Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization von Reed, Joanne H, Jackson, Jennifer, Christ, Daniel, Goodnow, Christopher C

Volltext

High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes von Singh, Mandeep, Al-Eryani, Ghamdan, Carswell, Shaun, Ferguson, James M., Blackburn, James, Barton, Kirston, Roden, Daniel, Luciani, Fabio, Giang Phan, Tri, Junankar, Simon, Jackson, Katherine, Goodnow, Christopher C., Smith, Martin A., Swarbrick, Alexander

Volltext

Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity von Burnett, Deborah L., Reed, Joanne H., Christ, Daniel, Goodnow, Christopher C.

Volltext

Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate von Peters, Timothy J, Buckley, Michael J, Chen, Yunshun, Smyth, Gordon K, Goodnow, Christopher C, Clark, Susan J

Volltext

HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse von Lim, Shu Ly, Qu, Zhi Peng, Kortschak, R Daniel, Lawrence, David M, Geoghegan, Joel, Hempfling, Anna-Lena, Bergmann, Martin, Goodnow, Christopher C, Ormandy, Christopher J, Wong, Lee, Mann, Jeff, Scott, Hamish S, Jamsai, Duangporn, Adelson, David L, O'Bryan, Moira K

Volltext

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination von Burnett, Deborah L, Langley, David B, Schofield, Peter, Hermes, Jana R, Chan, Tyani D, Jackson, Jennifer, Bourne, Katherine, Reed, Joanne H, Patterson, Kate, Porebski, Benjamin T, Brink, Robert, Christ, Daniel, Goodnow, Christopher C

Volltext

Comparison of predicted and actual consequences of missense mutations von Miosge, Lisa A., Field, Matthew A., Sontani, Yovina, Cho, Vicky, Johnson, Simon, Palkova, Anna, Balakishnan, Bhavani, Liang, Rong, Zhang, Yafei, Lyon, Stephen, Beutler, Bruce, Whittle, Belinda, Bertram, Edward M., Enders, Anselm, Goodnow, Christopher C., Andrews, T. Daniel

Volltext

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity von Sabouri, Zahra, Schofield, Peter, Horikawa, Keisuke, Spierings, Emily, Kipling, David, Randall, Katrina L, Langley, David, Roome, Brendan, Vazquez-Lombardi, Rodrigo, Rouet, Romain, Hermes, Jana, Chan, Tyani D, Brink, Robert, Dunn-Walters, Deborah K, Christ, Daniel, Goodnow, Christopher C

Volltext

Two levels of protection for the B cell genome during somatic hypermutation von Schatz, David G, Liu, Man, Duke, Jamie L, Richter, Daniel J, Vinuesa, Carola G, Goodnow, Christopher C, Kleinstein, Steven H

Volltext

Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation von Pratama, Alvin, Ramiscal, Roybel R., Silva, Diego G., Das, Souvik K., Athanasopoulos, Vicki, Fitch, Jessica, Botelho, Natalia K., Chang, Pheh-Ping, Hu, Xin, Hogan, Jennifer J., Maña, Paula, Bernal, David, Korner, Heinrich, Yu, Di, Goodnow, Christopher C., Cook, Matthew C., Vinuesa, Carola G.

Volltext

SAMD9L autoinflammatory or ataxia pancytopenia disease mutations activate cell-autonomous translational repression von Russell, Amanda J., Gray, Paul E., Ziegler, John B., Kim, Yae Jean, Smith, Sandy, Sewell, William A., Goodnow, Christopher C.

Volltext

IgD attenuates the IgM-induced anergy response in transitional and mature B cells von Sabouri, Zahra, Perotti, Samuel, Spierings, Emily, Humburg, Peter, Yabas, Mehmet, Bergmann, Hannes, Horikawa, Keisuke, Roots, Carla, Lambe, Samantha, Young, Clara, Andrews, T. Dan, Field, Matthew, Enders, Anselm, Reed, Joanne H., Goodnow, Christopher C.

Volltext

Cellular and genetic mechanisms of self tolerance and autoimmunity von Goodnow, Christopher C, Sprent, Jonathon, de St Groth, Barbara Fazekas, Vinuesa, Carola G

Volltext

Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice von Masle-Farquhar, Etienne, Russell, Amanda, Li, Yangguang, Zhu, Fen, Rui, Lixin, Brink, Robert, Goodnow, Christopher C.

Volltext

DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns von Skvortsova, Ksenia, Masle-Farquhar, Etienne, Luu, Phuc-Loi, Song, Jenny Z., Qu, Wenjia, Zotenko, Elena, Gould, Cathryn M., Du, Qian, Peters, Timothy J., Colino-Sanguino, Yolanda, Pidsley, Ruth, Nair, Shalima S., Khoury, Amanda, Smith, Grady C., Miosge, Lisa A., Reed, Joanne H., Kench, James G., Rubin, Mark A., Horvath, Lisa, Bogdanovic, Ozren, Lim, Sue Mei, Polo, Jose M., Goodnow, Christopher C., Stirzaker, Clare, Clark, Susan J.

Volltext

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis von Heazlewood, Chad K, Cook, Matthew C, Eri, Rajaraman, Price, Gareth R, Tauro, Sharyn B, Taupin, Douglas, Thornton, David J, Png, Chin Wen, Crockford, Tanya L, Cornall, Richard J, Adams, Rachel, Kato, Masato, Nelms, Keats A, Hong, Nancy A, Florin, Timothy H J, Goodnow, Christopher C, McGuckin, Michael A

Volltext

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells von Gray, Daniel H.D., Seach, Natalie, Ueno, Tomoo, Milton, Morag K., Liston, Adrian, Lew, Andrew M., Goodnow, Christopher C., Boyd, Richard L.

Volltext

Murine LRBA deficiency causes CTLA‐4 deficiency in Tregs without progression to immune dysregulation von Burnett, Deborah L, Parish, Ian A, Masle‐Farquhar, Etienne, Brink, Robert, Goodnow, Christopher C

Volltext

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation von Tze, Lina E, Horikawa, Keisuke, Domaschenz, Heather, Howard, Debbie R, Roots, Carla M, Rigby, Robert J, Way, David A, Ohmura-Hoshino, Mari, Ishido, Satoshi, Andoniou, Christopher E, Degli-Esposti, Mariapia A, Goodnow, Christopher C

Volltext

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance von Hubert, François-Xavier, Kinkel, Sarah A., Davey, Gayle M., Phipson, Belinda, Mueller, Scott N., Liston, Adrian, Proietto, Anna I., Cannon, Ping Z.F., Forehan, Simon, Smyth, Gordon K., Wu, Li, Goodnow, Christopher C., Carbone, Francis R., Scott, Hamish S., Heath, William R.

Volltext