Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK) von Ott, Gregory R, Cheng, Mangeng, Learn, Keith S, Wagner, Jason, Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew, Mesaros, Eugen F, Ghose, Arup K, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Dobrzanski, Pawel, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin, Huang, Zeqi, Aimone, Lisa D, Bruckheimer, Elizabeth, Anderson, Nathan, Friedman, Jay, Fernandez, Sandra V, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D

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Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2 von Lu, Lily D, Stump, Kristine L, Wallace, Nate H, Dobrzanski, Pawel, Serdikoff, Cynthia, Gingrich, Diane E, Dugan, Benjamin J, Angeles, Thelma S, Albom, Mark S, Mason, Jennifer L, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce A, Seavey, Matthew M

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A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis von Stump, Kristine L, Lu, Lily D, Dobrzanski, Pawel, Serdikoff, Cynthia, Gingrich, Diane E, Dugan, Ben J, Angeles, Thelma S, Albom, Mark S, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce A, Seavey, Matthew M

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Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase von Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew A, Cheng, Mangeng, Quail, Matthew, Lu, Lihui, Wan, Weihua, Albom, Mark S, Angeles, Thelma S, Aimone, Lisa D, Haltiwanger, R. Curtis, Wells-Knecht, Kevin, Ott, Gregory R, Ghose, Arup K, Ator, Mark A, Ruggeri, Bruce, Dorsey, Bruce D

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Advances in the development of kinase inhibitor therapeutics for Alzheimer's disease von Savage, Mary J., Gingrich, Diane E.

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CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers von Cheng, Mangeng, Quail, Matthew R, Gingrich, Diane E, Ott, Gregory R, Lu, Lihui, Wan, Weihua, Albom, Mark S, Angeles, Thelma S, Aimone, Lisa D, Cristofani, Flavio, Machiorlatti, Rodolfo, Abele, Cristina, Ator, Mark A, Dorsey, Bruce D, Inghirami, Giorgio, Ruggeri, Bruce A

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A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779 von Dugan, Benjamin J, Gingrich, Diane E, Mesaros, Eugen F, Milkiewicz, Karen L, Curry, Matthew A, Zulli, Allison L, Dobrzanski, Pawel, Serdikoff, Cynthia, Jan, Mahfuza, Angeles, Thelma S, Albom, Mark S, Mason, Jennifer L, Aimone, Lisa D, Meyer, Sheryl L, Huang, Zeqi, Wells-Knecht, Kevin J, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D

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2,7-Disubstituted-pyrrolo[2,1-f][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitu... von Ott, Gregory R, Wells, Gregory J, Thieu, Tho V, Quail, Matthew R, Lisko, Joseph G, Mesaros, Eugen F, Gingrich, Diane E, Ghose, Arup K, Wan, Weihua, Lu, Lihui, Cheng, Mangeng, Albom, Mark S, Angeles, Thelma S, Huang, Zeqi, Aimone, Lisa D, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D

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Development and Scale-Up of an Optimized Route to the ALK Inhibitor CEP-28122 von Allwein, Shawn P, Roemmele, Renee C, Haley, James J, Mowrey, Dale R, Petrillo, Daniel E, Reif, James J, Gingrich, Diane E, Bakale, Roger P

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2,7-Pyrrolo[2,1- f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation von Weinberg, Linda R., Albom, Mark S., Angeles, Thelma S., Breslin, Henry J., Gingrich, Diane E., Huang, Zeqi, Lisko, Joseph G., Mason, Jennifer L., Milkiewicz, Karen L., Thieu, Tho V., Underiner, Ted L., Wells, Gregory J., Wells-Knecht, Kevin J., Dorsey, Bruce D.

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2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation von Wells-Knecht, Kevin J, Ott, Gregory R, Cheng, Mangeng, Wells, Gregory J, Breslin, Henry J, Gingrich, Diane E, Weinberg, Linda, Mesaros, Eugen F, Huang, Zeqi, Yazdanian, Mehran, Ator, Mark A, Aimone, Lisa D, Zeigler, Kelli, Dorsey, Bruce D

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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases von Zificsak, Craig A., Gingrich, Diane E., Breslin, Henry J., Dunn, Derek D., Milkiewicz, Karen L., Theroff, Jay P., Thieu, Tho V., Underiner, Ted L., Weinberg, Linda R., Aimone, Lisa D., Albom, Mark S., Mason, Jennifer L., Saville, Lisa, Husten, Jean, Angeles, Thelma S., Finn, James P., Jan, Mahfuza, O’Kane, Teresa M., Dobrzanski, Pawel, Dorsey, Bruce D.

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A New Class of Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors:  Structure−Activity Relationships for a Series of 9-Alkoxymethyl-12-(3-hydroxypropyl)i... von Gingrich, Diane E, Reddy, Dandu R, Iqbal, Mohamed A, Singh, Jasbir, Aimone, Lisa D, Angeles, Thelma S, Albom, Mark, Yang, Shi, Ator, Mark A, Meyer, Sheryl L, Robinson, Candy, Ruggeri, Bruce A, Dionne, Craig A, Vaught, Jeffry L, Mallamo, John P, Hudkins, Robert L

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A Novel Preparation of Scalemic N-Methyl-.alpha.-Amino Acids von Dorow, R. L, Gingrich, Diane E

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Synthesis, Modeling, and In Vitro Activity of (3‘S)-epi-K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity von GINGRICH, Diane E., YANG, Shi X., GESSNER, George W., ANGELES, Thelma S., HUDKINS, Robert L.

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Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a von GINGRICH, Diane E, HUDKINS, Robert L

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Synthesis, Modeling, and In Vitro Activity of (3‘S)-e pi-K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity von Gingrich, Diane E, Yang, Shi X, Gessner, George W, Angeles, Thelma S, Hudkins, Robert L

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Abstract 3574: Identification and preclinical characterization of CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase, in lymphoma and no... von Cheng, Mangeng, Quail, Matthew R., Gingrich, Diane E., Ott, Gregory R., Lu, Lihui, Wan, Weihua, Albom, Mark S., Angeles, Thelma S., Aimone, Lisa D., Cristofani, Flavio, Machiorlatti, Rodolfo, Abele, Cristina, Ator, Mark A., Dorsey, Bruce D., Inghirami, Giorgio, Ruggeri, Bruce A.

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composto, e, composição farmacêutica von Allison L. Zulli, James L. Diebold, THEODORE L. UNDERINER, Dandu R. Reddy, MING TAO, Nadine C. Becknell, ROBERT L. HUDKINS, DIANE E. GINGRICH

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composto, composição e uso de um composto von MATTHEW A. CURRY, BRUCE D. DORSEY, EUGEN F. MESAROS, KAREN L. MILKIEWICS, BENJAMIN J. DUGAN, DIANE E. GINGRICH

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