Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice von Vincent, Jessica, Adura, Carolina, Gao, Pu, Luz, Antonio, Lama, Lodoe, Asano, Yasutomi, Okamoto, Rei, Imaeda, Toshihiro, Aida, Jumpei, Rothamel, Katherine, Gogakos, Tasos, Steinberg, Joshua, Reasoner, Seth, Aso, Kazuyoshi, Tuschl, Thomas, Patel, Dinshaw J., Glickman, J. Fraser, Ascano, Manuel

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Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression von Lama, Lodoe, Adura, Carolina, Xie, Wei, Tomita, Daisuke, Kamei, Taku, Kuryavyi, Vitaly, Gogakos, Tasos, Steinberg, Joshua I., Miller, Michael, Ramos-Espiritu, Lavoisier, Asano, Yasutomi, Hashizume, Shogo, Aida, Jumpei, Imaeda, Toshihiro, Okamoto, Rei, Jennings, Andy J., Michino, Mayako, Kuroita, Takanobu, Stamford, Andrew, Gao, Pu, Meinke, Peter, Glickman, J. Fraser, Patel, Dinshaw J., Tuschl, Thomas

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Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia von Minuesa, Gerard, Albanese, Steven K., Xie, Wei, Kazansky, Yaniv, Worroll, Daniel, Chow, Arthur, Schurer, Alexandra, Park, Sun-Mi, Rotsides, Christina Z., Taggart, James, Rizzi, Andrea, Naden, Levi N., Chou, Timothy, Gourkanti, Saroj, Cappel, Daniel, Passarelli, Maria C., Fairchild, Lauren, Adura, Carolina, Glickman, J. Fraser, Schulman, Jessica, Famulare, Christopher, Patel, Minal, Eibl, Joseph K., Ross, Gregory M., Bhattacharya, Shibani, Tan, Derek S., Leslie, Christina S., Beuming, Thijs, Patel, Dinshaw J., Goldgur, Yehuda, Chodera, John D., Kharas, Michael G.

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Small-Molecule Agonists of Ae. aegypti Neuropeptide Y Receptor Block Mosquito Biting von Duvall, Laura B., Ramos-Espiritu, Lavoisier, Barsoum, Kyrollos E., Glickman, J. Fraser, Vosshall, Leslie B.

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An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance von Hosfelt, Jordan, Richards, Aweon, Zheng, Meng, Adura, Carolina, Nelson, Brock, Yang, Amy, Fay, Allison, Resager, William, Ueberheide, Beatrix, Glickman, J. Fraser, Lupoli, Tania J.

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A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice von Ahn, Hyung Jin, Glickman, J Fraser, Poon, Ka Lai, Zamolodchikov, Daria, Jno-Charles, Odella C, Norris, Erin H, Strickland, Sidney

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Alzheimer's disease peptide β-amyloid interacts with fibrinogen and induces its oligomerization von Ahn, Hyung Jin, Zamolodchikov, Daria, Cortes-Canteli, Marta, Norris, Erin H., Glickman, J. Fraser, Strickland, Sidney, Cerami, Anthony

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MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo von Fontan, Lorena, Yang, Chenghua, Kabaleeswaran, Venkataraman, Volpon, Laurent, Osborne, Michael J., Beltran, Elena, Garcia, Monica, Cerchietti, Leandro, Shaknovich, Rita, Yang, Shao Ning, Fang, Fang, Gascoyne, Randy D., Martinez-Climent, Jose Angel, Glickman, J. Fraser, Borden, Katherine, Wu, Hao, Melnick, Ari

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Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs von Lavin, Richard C, Johnson, Calvin, Ahn, Yong-Mo, Kremiller, Kyle M, Sherwood, Matthew, Patel, Jimmy S, Pan, Yan, Russo, Riccardo, MacGilvary, Nathan J, Giacalone, David, Kevorkian, Yuzo L, Zimmerman, Matthew D, Glickman, J. Fraser, Freundlich, Joel S, Tan, Shumin

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Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials von Gold, Ben, Pingle, Maneesh, Brickner, Steven J, Shah, Nilesh, Roberts, Julia, Rundell, Mark, Bracken, W. Clay, Warrier, Thulasi, Somersan, Selin, Venugopal, Aditya, Darby, Crystal, Jiang, Xiuju, Warren, J. David, Fernandez, Joseph, Ouerfelli, Ouathek, Nuermberger, Eric L, Cunningham-Bussel, Amy, Rath, Poonam, Chidawanyika, Tamutenda, Deng, Haiteng, Realubit, Ronald, Glickman, J. Fraser, Nathan, Carl F

