Current challenges and emerging opportunities of CAR-T cell therapies von Abreu, Teresa R., Fonseca, Nuno A., Gonçalves, Nélio, Moreira, João Nuno

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Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors von Viana da Silva, Silvia, Haberl, Matthias Georg, Zhang, Pei, Bethge, Philipp, Lemos, Cristina, Gonçalves, Nélio, Gorlewicz, Adam, Malezieux, Meryl, Gonçalves, Francisco Q., Grosjean, Noëlle, Blanchet, Christophe, Frick, Andreas, Nägerl, U Valentin, Cunha, Rodrigo A., Mulle, Christophe

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Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine von Gonçalves, Francisco Q., Lopes, João P., Silva, Henrique B., Lemos, Cristina, Silva, António C., Gonçalves, Nélio, Tomé, Ângelo R., Ferreira, Samira G., Canas, Paula M., Rial, Daniel, Agostinho, Paula, Cunha, Rodrigo A.

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Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress von Dias, Liliana, Pochmann, Daniela, Lemos, Cristina, Silva, Henrique B., Real, Joana I., Gonçalves, Francisco Q., Rial, Daniel, Gonçalves, Nélio, Simões, Ana Patrícia, Ferreira, Samira G., Agostinho, Paula, Cunha, Rodrigo A., Tomé, Angelo R.

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Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia von Gonçalves, Nélio, Simões, Ana T., Prediger, Rui D., Hirai, Hirokazu, Cunha, Rodrigo A., Pereira de Almeida, Luís

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Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A recept... von Gomes, Catarina, Ferreira, Raquel, George, Jimmy, Sanches, Rui, Rodrigues, Diana I, Gonçalves, Nélio, Cunha, Rodrigo A

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Cancer Stem Cells and Nucleolin as Drivers of Carcinogenesis von Carvalho, Laura Sofia, Goncalves, Nelio, Fonseca, Nuno Andre, Moreira, Joao Nuno

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Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease von Simões, Ana Teresa, Gonçalves, Nélio, Nobre, Rui Jorge, Duarte, Carlos Bandeira, Pereira de Almeida, Luís

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Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory von Simões, Ana Patrícia, Machado, Nuno J, Gonçalves, Nélio, Kaster, Manuella P, Simões, Ana T, Nunes, Ana, Pereira de Almeida, Luís, Goosens, Ki Ann, Rial, Daniel, Cunha, Rodrigo A

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Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction von Augusto, Elisabete, Gonçalves, Francisco Q., Real, Joana E., Silva, Henrique B., Pochmann, Daniela, Silva, Tiago S., Matos, Marco, Gonçalves, Nélio, Tomé, Ângelo R., Chen, Jiang-Fan, Canas, Paula M., Cunha, Rodrigo A.

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Adenosine A2A receptors control synaptic remodeling in the adult brain von Xu, Xinli, Beleza, Rui O., Gonçalves, Francisco Q., Valbuena, Sergio, Alçada-Morais, Sofia, Gonçalves, Nélio, Magalhães, Joana, Rocha, João M. M., Ferreira, Sofia, Figueira, Ana S. G., Lerma, Juan, Cunha, Rodrigo A., Rodrigues, Ricardo J., Marques, Joana M.

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Depression as a Glial-Based Synaptic Dysfunction von Rial, Daniel, Lemos, Cristina, Pinheiro, Helena, Duarte, Joana M, Gonçalves, Francisco Q, Real, Joana I, Prediger, Rui D, Gonçalves, Nélio, Gomes, Catarina A, Canas, Paula M, Agostinho, Paula, Cunha, Rodrigo A

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Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease von Gonçalves, Nélio, Simões, Ana T., Cunha, Rodrigo A., de Almeida, Luís Pereira

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Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado―Joseph disease von SIMOES, Ana T, GONCALVES, Nélio, KOEPPEN, Arnulf, DEGLON, Nicole, KÜGLER, Sebastian, DUARTE, Carlos Bandeira, DE ALMEIDA, Luís Pereira

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Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease von Gonçalves, Francisco Q., Matheus, Filipe C., Silva, Henrique B., Real, Joana I., Rial, Daniel, Rodrigues, Ricardo J., Oses, Jean-Pierre, Silva, António C., Gonçalves, Nélio, Prediger, Rui D., Tomé, Ângelo R., Cunha, Rodrigo A.

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Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease von Gonçalves, Nélio, Simões, Ana T, Cunha, Rodrigo A, de Almeida, Luís Pereira

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GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure von Fonseca, Nuno A., Gregório, Ana C., Mendes, Vera M., Lopes, Rui, Abreu, Teresa, Gonçalves, Nélio, Manadas, Bruno, Lacerda, Manuela, Figueiredo, Paulo, Pereira, Marta, Gaspar, Manuela, Colelli, Fabiana, Pesce, Daniela, Signorino, Giacomo, Focareta, Laura, Fucci, Alessandra, Cardile, Francesco, Pisano, Claudio, Cruz, Tony, Almeida, Luís, Moura, Vera, Simões, Sérgio, Moreira, João N.

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Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease von Duarte-Neves, Joana, Gonçalves, Nélio, Cunha-Santos, Janete, Simões, Ana Teresa, den Dunnen, Wilfred F A, Hirai, Hirokazu, Kügler, Sebastian, Cavadas, Cláudia, Pereira de Almeida, Luís

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Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation von Morató, Xavier, Luján, Rafael, Gonçalves, Nélio, Watanabe, Masahiko, Altafaj, Xavier, Carvalho, Ana Luísa, Fernández-Dueñas, Víctor, Cunha, Rodrigo A, Ciruela, Francisco

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Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention in Lung Cancer von Valério-Fernandes, Ângela, Fonseca, Nuno A, Gonçalves, Nélio, Cruz, Ana F, Pereira, Marta I, Gregório, Ana C, Moura, Vera, Ladeirinha, Ana F, Alarcão, Ana, Gonçalves, Joana, Abrunhosa, Antero, Melo, Joana B, Carvalho, Lina, Simões, Sérgio, Moreira, João N

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