SPARC Promotes Cathepsin B-Mediated Melanoma Invasiveness through a Collagen I/α2β1 Integrin Axis von Girotti, María R., Fernández, Marisol, López, Juan A., Camafeita, Emilio, Fernández, Elmer A., Albar, Juan P., Benedetti, Lorena G., Valacco, María P., Brekken, Rolf A., Podhajcer, Osvaldo L., Llera, Andrea S.

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Pan-Cancer Molecular Patterns and Biological Implications Associated with a Tumor-Specific Molecular Signature von Rocha, Darío, García, Iris A, González Montoro, Aldana, Llera, Andrea, Prato, Laura, Girotti, María R, Soria, Gastón, Fernández, Elmer A

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Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy von Smith, Michael P., Brunton, Holly, Rowling, Emily J., Ferguson, Jennifer, Arozarena, Imanol, Miskolczi, Zsofia, Lee, Jessica L., Girotti, Maria R., Marais, Richard, Levesque, Mitchell P., Dummer, Reinhard, Frederick, Dennie T., Flaherty, Keith T., Cooper, Zachary A., Wargo, Jennifer A., Wellbrock, Claudia

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Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits von Morosi, Luciano G., Cutine, Anabela M., Cagnoni, Alejandro J., Manselle-Cocco, Montana N., Croci, Diego O., Merlo, Joaquín P., Morales, Rosa M., May, María, Pérez-Sáez, Juan M., Girotti, María R., Méndez-Huergo, Santiago P., Pucci, Betiana, Gil, Aníbal H., Huernos, Sergio P., Docena, Guillermo H., Sambuelli, Alicia M., Toscano, Marta A., Rabinovich, Gabriel A., Mariño, Karina V.

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ATP‐dependent modulation and autophosphorylation of rapeseed 2‐Cys peroxiredoxin von Aran, Martin, Caporaletti, Daniel, Senn, Alejandro M., Tellez de Iñon, María T., Girotti, María R., Llera, Andrea S., Wolosiuk, Ricardo A.

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Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma von Girotti, Maria R, Pedersen, Malin, Sanchez-Laorden, Berta, Viros, Amaya, Turajlic, Samra, Niculescu-Duvaz, Dan, Zambon, Alfonso, Sinclair, John, Hayes, Andrew, Gore, Martin, Lorigan, Paul, Springer, Caroline, Larkin, James, Jorgensen, Claus, Marais, Richard

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Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells von Baenke, Franziska, Chaneton, Barbara, Smith, Matthew, Van Den Broek, Niels, Hogan, Kate, Tang, Haoran, Viros, Amaya, Martin, Matthew, Galbraith, Laura, Girotti, Maria R., Dhomen, Nathalie, Gottlieb, Eyal, Marais, Richard

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Liquid biopsy for KRAS, NRAS and BRAF mutation testing in advanced colorectal cancer patients: the Argentinean experience von Güttlein, Leandro, Luca, María R, Esteso, Federico, Fresno, Cristóbal, Mariani, Javier, Otero Pizarro, Mercedes, Brest, Esteban, Starapoli, Solange, Kreimberg, Kevin, Teves, Paula, Mendoza Bertelli, Andrea, R Girotti, María, Salanova, Ruben, O’Connor, Juan M

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Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors von Marusiak, Anna A., Edwards, Zoe C., Hugo, Willy, Trotter, Eleanor W., Girotti, Maria R., Stephenson, Natalie L., Kong, Xiangju, Gartside, Michael G., Fawdar, Shameem, Hudson, Andrew, Breitwieser, Wolfgang, Hayward, Nicholas K., Marais, Richard, Lo, Roger S., Brognard, John

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The multi-reference contrast method: Facilitating set enrichment analysis von Fresno, Cristóbal, Llera, Andrea S, Girotti, María R, Valacco, María P, López, Juan A, Podhajcer, Osvaldo L, Balzarini, Mónica G, Prada, Federico, Fernández, Elmer A

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Improving 2D-DIGE protein expression analysis by two-stage linear mixed models: assessing experimental effects in a melanoma cell study von Ferná, ndez, Elmer A., Girotti, María R., del Olmo, Juan A. López, Llera, Andrea S., Podhajcer, Osvaldo L., Cantet, Rodolfo J. C., Balzarini, Mónica

