Managing the challenge of chemically reactive metabolites in drug development von Park, B. Kevin, Tweedie, Donald J, Boobis, Alan, Clarke, Stephen, Goldring, Chris E. P, Jones, David, Kenna, J. Gerry, Lambert, Craig, Laverty, Hugh G, Naisbitt, Dean J, Nelson, Sidney, Nicoll-Griffith, Deborah A, Obach, R. Scott, Routledge, Philip, Smith, Dennis A, Vermeulen, Nico, Williams, Dominic P, Wilson, Ian D, Baillie, Thomas A

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Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile von Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.

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Assessing the Safety of Stem Cell Therapeutics von Goldring, Chris E.P., Duffy, Paul A., Benvenisty, Nissim, Andrews, Peter W., Ben-David, Uri, Eakins, Rowena, French, Neil, Hanley, Neil A., Kelly, Lorna, Kitteringham, Neil R., Kurth, Jens, Ladenheim, Deborah, Laverty, Hugh, McBlane, James, Narayanan, Gopalan, Patel, Sara, Reinhardt, Jens, Rossi, Annamaria, Sharpe, Michaela, Park, B. Kevin

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Stem cell models as an in vitro model for predictive toxicology von Lynch, Stephen, Pridgeon, Chris S, Duckworth, Carrie A, Sharma, Parveen, Park, B Kevin, Goldring, Chris E P

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Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury von Ali, Serat-E, Waddington, James C, Lister, Adam, Sison-Young, Rowena, Jones, Robert P, Rehman, Adeeb H, Goldring, Chris E P, Naisbitt, Dean J, Meng, Xiaoli

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Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes von Goldring, Chris E. P, Kitteringham, Neil R, Jenkins, Rosalind, Lovatt, Cerys A, Randle, Laura E, Abdullah, Azman, Owen, Andrew, Liu, Xiaoping, Butler, Philip J, Williams, Dominic P, Metcalfe, Peter, Berens, Christian, Hillen, Wolfgang, Foster, Brian, Simpson, Alec, McLellan, Lesley, Park, B. Kevin

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Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms von Pridgeon, Chris S., Schlott, Constanze, Wong, Min Wei, Heringa, Minne B., Heckel, Tobias, Leedale, Joe, Launay, Laurence, Gryshkova, Vitalina, Przyborski, Stefan, Bearon, Rachel N., Wilkinson, Emma L., Ansari, Tahera, Greenman, John, Hendriks, Delilah F. G., Gibbs, Sue, Sidaway, James, Sison-Young, Rowena L., Walker, Paul, Cross, Mike J., Park, B. Kevin, Goldring, Chris E. P.

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Stem cell‐derived hepatocytes as a predictive model for drug‐induced liver injury: are we there yet? von Kia, Richard, Sison, Rowena L. C., Heslop, James, Kitteringham, Neil R., Hanley, Neil, Mills, John S., Park, B. Kevin, Goldring, Chris E. P.

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In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells von Pridgeon, Chris S, Forootan, Shiva Seyed, Zhang, Fang, Harper, Nicholas, Palmer, Daniel, Weightmann, Richard, Gregory, Sian, Hewitt, Zoe, Baker, Duncan, Halliwell, Jason, Moore, Harry, Ricci, Emanuele, Andrews, Peter W, Poptani, Harish, Hay, David C, Park, B Kevin, Goldring, Chris E P

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MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity von Kia, Richard, Kelly, Lorna, Sison-Young, Rowena L C, Zhang, Fang, Pridgeon, Chris S, Heslop, James A, Metcalfe, Pete, Kitteringham, Neil R, Baxter, Melissa, Harrison, Sean, Hanley, Neil A, Burke, Zoë D, Storm, Mike P, Welham, Melanie J, Tosh, David, Küppers-Munther, Barbara, Edsbagge, Josefina, Starkey Lewis, Philip J, Bonner, Frank, Harpur, Ernie, Sidaway, James, Bowes, Joanne, Fenwick, Stephen W, Malik, Hassan, Goldring, Chris E P, Park, B Kevin

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Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies von Scarfe, Lauren, Brillant, Nathalie, Kumar, J. Dinesh, Ali, Noura, Alrumayh, Ahmed, Amali, Mohammed, Barbellion, Stephane, Jones, Vendula, Niemeijer, Marije, Potdevin, Sophie, Roussignol, Gautier, Vaganov, Anatoly, Barbaric, Ivana, Barrow, Michael, Burton, Neal C., Connell, John, Dazzi, Francesco, Edsbagge, Josefina, French, Neil S., Holder, Julie, Hutchinson, Claire, Jones, David R., Kalber, Tammy, Lovatt, Cerys, Lythgoe, Mark F., Patel, Sara, Patrick, P. Stephen, Piner, Jacqueline, Reinhardt, Jens, Ricci, Emanuelle, Sidaway, James, Stacey, Glyn N., Starkey Lewis, Philip J., Sullivan, Gareth, Taylor, Arthur, Wilm, Bettina, Poptani, Harish, Murray, Patricia, Goldring, Chris E. P., Park, B. Kevin

