Jessica, Botelho, Natalia K., Chang, Pheh-Ping, Hu, Xin, Hogan, Jennifer J., Maña, Paula, Bernal, David, Korner, Heinrich, Yu, Di, Goodnow, Christopher C., Cook, Matthew C., Vinuesa, Carola G.

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Cellular and genetic mechanisms of self tolerance and autoimmunity von Goodnow, Christopher C, Sprent, Jonathon, de St Groth, Barbara Fazekas, Vinuesa, Carola G

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Two levels of protection for the B cell genome during somatic hypermutation von Schatz, David G, Liu, Man, Duke, Jamie L, Richter, Daniel J, Vinuesa, Carola G, Goodnow, Christopher C, Kleinstein, Steven H

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Control systems and decision making for antibody production von Goodnow, Christopher C, Mackay, Fabienne, Brink, Robert, Randall, Katrina L, Vinuesa, Carola G

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DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns von Skvortsova, Ksenia, Masle-Farquhar, Etienne, Luu, Phuc-Loi, Song, Jenny Z., Qu, Wenjia, Zotenko, Elena, Gould, Cathryn M., Du, Qian, Peters, Timothy J., Colino-Sanguino, Yolanda, Pidsley, Ruth, Nair, Shalima S., Khoury, Amanda, Smith, Grady C., Miosge, Lisa A., Reed, Joanne H., Kench, James G., Rubin, Mark A., Horvath, Lisa, Bogdanovic, Ozren, Lim, Sue Mei, Polo, Jose M., Goodnow, Christopher C., Stirzaker, Clare, Clark, Susan J.

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STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation von Masle-Farquhar, Etienne, Jackson, Katherine J.L., Peters, Timothy J., Al-Eryani, Ghamdan, Singh, Mandeep, Payne, Kathryn J., Rao, Geetha, Avery, Danielle T., Apps, Gabrielle, Kingham, Jennifer, Jara, Christopher J., Skvortsova, Ksenia, Swarbrick, Alexander, Ma, Cindy S., Suan, Daniel, Uzel, Gulbu, Chua, Ignatius, Leiding, Jennifer W., Heiskanen, Kaarina, Preece, Kahn, Kainulainen, Leena, O’Sullivan, Michael, Cooper, Megan A., Seppänen, Mikko R.J., Mustjoki, Satu, Brothers, Shannon, Vogel, Tiphanie P., Brink, Robert, Tangye, Stuart G., Reed, Joanne H., Goodnow, Christopher C.

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Brief Report: Identification of a Pathogenic Variant in TREX1 in Early‐Onset Cerebral Systemic Lupus Erythematosus by Whole‐Exome Sequencing von Ellyard, Julia I., Jerjen, Rebekka, Martin, Jaime L., Lee, Adrian Y. S., Field, Matthew A., Jiang, Simon H., Cappello, Jean, Naumann, Svenja K., Andrews, T. Daniel, Scott, Hamish S., Casarotto, Marco G., Goodnow, Christopher C., Chaitow, Jeffrey, Pascual, Virginia, Hertzog, Paul, Alexander, Stephen I., Cook, Matthew C., Vinuesa, Carola G.

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity von Rui, Lixin, Vinuesa, Carola G, Domaschenz, Heather, Goodnow, Christopher C, Lambe, Teresa, Bell, John I, Hill, Kim M, Cornall, Richard J, Cook, Matthew C, Copley, Richard R, Angelucci, Constanza, Whittle, Belinda, Roberts, Ian S, Yu, Di, Athanasopoulos, Vicki

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B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A von Bergmann, Hannes, Yabas, Mehmet, Short, Alanna, Miosge, Lisa, Barthel, Nadine, Teh, Charis E, Roots, Carla M, Bull, Katherine R, Jeelall, Yogesh, Horikawa, Keisuke, Whittle, Belinda, Balakishnan, Bhavani, Sjollema, Geoff, Bertram, Edward M, Mackay, Fabienne, Rimmer, Andrew J, Cornall, Richard J, Field, Matthew A, Andrews, T Daniel, Goodnow, Christopher C, Enders, Anselm

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A Novel Heterozygous Variant in AICDA Impairs Ig Class Switching and Somatic Hypermutation in Human B Cells and is Associated with Autosomal Dominant HIGM2 Syndrome von Della Mina, Erika, Jackson, Katherine J. L., Crawford, Alexander J. I., Faulks, Megan L., Pathmanandavel, Karrnan, Acquarola, Nicolino, O’Sullivan, Michael, Kerre, Tessa, Naesens, Leslie, Claes, Karlien, Goodnow, Christopher C., Haerynck, Filomeen, Kracker, Sven, Meyts, Isabelle, D’Orsogna, Lloyd J., Ma, Cindy S., Tangye, Stuart G.