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Abstract 469: Systematic analysis of circulating tumor DNA in melanoma patients to uncover mechanisms of resistance and disease clonality von Gremel, Gabriela, Lee, Rebecca J., Girotti, Maria R., Garner, Grace, Mandal, Amit K., Wood, Sally, Fusi, Alberto, Valpione, Sara, Serra-Bellver, Patricio, Dhomen, Nathalie, Lorigan, Paul, Marais, Richard

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SPARC Promotes Cathepsin B-Mediated Melanoma Invasiveness through a Collagen I/[alpha]2[beta]1 Integrin Axis von Girotti, María R, Fernández, Marisol, López, Juan A, Camafeita, Emilio, Fernández, Elmer A, Albar, Juan P, Benedetti, Lorena G, Valacco, María P, Brekken, Rolf A, Podhajcer, Osvaldo L, Llera, Andrea S

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Abstract 6548: Bioinformatic characterization of dendritic and T cell subpopulations in the tumor microenvironment across different cancer types by single-cell RNA-Seq analysis von Mahmoud, Yamil D., Rego, Natalia, Vilarino, Marcela, Veigas, Florencia, Girotti, Maria R., Saez, Juan M. Perez, Rabinovich, Gabriel A., Hill, Marcelo

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Abstract 2261: Deciphering cross-resistance mechanisms associated to targeted therapies and immunotherapy in BRAFmutmelanoma: The role of tumor-associated macrophages and galectin-... von Veigas, Florencia, Mahmoud, Yamil Damian, Merlo, Joaquin P., Cocco, Montana Manselle, Massaro, Mora, Gatto, Sabrina, Morales, Rosa, Girotti, Maria R., Perez-Saez, Juan M., Rabinovich, Gabriel A.

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Inhibiting drivers of non-mutational drug tolerance is a salvage strategy for targeted melanoma therapy von Smith, Michael P, Brunton, Holly, Rowling, Emily J, Ferguson, Jennifer, Arozarena, Imanol, Miskolczi, Zsofia, Lee, Jessica L, Girotti, Maria R, Marais, Richard, Levesque, Mitchell P, Dummer, Reinhard, Frederick, Dennie T, Flaherty, Keith T, Cooper, Zachary A, Wargo, Jennifer A, Wellbrock, Claudia

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Abstract 2432: A technology platform for personalized medicine in melanoma von Girotti, Maria R., Rothwell, Dominic, Viros, Amaya, Mandal, Amit Kumar, Lim, Kok Haw J., Gremel, Gabriela, Furney, Simon, Pedersen, Malin, Rogan, Jane, Swan, Jacqueline, Fusi, Alberto, Brady, Ged, Lorigan, Paul, Dive, Caroline, Marais, Richard

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Abstract 470: Application of sequencing, liquid biopsies and patient derived xenografts for personalized medicine in melanoma von Girotti, Maria R., Gremel, Gabriela, Lee, Rebecca, Galvani, Elena, Rothwell, Dominic, Viros, Amaya, Mandal, Amit Kumar, Lim, Kok Haw Jonathan, Saturno, Grazia, Furney, Simon J, Baenke, Franziska, Pedersen, Malin, Rogan, Jane, Swan, Jacqueline, Smith, Matthew, Fusi, Alberto, Oudit, Deemesh, Dhomen, Nathalie, Brady, Ged, Dive, Caroline, Marais, Richard

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Abstract 3704: Novel panRAF inhibitors active in melanomas that are resistant to BRAF-selective, or BRAF-selective/MEK inhibitor combinations von Girotti, Maria R., Lopes, Filipa, Preece, Natasha, Niculescu-Duvaz, Dan, Zambon, Alfonso, Davies, Lawrence, Whittaker, Steven, Saturno, Grazia, Viros, Amaya, Pedersen, Malin, Suijkerbuijk, Bart MJM, Menard, Delphine, Mcleary, Robert, Johnson, Louise, Fish, Laura, Ejiama, Sarah, Sanchez-Laorden, Berta, Carragher, Neil, Macleod, Kenneth, Ashton, Garry, Marusiak, Anna, Fusi, Alberto, Brognard, John, Frame, Margaret, Lorigan, Paul, Springer, Caroline J., Marais, Richard

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Abstract 3404: Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma von Girotti, Maria R., Pedersen, Malin, Sanchez-Laorden, Berta, Viros, Amaya, Turajlic, Samra, Niculescu-Duvaz, Dan, Zambon, Alfonso, Sinclair, John, Hayes, Andrew, Gore, Martin, Springer, Caroline, Larkin, James, Jorgensen, Claus, Marais, Richard

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