Identifying a high fraction of the human genome to be under selective constraint using GERP von Davydov, Eugene V, Goode, David L, Sirota, Marina, Cooper, Gregory M, Sidow, Arend, Batzoglou, Serafim

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PRMT5 and CDK4/6 inhibition result in distinctive patterns of alternative splicing in melanoma von Chan, Lok Hang, Wang, Peihan, Abuhammad, Shatha, Lim, Lydia Rui Jia, Cursons, Joseph, Sheppard, Karen E, Goode, David L

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Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments von Feng, Yuzhou, Yang, Tianpei, Zhu, John, Li, Mabel, Doyle, Maria, Ozcoban, Volkan, Bass, Greg T., Pizzolla, Angela, Cain, Lachlan, Weng, Sirui, Pasam, Anupama, Kocovski, Nikolce, Huang, Yu-Kuan, Keam, Simon P., Speed, Terence P., Neeson, Paul J., Pearson, Richard B., Sandhu, Shahneen, Goode, David L., Trigos, Anna S.

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Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer von Trigos, Anna S, Pearson, Richard B, Papenfuss, Anthony T, Goode, David L

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MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer von Cipponi, Arcadi, Goode, David L., Bedo, Justin, McCabe, Mark J., Pajic, Marina, Croucher, David R., Rajal, Alvaro Gonzalez, Junankar, Simon R., Saunders, Darren N., Lobachevsky, Pavel, Papenfuss, Anthony T., Nessem, Danielle, Nobis, Max, Warren, Sean C., Timpson, Paul, Cowley, Mark, Vargas, Ana C., Qiu, Min R., Generali, Daniele G., Keerthikumar, Shivakumar, Nguyen, Uyen, Corcoran, Niall M., Long, Georgina Y., Blay, Jean-Yves, Thomas, David M.

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Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins von Trigos, Anna S, Bongiovanni, Felicia, Zhang, Yangyi, Zethoven, Maia, Tothill, Richard, Pearson, Richard, Papenfuss, Anthony T, Goode, David L

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The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes von Montgomery, Stephen B, Goode, David L, Kvikstad, Erika, Albers, Cornelis A, Zhang, Zhengdong D, Mu, Xinmeng Jasmine, Ananda, Guruprasad, Howie, Bryan, Karczewski, Konrad J, Smith, Kevin S, Anaya, Vanessa, Richardson, Rhea, Davis, Joe, MacArthur, Daniel G, Sidow, Arend, Duret, Laurent, Gerstein, Mark, Makova, Kateryna D, Marchini, Jonathan, McVean, Gil, Lunter, Gerton

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Single-nucleotide evolutionary constraint scores highlight disease-causing mutations von Cooper, Gregory M, Goode, David L, Ng, Sarah B, Sidow, Arend, Bamshad, Michael J, Shendure, Jay, Nickerson, Deborah A

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High frequency of germline TP53 mutations in a prospective adult-onset sarcoma cohort von Mitchell, Gillian, Ballinger, Mandy L, Wong, Stephen, Hewitt, Chelsee, James, Paul, Young, Mary-Anne, Cipponi, Arcadi, Pang, Tiffany, Goode, David L, Dobrovic, Alex, Thomas, David M

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Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors von Trigos, Anna S., Pearson, Richard B., Papenfuss, Anthony T., Goode, David L.

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The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential von Wong, Stephen H.K., Goode, David L., Iwasaki, Masayuki, Wei, Michael C., Kuo, Hsu-Ping, Zhu, Li, Schneidawind, Dominik, Duque-Afonso, Jesus, Weng, Ziming, Cleary, Michael L.

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How the evolution of multicellularity set the stage for cancer von Trigos, Anna S, Pearson, Richard B, Papenfuss, Anthony T, Goode, David L

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Evolutionary constraint facilitates interpretation of genetic variation in resequenced human genomes von Goode, David L, Cooper, Gregory M, Schmutz, Jeremy, Dickson, Mark, Gonzales, Eidelyn, Tsai, Ming, Karra, Kalpana, Davydov, Eugene, Batzoglou, Serafim, Myers, Richard M, Sidow, Arend

