The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination von Schipani, Fabrizio, Manerba, Marcella, Marotta, Roberto, Poppi, Laura, Gennari, Arianna, Rinaldi, Francesco, Armirotti, Andrea, Farabegoli, Fulvia, Roberti, Marinella, Di Stefano, Giuseppina, Rocchia, Walter, Girotto, Stefania, Tirelli, Nicola, Cavalli, Andrea

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Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives von Barbieri, Federica, Bosio, Alessia Graziana, Pattarozzi, Alessandra, Tonelli, Michele, Bajetto, Adriana, Verduci, Ivan, Cianci, Francesca, Cannavale, Gaetano, Palloni, Luca M G, Francesconi, Valeria, Thellung, Stefano, Fiaschi, Pietro, Mazzetti, Samanta, Schenone, Silvia, Balboni, Beatrice, Girotto, Stefania, Malatesta, Paolo, Daga, Antonio, Zona, Gianluigi, Mazzanti, Michele, Florio, Tullio

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SOD1 and amyotrophic lateral sclerosis: mutations and oligomerization von Banci, Lucia, Bertini, Ivano, Boca, Mirela, Girotto, Stefania, Martinelli, Manuele, Valentine, Joan Selverstone, Vieru, Miguela

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Structure-based approaches in synthetic lethality strategies von Rinaldi, Francesco, Girotto, Stefania

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An integrative structural study of the human full-length RAD52 at 2.2 Å resolution von Balboni, Beatrice, Marotta, Roberto, Rinaldi, Francesco, Milordini, Giulia, Varignani, Giulia, Girotto, Stefania, Cavalli, Andrea

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Structural and Dynamic Aspects Related to Oligomerization of Apo SOD1 and Its Mutants von Banci, Lucia, Bertini, Ivano, Boca, Mirela, Calderone, Vito, Cantini, Francesca, Girotto, Stefania, Vieru, Miguela, Gronenborn, Angela M.

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Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: A possible general mechanism for familial ALS von Banci, Lucia, Bertini, Ivano, Durazo, Armando, Girotto, Stefania, Gralla, Edith Butler, Martinelli, Manuele, Valentine, Joan Selverstone, Vieru, Miguela, Whitelegge, Julian P

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Lid domain plasticity and lipid flexibility modulate enzyme specificity in human monoacylglycerol lipase von Riccardi, Laura, Arencibia, Jose M., Bono, Luca, Armirotti, Andrea, Girotto, Stefania, De Vivo, Marco

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Dopamine-derived Quinones Affect the Structure of the Redox Sensor DJ-1 through Modifications at Cys-106 and Cys-53 von Girotto, Stefania, Sturlese, Mattia, Bellanda, Massimo, Tessari, Isabella, Cappellini, Rekha, Bisaglia, Marco, Bubacco, Luigi, Mammi, Stefano

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Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets von Palermo, Giulia, Bauer, Inga, Campomanes, Pablo, Cavalli, Andrea, Armirotti, Andrea, Girotto, Stefania, Rothlisberger, Ursula, De Vivo, Marco

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Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells von Ortega, Jose Antonio, Arencibia, Jose M, La Sala, Giuseppina, Borgogno, Marco, Bauer, Inga, Bono, Luca, Braccia, Clarissa, Armirotti, Andrea, Girotto, Stefania, Ganesan, Anand, De Vivo, Marco

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GSK-3β Allosteric Inhibition: A Dead End or a New Pharmacological Frontier? von Balboni, Beatrice, Masi, Mirco, Rocchia, Walter, Girotto, Stefania, Cavalli, Andrea

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Radical Sites in Mycobacterium tuberculosis KatG Identified Using Electron Paramagnetic Resonance Spectroscopy, the Three-dimensional Crystal Structure, and Electron Transfer Coupl... von Ranguelova, Kalina, Girotto, Stefania, Gerfen, Gary J., Yu, Shengwei, Suarez, Javier, Metlitsky, Leonid, Magliozzo, Richard S.

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Rapid Formation of Compound II and a Tyrosyl Radical in the Y229F Mutant of Mycobacterium tuberculosis Catalase-peroxidase Disrupts Catalase but Not Peroxidase Function von Yu, Shengwei, Girotto, Stefania, Zhao, Xiangbo, Magliozzo, Richard S.

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Investigating Drug–Target Residence Time in Kinases through Enhanced Sampling Simulations von Gobbo, Dorothea, Piretti, Valentina, Di Martino, Rita Maria Concetta, Tripathi, Shailesh Kumar, Giabbai, Barbara, Storici, Paola, Demitri, Nicola, Girotto, Stefania, Decherchi, Sergio, Cavalli, Andrea

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Novel Insights into RAD52's Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies von Balboni, Beatrice, Rinaldi, Francesco, Previtali, Viola, Ciamarone, Andrea, Girotto, Stefania, Cavalli, Andrea

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Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib von Bagnolini, Greta, Milano, Domenico, Manerba, Marcella, Schipani, Fabrizio, Ortega, Jose Antonio, Gioia, Dario, Falchi, Federico, Balboni, Andrea, Farabegoli, Fulvia, De Franco, Francesca, Robertson, Janet, Pellicciari, Roberto, Pallavicini, Isabella, Peri, Sebastiano, Minucci, Saverio, Girotto, Stefania, Di Stefano, Giuseppina, Roberti, Marinella, Cavalli, Andrea

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Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer von Rinaldi, Francesco, Schipani, Fabrizio, Balboni, Beatrice, Catalano, Federico, Marotta, Roberto, Myers, Samuel H., Previtali, Viola, Veronesi, Marina, Scietti, Luigi, Cecatiello, Valentina, Pasqualato, Sebastiano, Ortega, Jose Antonio, Girotto, Stefania, Cavalli, Andrea

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Analysis of Heme Structural Heterogeneity in Mycobacterium tuberculosis Catalase-Peroxidase (KatG) von Chouchane, Salem, Girotto, Stefania, Kapetanaki, Sofia, Schelvis, Johannes P M, Yu, Shengwei, Magliozzo, Richard S

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Evidence for Radical Formation at Tyr-353 in Mycobacterium tuberculosis Catalase-Peroxidase (KatG) von Zhao, Xiangbo, Girotto, Stefania, Yu, Shengwei, Magliozzo, Richard S.

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