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Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase von Ramos-Espiritu, Lavoisier, Kleinboelting, Silke, Navarrete, Felipe A, Alvau, Antonio, Visconti, Pablo E, Valsecchi, Federica, Starkov, Anatoly, Manfredi, Giovanni, Buck, Hannes, Adura, Carolina, Zippin, Jonathan H, van den Heuvel, Joop, Glickman, J Fraser, Steegborn, Clemens, Levin, Lonny R, Buck, Jochen

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Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation von Xie, Wei, Lama, Lodoe, Adura, Carolina, Tomita, Daisuke, Glickman, J. Fraser, Tuschl, Thomas, Patel, Dinshaw J.

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Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery von Jahnke, Wolfgang, Rondeau, Jean-Michel, Cotesta, Simona, Marzinzik, Andreas, Pellé, Xavier, Geiser, Martin, Strauss, André, Götte, Marjo, Bitsch, Francis, Hemmig, René, Henry, Chrystèle, Lehmann, Sylvie, Glickman, J Fraser, Roddy, Thomas P, Stout, Steven J, Green, Jonathan R

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Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice von Vincent, Jessica, Adura, Carolina, Gao, Pu, Luz, Antonio, Lama, Lodoe, Asano, Yasutomi, Okamoto, Rei, Imaeda, Toshihiro, Aida, Jumpei, Rothamel, Katherine, Gogakos, Tasos, Steinberg, Joshua, Reasoner, Seth, Aso, Kazuyoshi, Tuschl, Thomas, Patel, Dinshaw J., Glickman, J. Fraser, Ascano, Manuel

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High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease von Krumm, Christopher S, Landzberg, Renée S, Ramos-Espiritu, Lavoisier, Adura, Carolina, Liu, Xu, Acuna, Mariana, Xie, Yang, Xu, Xu, Tillman, Matthew C, Li, Yingxia, Glickman, J Fraser, Ortlund, Eric A, Ginn, John D, Cohen, David E

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Orally Bioavailable Isothioureas Block Function of the Chemokine Receptor CXCR4 In Vitro and In Vivo von Thoma, Gebhard, Streiff, Markus B, Kovarik, Jiri, Glickman, Fraser, Wagner, Trixie, Beerli, Christian, Zerwes, Hans-Günter

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Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling von Petrova, Elissaveta, Rios-Esteves, Jessica, Ouerfelli, Ouathek, Glickman, J Fraser, Resh, Marilyn D

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Simulating Henipavirus Multicycle Replication in a Screening Assay Leads to Identification of a Promising Candidate for Therapy von POROTTO, Matteo, OREFICE, Gianmarco, YOKOYAMA, Christine C, MUNGALL, Bruce A, REALUBIT, Ronald, SGANGA, Michael L, ALJOFAN, Mohamad, WHITT, Michael, GLICKMAN, Fraser, MOSCONA, Anne

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N-Sulfonylanthranilic Acid Derivatives as Allosteric Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase von Yin, Zheng, Chen, Yen-Liang, Kondreddi, Ravinder Reddy, Chan, Wai Ling, Wang, Gang, Ng, Ru Hui, Lim, Joanne Y. H, Lee, Wan Yen, Jeyaraj, Duraiswamy A, Niyomrattanakit, Pornwaratt, Wen, Daying, Chao, Alex, Glickman, J. Fraser, Voshol, Hans, Mueller, Dieter, Spanka, Carsten, Dressler, Sigmar, Nilar, Shahul, Vasudevan, Subhash G, Shi, Pei-Yong, Keller, Thomas H

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Arabinose- and xylose-modified analogs of 2′,3′-cGAMP act as STING agonists von Xie, Wei, Lama, Lodoe, Yang, Xuejing, Kuryavyi, Vitaly, Bhattacharya, Shibani, Nudelman, Ilona, Yang, Guangli, Ouerfelli, Ouathek, Glickman, J. Fraser, Jones, Roger A., Tuschl, Thomas, Patel, Dinshaw J.

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