THU0127 Pharmacodynamics of A Novel JAK1 Selective Inhibitor in Rat Arthritis and Anemia Models and in Healthy Human Subjects von Voss, J., Graff, C., Schwartz, A., Hyland, D., Argiriadi, M., Camp, H., Dowding, L., Friedman, M., Frank, K., George, J., Goedken, E., Lo Schiavo, G., Morytko, M., O'Brien, R., Padley, R., Rozema, M., Rosebraugh, M., Stewart, K., Wallace, G., Wishart, N., Murtaza, A., Olson, L.

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Co-crystal of Escherichia coli RNase HI with Mn2+ Ions Reveals Two Divalent Metals Bound in the Active Site von Goedken, Eric R., Marqusee, Susan

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Divalent metal cofactor binding in the kinetic folding trajectory of Escherichia coli ribonuclease HI von GOEDKEN, ERIC R., KECK, JAMES L., BERGER, JAMES M., MARQUSEE, SUSAN

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Activation/attenuation model for RNase H. A one-metal mechanism with second-metal inhibition von Keck, J L, Goedken, E R, Marqusee, S

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The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds von Toth, E A, Worby, C, Dixon, J E, Goedken, E R, Marqusee, S, Yeates, T O

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Native-state energetics of a thermostabilized variant of ribonuclease HI von Goedken, E R, Marqusee, S

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Importance of the C-Terminal Helix to the Stability and Enzymatic Activity of Escherichia coli Ribonuclease H von Goedken, Eric R, Raschke, Tanya M, Marqusee, Susan

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Decreased expression of carboxypeptidase E protein is correlated to estrogen-induction of rat pituitary tumors von Gregg, D., Goedken, E., Gaikin, M., Wendell, D., Gorski, J.

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Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium von Argiriadi, Maria A, Goedken, Eric R, Bruck, Irina, O'Donnell, Mike, Kuriyan, John

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Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding von Goedken, Eric R, Levitus, Marcia, Johnson, Aaron, Bustamante, Carlos, O'Donnell, Mike, Kuriyan, John

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Folding the ribonuclease H domain of Moloney murine leukemia virus reverse transcriptase requires metal binding or a short N-terminal extension von Goedken, Eric R., Marqusee, Susan

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Fluorescence Measurements on the E. coli DNA Polymerase Clamp Loader: Implications for Conformational Changes During ATP and Clamp Binding von Goedken, Eric R., Levitus, Marcia, Johnson, Aaron, Bustamante, Carlos, O'Donnell, Mike, Kuriyan, John

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Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2 von Aleksunes, Lauren M., Slitt, Angela L., Maher, Jonathan M., Augustine, Lisa M., Goedken, Michael J., Chan, Jefferson Y., Cherrington, Nathan J., Klaassen, Curtis D., Manautou, José E.

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Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity von Aleksunes, Lauren M, Goedken, Michael J, Rockwell, Cheryl E, Thomale, Juergen, Manautou, Jose E, Klaassen, Curtis D

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Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice? von Rohrer, Philip R, Rudraiah, Swetha, Goedken, Michael J, Manautou, José E

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Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses von Ferreira, Daniel W., Goedken, Michael J., Rommelaere, Samuel, Chasson, Lionel, Galland, Franck, Naquet, Philippe, Manautou, José E.

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Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac von Scialis, Renato J, Csanaky, Iván L, Goedken, Michael J, Manautou, José E

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The feasibility of implementing antibiotic restrictions for fluoroquinolones and cephalosporins: a mixed-methods study across 15 Veterans Health Administration hospitals von Livorsi, Daniel J, Suda, Katie J, Cunningham Goedken, Cassie, Hockett Sherlock, Stacey, Balkenende, Erin, Chasco, Emily E, Scherer, Aaron M, Goto, Michihiko, Perencevich, Eli N, Goetz, Matthew Bidwell, Reisinger, Heather Schacht

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Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds von Ramos, Ashley L., Goedken, Eric R., Frank, Kristine E., Argiriadi, Maria A., Bazzaz, Sana, Bian, Zhiguo, Brown, Jesse T. C., Centrella, Paolo A., Chen, Hui-Ju, Disch, Jeremy S., Donner, Pamela L., Duignan, David B., Gikunju, Diana, Greszler, Stephen N., Guié, Marie-Aude, Habeshian, Sevan, Hartl, Hajnalka E., Hein, Christopher D., Hutchins, Charles W., Jetson, Rachael, Keefe, Anthony D., Khan, Hasan, Li, Huan-Qiu, Olszewski, Allison, Ortiz Cardona, Benjamin J., Osuma, Augustine, Panchal, Sanjay C., Phelan, Ryan, Qiu, Wei, Shotwell, J. Brad, Shrestha, Anurupa, Srikumaran, Myron, Su, Zhi, Sun, Chaohong, Upadhyay, Anup K., Wood, Michael D., Wu, Haihong, Zhang, Ruijie, Zhang, Ying, Zhao, Gang, Zhu, Haizhong, Webster, Matthew P.

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Environmental service workers as potential designers of infection control policy in long-term care settings von Van Tiem, Jennifer M., Friberg, Julia E., Cunningham Goedken, Cassie, Pineles, Lisa, Schacht Reisinger, Heather, Morgan, Daniel J., Solimeo, Samantha L.

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