Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance von Martirosyan, Anna, Clendening, James W, Goard, Carolyn A, Penn, Linda Z

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AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress von Sriskanthadevan, Shrivani, Jeyaraju, Danny V., Chung, Timothy E., Prabha, Swayam, Xu, Wei, Skrtic, Marko, Jhas, Bozhena, Hurren, Rose, Gronda, Marcela, Wang, Xiaoming, Jitkova, Yulia, Sukhai, Mahadeo A., Lin, Feng-Hsu, Maclean, Neil, Laister, Rob, Goard, Carolyn A., Mullen, Peter J., Xie, Stephanie, Penn, Linda Z., Rogers, Ian M., Dick, John E., Minden, Mark D., Schimmer, Aaron D.

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A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity von Jitkova, Yulia, Gronda, Marcela, Hurren, Rose, Wang, Xiaoming, Goard, Carolyn A, Jhas, Bozhena, Schimmer, Aaron D

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Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells von Xu, G Wei, Toth, Julia I, da Silva, Sara R, Paiva, Stacey-Lynn, Lukkarila, Julie L, Hurren, Rose, Maclean, Neil, Sukhai, Mahadeo A, Bhattacharjee, Rabindra N, Goard, Carolyn A, Medeiros, Bruno, Gunning, Patrick T, Dhe-Paganon, Sirano, Petroski, Matthew D, Schimmer, Aaron D

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A multicenter phase I/II study of obatoclax mesylate administered as a 3- or 24-hour infusion in older patients with previously untreated acute myeloid leukemia von Schimmer, Aaron D, Raza, Azra, Carter, Thomas H, Claxton, David, Erba, Harry, DeAngelo, Daniel J, Tallman, Martin S, Goard, Carolyn, Borthakur, Gautam

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Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death von Pandyra, Aleksandra A, Mullen, Peter J, Goard, Carolyn A, Ericson, Elke, Sharma, Piyush, Kalkat, Manpreet, Yu, Rosemary, Pong, Janice T, Brown, Kevin R, Hart, Traver, Gebbia, Marinella, Lang, Karl S, Giaever, Guri, Nislow, Corey, Moffat, Jason, Penn, Linda Z

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Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells von Goard, Carolyn A., Chan-Seng-Yue, Michelle, Mullen, Peter J., Quiroga, Ariel D., Wasylishen, Amanda R., Clendening, James W., Sendorek, Dorota H. S., Haider, Syed, Lehner, Richard, Boutros, Paul C., Penn, Linda Z.

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Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies von Minden, Mark D., Hogge, Donna E., Weir, Scott J., Kasper, Jim, Webster, Debra A., Patton, Lavonne, Jitkova, Yulia, Hurren, Rose, Gronda, Marcela, Goard, Carolyn A., Rajewski, Lian G., Haslam, John L., Heppert, Kathleen E., Schorno, Kevin, Chang, Hong, Brandwein, Joseph M., Gupta, Vikas, Schuh, Andre C., Trudel, Suzanne, Yee, Karen W. L., Reed, Gregory A., Schimmer, Aaron D.

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Differential interactions between statins and P‐glycoprotein: Implications for exploiting statins as anticancer agents von Goard, Carolyn A., Mather, Richard G., Vinepal, Balpreet, Clendening, James W., Martirosyan, Anna, Boutros, Paul C., Sharom, Frances J., Penn, Linda Z.

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An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies von Goard, Carolyn A, Schimmer, Aaron D

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Expression of RBM5-related factors in primary breast tissue von Rintala-Maki, Nina D., Goard, Carolyn A., Langdon, Colleen E., Wall, Vanessa E., Traulsen, Kathryn E.A., Morin, Cory D., Bonin, Michel, Sutherland, Leslie C.

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Abstract 3543: Targeting the metabolic mevalonate pathway with statins as anti-breast cancer agents von Leeuwen, Jenna van, Pandyra, Aleksandra, Goard, Carolyn, Mullen, Peter J., Yu, Rosemary, Penn, Linda Z.

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A consolidated catalogue and graphical annotation of dbSNP polymorphisms in the human tissue kallikrein ( KLK) locus von Goard, Carolyn A., Bromberg, Irvin L., Elliott, Marc B., Diamandis, Eleftherios P.

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The apoptosis modulator and tumour suppressor protein RBM5 is a phosphoprotein von Shu, Yanjun, Rintala-Maki, Nina D., Wall, Vanessa E., Wang, Ke, Goard, Carolyn A., Langdon, Colleen E., Sutherland, Leslie C.

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Abstract PR12: A genome-wide shRNA screen reveals that inhibiting kinases potentiates the anti-breast cancer activity of fluvastatin von Pong, Janice, Pandyra, Aleksandra, Goard, Carolyn, Ericson, Elke, Brown, Kevin, Ylanko, Jarkko, Andrews, David, Nislow, Corey, Moffat, Jason, Penn, Linda

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Abstract C165: Breast cancer, statins, and 3-D cell culture von Mullen, Peter J., Goard, Carolyn A., Wasylishen, Amanda R., Pandyra, Aleksandra, Penn, Linda Z.

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Mutations in UBA3 Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Human Leukemic Cells von Xu, G. Wei, Toth, Julia I, da Silva, Sara R, Paiva, Stacey-Lynn, Lukkarila, Julie L, Hurren, Rose, Maclean, Neil, Sukhai, Mahadeo A, Bhattacharjee, Rabindra N, Goard, Carolyn A, Gunning, Patrick T, Dhe-Paganon, Sirano, Petroski, Matthew D, Schimmer, Aaron D

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Identifying molecular features that distinguish fluvastatinsensitive breast tumor cells von Goard, Carolyn A, Chan-Seng-Yue, Michelle, Mullen, Peter J, Quiroga, Ariel D, Wasylishen, Amanda R, Clendening, James W, Sendorek, Dorota H.S, Haider, Syed, Lehner, Richard, Boutros, Paul C, Penn, Linda Z

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FV-162 Is a Novel Orally Bioavailable Proteasome Inhibitor With Improved Pharmacokinetics That Displays Preclinical Efficacy In Vitro and In Vivo von Wang, Zezhou, Dove, Peter, Wang, Xiaoming, Goard, Carolyn A., Li, Zhihua, Nachman, Alex, Oh, Yoonsun Jenny, Hurren, Rose, Ruschak, Amy, Climie, Shane, O'Neill, David, Press, Barry, Griffin, Carly, Undzys, Elijus, Aman, Ahmed, Al-awar, Rima, Kay, Lewis, Trudel, Suzanne, Slassi, Malik, Schimmer, Aaron

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Mutations In UBA3 Confer Resistance To The NEDD8-Activating Enzyme Inhibitor MLN4924 In Human Leukemic Cells von Xu, G. Wei, Toth, Julia I., da Silva, Sara R., Paiva, Stacey-Lynn, Lukkarila, Julie L., Hurren, Rose, Maclean, Neil, Sukhai, Mahadeo A., Bhattacharjee, Rabindra N., Goard, Carolyn A., Medeiros, Bruno C, Gunning, Patrick T., Dhe-Paganon, Sirano, Petroski, Matthew D., Schimmer, Aaron

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