Insights into dynein motor domain function from a 3.3-Å crystal structure von Schmidt, Helgo, Gleave, Emma S, Carter, Andrew P

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Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis von Zhao, Gengjing, Gleave, Emma S, Lamers, Meindert Hugo

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A structural analysis of the AAA+ domains in Saccharomyces cerevisiae cytoplasmic dynein von Gleave, Emma S., Schmidt, Helgo, Carter, Andrew P.

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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration von Kettle, Jason G, Bagal, Sharan K, Barratt, Derek, Bodnarchuk, Michael S, Boyd, Scott, Braybrooke, Erin, Breed, Jason, Cassar, Doyle J, Cosulich, Sabina, Davies, Michael, Davies, Nichola L, Deng, Chao, Eatherton, Andrew, Evans, Laura, Feron, Lyman J, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Cortés González, Miguel A, Guerot, Carine, Haider, Afreen, Harlfinger, Stephanie, Howells, Rachel, Jackson, Anne, Johnström, Peter, Kemmitt, Paul D, Koers, Alex, Kondrashov, Mikhail, Lamont, Gillian M, Lamont, Scott, Lewis, Hilary J, Liu, Libin, Mylrea, Megan, Nash, Samuel, Niedbala, Michael J, Peter, Alison, Phillips, Christopher, Pike, Kurt, Raubo, Piotr, Robb, Graeme R, Ross, Sarah, Sanders, Matthew G, Schou, Magnus, Simpson, Iain, Steward, Oliver

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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration von Kettle, Jason G., Bagal, Sharan K., Barratt, Derek, Bodnarchuk, Michael S., Boyd, Scott, Braybrooke, Erin, Breed, Jason, Cassar, Doyle J., Cosulich, Sabina, Davies, Michael, Davies, Nichola L., Deng, Chao, Eatherton, Andrew, Evans, Laura, Feron, Lyman J., Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Cortés González, Miguel A., Guerot, Carine, Haider, Afreen, Harlfinger, Stephanie, Howells, Rachel, Jackson, Anne, Johnström, Peter, Kemmitt, Paul D., Koers, Alex, Kondrashov, Mikhail, Lamont, Gillian M., Lamont, Scott, Lewis, Hilary J., Liu, Libin, Mylrea, Megan, Nash, Samuel, Niedbala, Michael J., Peter, Alison, Phillips, Christopher, Pike, Kurt, Raubo, Piotr, Robb, Graeme R., Ross, Sarah, Sanders, Matthew G., Schou, Magnus, Simpson, Iain, Steward, Oliver

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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C von Kettle, Jason G., Bagal, Sharan K., Bickerton, Sue, Bodnarchuk, Michael S., Boyd, Scott, Breed, Jason, Carbajo, Rodrigo J., Cassar, Doyle J., Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Davies, Nichola L., Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Hanson, Lyndsey, Harlfinger, Stephanie, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Lamont, Gillian, Lamont, Scott, Lewis, Hilary J., Liu, Libin, Niedbala, Michael J., Phillips, Christopher, Polanski, Radek, Raubo, Piotr, Robb, Graeme, Robinson, David M., Ross, Sarah, Sanders, Matthew G., Tonge, Michael, Whiteley, Rebecca, Wilkinson, Stephen, Yang, Junsheng, Zhang, Wenman

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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C von Kettle, Jason G, Bagal, Sharan K, Bickerton, Sue, Bodnarchuk, Michael S, Boyd, Scott, Breed, Jason, Carbajo, Rodrigo J, Cassar, Doyle J, Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Davies, Nichola L, Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Hanson, Lyndsey, Harlfinger, Stephanie, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Lamont, Gillian, Lamont, Scott, Lewis, Hilary J, Liu, Libin, Niedbala, Michael J, Phillips, Christopher, Polanski, Radek, Raubo, Piotr, Robb, Graeme, Robinson, David M, Ross, Sarah, Sanders, Matthew G, Tonge, Michael, Whiteley, Rebecca, Wilkinson, Stephen, Yang, Junsheng, Zhang, Wenman

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High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS von Ismail, Mohamed, Davies, Gareth, Sproat, Graham, Monteverde, Tiziana, Tart, Jonathan, Acebrón-García-de-Eulate, Marta, Gohlke, Andrea, Hancock, David, Adhikari, Santosh, Stefanovic-Barrett, Sandra, Smith, David M, Flemington, Vikki, Gleave-Hanford, Emma S., Holdgate, Geoffrey A., Kettle, Jason G., Downward, Julian