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Copy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formalin-fixed paraffin embedded tumor tissue von Kader, Tanjina, Goode, David L, Wong, Stephen Q, Connaughton, Jacquie, Rowley, Simone M, Devereux, Lisa, Byrne, David, Fox, Stephen B, Mir Arnau, Gisela, Tothill, Richard W, Campbell, Ian G, Gorringe, Kylie L

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Bioinformatics pipelines for targeted resequencing and whole-exome sequencing of human and mouse genomes: a virtual appliance approach for instant deployment von Li, Jason, Doyle, Maria A, Saeed, Isaam, Wong, Stephen Q, Mar, Victoria, Goode, David L, Caramia, Franco, Doig, Ken, Ryland, Georgina L, Thompson, Ella R, Hunter, Sally M, Halgamuge, Saman K, Ellul, Jason, Dobrovic, Alexander, Campbell, Ian G, Papenfuss, Anthony T, McArthur, Grant A, Tothill, Richard W

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Salmonella phage ST64B encodes a member of the SseK/NleB effector family von Brown, Nat F, Coombes, Brian K, Bishop, Jenna L, Wickham, Mark E, Lowden, Michael J, Gal-Mor, Ohad, Goode, David L, Boyle, Erin C, Sanderson, Kristy L, Finlay, B Brett

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Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex von Belov, Katherine, Deakin, Janine E, Papenfuss, Anthony T, Baker, Michelle L, Melman, Sandra D, Siddle, Hannah V, Gouin, Nicolas, Goode, David L, Sargeant, Tobias J, Robinson, Mark D, Wakefield, Matthew J, Mahony, Shaun, Cross, Joseph G R, Benos, Panayiotis V, Samollow, Paul B, Speed, Terence P, Graves, Jennifer A Marshall, Miller, Robert D

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Androgen receptor enhancer amplification in matched patient‐derived xenografts of primary and castrate‐resistant prostate cancer von Porter, Laura H, Bakshi, Andrew, Pook, David, Clark, Ashlee, Clouston, David, Kourambas, John, Goode, David L, Risbridger, Gail P, Taylor, Renea A, Lawrence, Mitchell G

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Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia von Bell, Charles C., Fennell, Katie A., Chan, Yih-Chih, Rambow, Florian, Yeung, Miriam M., Vassiliadis, Dane, Lara, Luis, Yeh, Paul, Martelotto, Luciano G., Rogiers, Aljosja, Kremer, Brandon E., Barbash, Olena, Mohammad, Helai P., Johanson, Timothy M., Burr, Marian L., Dhar, Arindam, Karpinich, Natalie, Tian, Luyi, Tyler, Dean S., MacPherson, Laura, Shi, Junwei, Pinnawala, Nathan, Yew Fong, Chun, Papenfuss, Anthony T., Grimmond, Sean M., Dawson, Sarah-Jane, Allan, Rhys S., Kruger, Ryan G., Vakoc, Christopher R., Goode, David L., Naik, Shalin H., Gilan, Omer, Lam, Enid Y. N., Marine, Jean-Christophe, Prinjha, Rab K., Dawson, Mark A.

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Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy von Lawrence, Mitchell G., Obinata, Daisuke, Sandhu, Shahneen, Selth, Luke A., Wong, Stephen Q., Porter, Laura H., Lister, Natalie, Pook, David, Pezaro, Carmel J., Goode, David L., Rebello, Richard J., Clark, Ashlee K., Papargiris, Melissa, Van Gramberg, Jenna, Hanson, Adrienne R., Banks, Patricia, Wang, Hong, Niranjan, Birunthi, Keerthikumar, Shivakumar, Hedwards, Shelley, Huglo, Alisee, Yang, Rendong, Henzler, Christine, Li, Yingming, Lopez-Campos, Fernando, Castro, Elena, Toivanen, Roxanne, Azad, Arun, Bolton, Damien, Goad, Jeremy, Grummet, Jeremy, Harewood, Laurence, Kourambas, John, Lawrentschuk, Nathan, Moon, Daniel, Murphy, Declan G., Sengupta, Shomik, Snow, Ross, Thorne, Heather, Mitchell, Catherine, Pedersen, John, Clouston, David, Norden, Sam, Ryan, Andrew, Dehm, Scott M., Tilley, Wayne D., Pearson, Richard B., Hannan, Ross D., Frydenberg, Mark, Furic, Luc, Taylor, Renea A., Risbridger, Gail P.

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