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Identifying the MAGUK Protein Carma-1 as a Central Regulator of Humoral Immune Responses and Atopy by Genome-Wide Mouse Mutagenesis von Jun, Jesse E., Wilson, Lauren E., Vinuesa, Carola G., Lesage, Sylvie, Blery, Mathieu, Miosge, Lisa A., Cook, Matthew C., Kucharska, Edyta M., Hara, Hiromitsu, Penninger, Josef M., Domashenz, Heather, Hong, Nancy A., Glynne, Richard J., Nelms, Keats A., Goodnow, Christopher C.

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Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability von Burnett, Deborah L., Jackson, Katherine J.L., Langley, David B., Aggarwal, Anupriya, Stella, Alberto Ospina, Johansen, Matt D., Balachandran, Harikrishnan, Lenthall, Helen, Rouet, Romain, Walker, Gregory, Saunders, Bernadette M., Singh, Mandeep, Li, Hui, Henry, Jake Y., Jackson, Jennifer, Stewart, Alastair G., Witthauer, Franka, Spence, Matthew A., Hansbro, Nicole G., Jackson, Colin, Schofield, Peter, Milthorpe, Claire, Martinello, Marianne, Schulz, Sebastian R., Roth, Edith, Kelleher, Anthony, Emery, Sean, Britton, Warwick J., Rawlinson, William D., Karl, Rudolfo, Schäfer, Simon, Winkler, Thomas H., Brink, Robert, Bull, Rowena A., Hansbro, Philip M., Jäck, Hans-Martin, Turville, Stuart, Christ, Daniel, Goodnow, Christopher C.

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Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice von Arsov, Todor, Larter, Claire Z., Nolan, Christopher J., Petrovsky, Nikolai, Goodnow, Christopher C., Teoh, Narcissus C., Yeh, Matthew M., Farrell, Geoffrey C.

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Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA von Di Yu, Silva, Diego G, Tan, Andy Hee-Meng, Simpson, Nicholas, Hutloff, Andreas, Lam, Kong Peng, Giles, Keith M, Leedman, Peter J, Vinuesa, Carola G, Goodnow, Christopher C, Hu, Xin, Athanasopoulos, Vicki

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STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis von Pelham, Simon J, Caldirola, Maria Soledad, Avery, Danielle T, Mackie, Joseph, Rao, Geetha, Gothe, Florian, Peters, Timothy J, Guerin, Antoine, Neumann, David, Vokurkova, Doris, Hwa, Vivian, Zhang, Wenming, Lyu, Shu-Chen, Chang, Iris, Manohar, Monali, Nadeau, Kari C, Gaillard, Maria Isabel, Bezrodnik, Liliana, Iotova, Violeta, Zwirner, Norberto Walter, Gutierrez, Mavel, Al-Herz, Waleed, Goodnow, Christopher C, Vargas-Hernández, Alexander, Forbes Satter, Lisa R, Hambleton, Sophie, Deenick, Elissa K, Ma, Cindy S, Tangye, Stuart G

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SnapShot: Interactions between B Cells and T Cells von Tangye, Stuart G., Brink, Robert, Goodnow, Christopher C., Phan, Tri Giang

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Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients von Rouet, Romain, Henry, Jake Y., Johansen, Matt D., Sobti, Meghna, Balachandran, Harikrishnan, Langley, David B., Walker, Gregory J., Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Mazigi, Ohan, Schofield, Peter, Burnett, Deborah L., Brown, Simon H. J., Martinello, Marianne, Hudson, Bernard, Gilroy, Nicole, Post, Jeffrey J., Kelleher, Anthony, Jäck, Hans-Martin, Goodnow, Christopher C., Turville, Stuart G., Rawlinson, William D., Bull, Rowena A., Stewart, Alastair G., Hansbro, Philip M., Christ, Daniel

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Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies von Rouet, Romain, Mazigi, Ohan, Walker, Gregory J., Langley, David B., Sobti, Meghna, Schofield, Peter, Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Henry, Jake Y., Abayasingam, Arunasingam, Burnett, Deborah, Kelleher, Anthony, Brink, Robert, Bull, Rowena A., Turville, Stuart, Stewart, Alastair G., Goodnow, Christopher C., Rawlinson, William D., Christ, Daniel

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