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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS G12C von Kettle, Jason G, Bagal, Sharan K, Bickerton, Sue, Bodnarchuk, Michael S, Breed, Jason, Carbajo, Rodrigo J, Cassar, Doyle J, Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Harlfinger, Stephanie, Hanson, Lyndsey, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Kingston, Jennifer K, Lamont, Scott, Lewis, Hilary J, Li, Songlei, Liu, Libin, Ogg, Derek, Phillips, Christopher, Polanski, Radek, Robb, Graeme, Robinson, David, Ross, Sarah, Smith, James M, Tonge, Michael, Whiteley, Rebecca, Yang, Junsheng, Zhang, Longfei, Zhao, Xiliang

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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C von Kettle, Jason G, Bagal, Sharan K, Bickerton, Sue, Bodnarchuk, Michael S, Breed, Jason, Carbajo, Rodrigo J, Cassar, Doyle J, Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Harlfinger, Stephanie, Hanson, Lyndsey, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Kingston, Jennifer K, Lamont, Scott, Lewis, Hilary J, Li, Songlei, Liu, Libin, Ogg, Derek, Phillips, Christopher, Polanski, Radek, Robb, Graeme, Robinson, David, Ross, Sarah, Smith, James M, Tonge, Michael, Whiteley, Rebecca, Yang, Junsheng, Zhang, Longfei, Zhao, Xiliang

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Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold von Castells-Graells, Roger, Meador, Kyle, Arbing, Mark A, Sawaya, Michael R, Gee, Morgan, Cascio, Duilio, Gleave, Emma, Debreczeni, Judit É, Breed, Jason, Leopold, Karoline, Patel, Ankoor, Jahagirdar, Dushyant, Lyons, Bronwyn, Subramaniam, Sriram, Phillips, Chris, Yeates, Todd O

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Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold von Castells-Graells, Roger, Meador, Kyle, Arbing, Mark A., Sawaya, Michael R., Gee, Morgan, Cascio, Duilio, Gleave, Emma, Debreczeni, Judit É., Breed, Jason, Leopold, Karoline, Patel, Ankoor, Jahagirdar, Dushyant, Lyons, Bronwyn, Subramaniam, Sriram, Phillips, Chris, Yeates, Todd O.

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Subcortical brain structure and APOE genotype: An analysis of 43,000 participants from the UK Biobank von Ching, Christopher RK, Thomopoulos, Sophia I, Santhalingam, Vigneshwaran, Gleave, Emma J, Zhu, Alyssa H, Islam, Tasfiya, Abaryan, Zvart, Jahanshad, Neda, Thompson, Paul M

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A Systematic Review of the Relationship Between Traumatic Brain Injury and Disruptions in Heart Rate Variability von Talbert, Leah D., Kaelberer, Zoey, Gleave, Emma, Driggs, Annie, Driggs, Ammon S., Baldwin, Scott A., Steffen, Patrick R., Larson, Michael J.

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Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer von Locke, Jennifer A, Guns, Emma S, Lubik, Amy A, Adomat, Hans H, Hendy, Stephen C, Wood, Catherine A, Ettinger, Susan L, Gleave, Martin E, Nelson, Colleen C

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Reproducibility and efficiency of serum-derived exosome extraction methods von Caradec, Josselin, Kharmate, Geetanjali, Hosseini-Beheshti, Elham, Adomat, Hans, Gleave, Martin, Guns, Emma

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Anticancer activity of a novel selective CYP17A1 inhibitor in preclinical models of castrate-resistant prostate cancer von Toren, Paul J, Kim, Soojin, Pham, Steven, Mangalji, Azzra, Adomat, Hans, Guns, Emma S Tomlinson, Zoubeidi, Amina, Moore, William, Gleave, Martin E

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Steroidogenesis in Peripheral and Transition Zones of Human Prostate Cancer Tissue von Deb, Subrata, Chin, Mei Yieng, Pham, Steven, Adomat, Hans, Hurtado-Coll, Antonio, Gleave, Martin E, Tomlinson Guns, Emma S

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Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles von Minciacchi, Valentina R, You, Sungyong, Spinelli, Cristiana, Morley, Samantha, Zandian, Mandana, Aspuria, Paul-Joseph, Cavallini, Lorenzo, Ciardiello, Chiara, Reis Sobreiro, Mariana, Morello, Matteo, Kharmate, Geetanjali, Jang, Su Chul, Kim, Dae-Kyum, Hosseini-Beheshti, Elham, Tomlinson Guns, Emma, Gleave, Martin, Gho, Yong Song, Mathivanan, Suresh, Yang, Wei, Freeman, Michael R, Di Vizio, Dolores

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Characterization of Precursor-Dependent Steroidogenesis in Human Prostate Cancer Models von Deb, Subrata, Pham, Steven, Ming, Dong-Sheng, Chin, Mei Yieng, Adomat, Hans, Hurtado-Coll, Antonio, Gleave, Martin E, Guns, Emma S Tomlinson

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