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Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice von Randle, Laura E, Goldring, Chris E.P, Benson, Craig A, Metcalfe, Peter N, Kitteringham, Neil R, Park, B. Kevin, Williams, Dominic P

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Assessing the Safety of Stem Cell Therapeutics von Goldring, Chris E.P., Duffy, Paul A., Benvenisty, Nissim, Andrews, Peter W., Ben-David, Uri, Eakins, Rowena, French, Neil, Hanley, Neil A., Kelly, Lorna, Kitteringham, Neil R., Kurth, Jens, Ladenheim, Deborah, Laverty, Hugh, McBlane, James, Narayanan, Gopalan, Patel, Sara, Reinhardt, Jens, Rossi, Annamaria, Sharpe, Michaela, Park, B. Kevin

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of... von Godoy, Patricio, Hewitt, Nicola J., Albrecht, Ute, Andersen, Melvin E., Ansari, Nariman, Bhattacharya, Sudin, Bode, Johannes Georg, Bolleyn, Jennifer, Borner, Christoph, Böttger, Jan, Braeuning, Albert, Budinsky, Robert A., Burkhardt, Britta, Cameron, Neil R., Camussi, Giovanni, Cho, Chong-Su, Choi, Yun-Jaie, Craig Rowlands, J., Dahmen, Uta, Damm, Georg, Dirsch, Olaf, Donato, María Teresa, Dong, Jian, Dooley, Steven, Drasdo, Dirk, Eakins, Rowena, Ferreira, Karine Sá, Fonsato, Valentina, Fraczek, Joanna, Gebhardt, Rolf, Gibson, Andrew, Glanemann, Matthias, Goldring, Chris E. P., Gómez-Lechón, María José, Groothuis, Geny M. M., Gustavsson, Lena, Guyot, Christelle, Hallifax, David, Hammad, Seddik, Hayward, Adam, Häussinger, Dieter, Hellerbrand, Claus, Hewitt, Philip, Hoehme, Stefan, Holzhütter, Hermann-Georg, Houston, J. Brian, Hrach, Jens, Ito, Kiyomi, Jaeschke, Hartmut, Keitel, Verena, Kelm, Jens M., Kevin Park, B., Kordes, Claus, Kullak-Ublick, Gerd A., LeCluyse, Edward L., Lu, Peng, Luebke-Wheeler, Jennifer, Lutz, Anna, Maltman, Daniel J., Matz-Soja, Madlen, McMullen, Patrick, Merfort, Irmgard, Messner, Simon, Meyer, Christoph, Mwinyi, Jessica, Naisbitt, Dean J., Nussler, Andreas K., Olinga, Peter, Pampaloni, Francesco, Pi, Jingbo, Pluta, Linda, Przyborski, Stefan A., Ramachandran, Anup, Rogiers, Vera, Rowe, Cliff, Schelcher, Celine, Schmich, Kathrin, Schwarz, Michael, Singh, Bijay, Stelzer, Ernst H. K., Stieger, Bruno, Stöber, Regina, Sugiyama, Yuichi, Tetta, Ciro, Thasler, Wolfgang E., Vanhaecke, Tamara, Vinken, Mathieu, Weiss, Thomas S., Widera, Agata, Woods, Courtney G., Xu, Jinghai James, Yarborough, Kathy M., Hengstler, Jan G.

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P263 Irinotecan induces a rapid increase in enteroid permeability von Turnbull, James L, Lynch, Stephen, Mark Pritchard, D, Goldring, Chris EP, Duckworth, Carrie A

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Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keapl defence response pathway in CD-1 mice von RANDLE, Laura E, GOLDRING, Chris E. P, BENSON, Craig A, METCALFE, Peter N, KITTERINGHAM, Neil R, PARK, B. Kevin, WILLIAMS, Dominic P

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Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes von Goldring, Chris E P, Kitteringham, Neil R, Jenkins, Rosalind, Lovatt, Cerys A

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Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy von Lister, Adam, Nedjadi, Taoufik, Kitteringham, Neil R, Campbell, Fiona, Costello, Eithne, Lloyd, Bryony, Copple, Ian M, Williams, Samantha, Owen, Andrew, Neoptolemos, John P, Goldring, Chris E, Park, B Kevin

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Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study von Bell, Catherine C, Dankers, Anita C A, Lauschke, Volker M, Sison-Young, Rowena, Jenkins, Roz, Rowe, Cliff, Goldring, Chris E, Park, Kevin, Regan, Sophie L, Walker, Tracy, Schofield, Chris, Baze, Audrey, Foster, Alison J, Williams, Dominic P, van de Ven, Amy W M, Jacobs, Frank, Houdt, Jos van, Lähteenmäki, Tuula, Snoeys, Jan, Juhila, Satu, Richert, Lysiane, Ingelman-Sundberg, Magnus

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Circulating microRNAs as potential markers of human drug‐induced liver injury von Starkey Lewis, Philip J., Dear, James, Platt, Vivien, Simpson, Kenneth J., Craig, Darren G.N., Antoine, Daniel J., French, Neil S., Dhaun, Neeraj, Webb, David J., Costello, Eithne M., Neoptolemos, John P., Moggs, Jonathan, Goldring, Chris E., Park, B. Kevin

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