Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2, in patients with... von Naing, Aung, Eder, Joseph P, Piha-Paul, Sarina A, Gimmi, Claude, Hussey, Elizabeth, Zhang, Sen, Hildebrand, Vera, Hosagrahara, Vinayak, Habermehl, Christina, Moisan, Jacques, Papadopoulos, Kyriakos P

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Using thrombocytopenia modeling to investigate the mechanisms underlying platelet depletion induced by pan‐proteasome inhibitors von Lignet, Floriane, Becker, Andreas D., Gimmi, Claude, Rohdich, Felix, El Bawab, Samer

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The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of CH4987655 in Healthy Volunteers: Target Suppression Using a Biomarker von LEE, Lucy, HUIFENG NIU, GOELZER, Petra, DE SCHEPPER, Stefanie, YOSHIMURA, Yashushi, BARRETT, Joanne, ISHIKAWA, Yuji, WEISSGERBER, Georges, PECK, Richard, RUEGER, Ruediger, IGAWA, Yuriko, DEUTSCH, Jonathan, ISHII, Nobuya, SONG MU, SAKAMOTO, Yuuichiro, BUSSE-REID, Rachel, GIMMI, Claude

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Human T-Cell Clonal Anergy is Induced by Antigen Presentation in the Absence of B7 Costimulation von Gimmi, Claude D., Freeman, Gordon J., Gribben, John G., Gray, Gary, Nadler, Lee M.

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Differential Effect on Bone Lesions of Targeting Integrins: Randomized Phase II Trial of Abituzumab in Patients with Metastatic Castration-Resistant Prostate Cancer von Hussain, Maha, Le Moulec, Sylvestre, Gimmi, Claude, Bruns, Rolf, Straub, Josef, Miller, Kurt

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Targeting HER-2/neu with antirat Neu virosomes for cancer therapy von WAELTI, Ernst, WEGMANN, Nina, SCHWANINGER, Ruth, WETTERWALD, Antionette, WINGENFELD, Carsten, ROTHEN-RUTISHAUSER, Barbara, GIMMI, Claude D

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Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells von Gimmi, Claude D, Morrison, Briggs W, Mainprice, Brigitte A, Gribben, John G, Boussiotis, Vassiliki A, Freeman, Gordon J, Lee Park, Suun Young, Watanabe, Michiaki, Gong, JianLin, Hayes, Daniel F, Kufe, Donald W, Nadler, Lee M

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Translational PK/PD Modeling of Tumor Growth Inhibition and Target Inhibition to Support Dose Range Selection of the LMP7 Inhibitor M3258 in Relapsed/Refractory Multiple Myeloma von Lignet, Floriane, Esdar, Christina, Walter-Bausch, Gina, Friese-Hamim, Manja, Stinchi, Sofia, Drouin, Elise, El Bawab, Samer, Becker, Andreas D, Gimmi, Claude, Sanderson, Michael P, Rohdich, Felix

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Abstract CT011: First-in-human Phase I study of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase-1 and tryptophan 2,3-dioxygenase 2, in patients with advanced solid m... von Papadopoulos, Kyriakos, Eder, Paul, Piha-Paul, Sarina A., Gimmi, Claude, Hussey, Elizabeth, Zhang, Sen, Li, Lu, Habermehl, Christina, Naing, Aung

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Virosomes as new carrier system for cancer vaccines von SCHWANINGER, Ruth, WAELTI, Ernst, ZAJAC, Paul, WETTERWALD, Antoinette, MUELLER, Dominique, GIMMI, Claude D

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Quantitative PK/PD Prediction of the Efficacious and Safe Dose Ranges of the LMP7 Inhibitor M3258 for Phase I Application in Relapsed/Refractory Multiple Myeloma Patients von Lignet, Florian, Esdar, Christina, Friese-Hamim, Manja, Becker, Andreas, Drouin, Elise, El Bawab, Samer, Goodstal, Samantha M., Gimmi, Claude, Haselmayer, Phlipp, Jährling, Frank, Sanderson, Michael, Sloot, Willem, Stinchi, Sofia, Victor, Anja, Walter, Gina, Rohdich, Felix

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A First-in-human, Dose-escalation Study of the Methionine Aminopeptidase 2 Inhibitor M8891 in Patients with Advanced Solid Tumors von Carducci, Michael A, Wang, Ding, Habermehl, Christina, Bödding, Matthias, Rohdich, Felix, Lignet, Floriane, Duecker, Klaus, Karpenko, Oleksandr, Pudelko, Linda, Gimmi, Claude, LoRusso, Patricia

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Role of Fas ligand expression in promoting escape from immune rejection in a spontaneous tumor model von Céfai, Daniel, Favre, Luc, Wattendorf, Elise, Marti, Andreas, Jaggi, Rolf, Gimmi, Claude D.

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Abstract C119: Investigation of the anti-angiogenic effects of abituzumab in patients with colorectal or ovarian cancer and liver metastases using dynamic contrast-enhanced magneti... von Tabernero, Josep, Parker, Geoffrey, Clamp, Andrew, Elez, Elena, Mescallado, Nerissa, Dienstmann, Rodrigo, Sauri, Tamara, Hasan, Jurjees, Mateos, Jose J., Bruns, Rolf, Gimmi, Claude, Jayson, Gordon C.

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B-Cell Surface Antigen B7 Provides a Costimulatory Signal That Induces T Cells to Proliferate and Secrete Interleukin 2 von Gimmi, Claude D., Freeman, Gordon J., Gribben, John G., Sugita, Kanji, Freedman, Arnold S., Morimoto, Chikao, Nadler, Lee M.

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Detection by Polymerase Chain Reaction of Residual Cells With the bcl-2 Translocation Is Associated With Increased Risk of Relapse After Autologous Bone Marrow Transplantation for... von Gribben, John G., Neuberg, Donna, Freedman, Arnold S., Gimmi, Claude D., Pesek, Kelly W., Barber, Michael, Saporlto, Laura, Woo, Sunhee D., Coral, Felice, Spector, Neil, Rabinowe, Susan N., Grossbard, Michael L., Ritz, Jerome, Nadler, Lee M.

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Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7 von FREEMAN, G. J, GRAY, G. S, GIMMI, C. D, LOMBARD, D. B, LIANG-JI ZHOU, WHITE, M, FINGEROTH, J. D, GRIBBEN, J. G, NADLER, L. M

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Targeting HER‐2/neu for active‐specific immunotherapy in a mouse model of spontaneous breast cancer von Céfaï, Daniel, Morrison, Briggs W., Sckell, Axel, Favre, Luc, Balli, Marietta, Leunig, Michael, Gimmi, Claude D.

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COMBINATION OF AN ANTI-PD-L1 ANTIBODY AND IDO1 INHIBITOR FOR THE TREATMENT OF CANCER von MOISAN, Jacques, GIMMI, Claude, SHERER, Brian A

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Murine B7 Antigen Provides an Efficient Costimulatory Signal for Activation of Murine T Lymphocytes via the T-Cell Receptor/CD3 Complex von Reiser, Hans, Freeman, Gordon J., Razi-Wolf, Ziba, Gimmi, Claude D., Benacerraf, Baruj, Nadler, Lee M.

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