Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care von Gillooly, Kathleen M, Pulicicchio, Claudine, Pattoli, Mark A, Cheng, Lihong, Skala, Stacey, Heimrich, Elizabeth M, McIntyre, Kim W, Taylor, Tracy L, Kukral, Daniel W, Dudhgaonkar, Shailesh, Nagar, Jignesh, Banas, Dana, Watterson, Scott H, Tino, Joseph A, Fura, Aberra, Burke, James R

Volltext

2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piper... von Das, Jagabandhu, Chen, Ping, Norris, Derek, Padmanabha, Ramesh, Lin, James, Moquin, Robert V, Shen, Zhongqi, Cook, Lynda S, Doweyko, Arthur M, Pitt, Sidney, Pang, Suhong, Shen, Ding Ren, Fang, Qiong, de Fex, Henry F, McIntyre, Kim W, Shuster, David J, Gillooly, Kathleen M, Behnia, Kamelia, Schieven, Gary L, Wityak, John, Barrish, Joel C

Volltext

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinas... von Watterson, Scott H, Liu, Qingjie, Beaudoin Bertrand, Myra, Batt, Douglas G, Li, Ling, Pattoli, Mark A, Skala, Stacey, Cheng, Lihong, Obermeier, Mary T, Moore, Robin, Yang, Zheng, Vickery, Rodney, Elzinga, Paul A, Discenza, Lorell, D’Arienzo, Celia, Gillooly, Kathleen M, Taylor, Tracy L, Pulicicchio, Claudine, Zhang, Yifan, Heimrich, Elizabeth, McIntyre, Kim W, Ruan, Qian, Westhouse, Richard A, Catlett, Ian M, Zheng, Naiyu, Chaudhry, Charu, Dai, Jun, Galella, Michael A, Tebben, Andrew J, Pokross, Matt, Li, Jianqing, Zhao, Rulin, Smith, Daniel, Rampulla, Richard, Allentoff, Alban, Wallace, Michael A, Mathur, Arvind, Salter-Cid, Luisa, Macor, John E, Carter, Percy H, Fura, Aberra, Burke, James R, Tino, Joseph A

Volltext

Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2 von Liu, Chunjian, Lin, James, Langevine, Charles, Smith, Daniel, Li, Jianqing, Tokarski, John S, Khan, Javed, Ruzanov, Max, Strnad, Joann, Zupa-Fernandez, Adriana, Cheng, Lihong, Gillooly, Kathleen M, Shuster, David, Zhang, Yifan, Thankappan, Anil, McIntyre, Kim W, Chaudhry, Charu, Elzinga, Paul A, Chiney, Manoj, Chimalakonda, Anjaneya, Lombardo, Louis J, Macor, John E, Carter, Percy H, Burke, James R, Weinstein, David S

Volltext

Discovery of 6‑Fluoro-5‑(R)‑(3‑(S)‑(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)‑yl)-2-methylphenyl)-2‑(S)‑(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro‑1H‑carbazole-8-carbo... von Watterson, Scott H, De Lucca, George V, Shi, Qing, Langevine, Charles M, Liu, Qingjie, Batt, Douglas G, Beaudoin Bertrand, Myra, Gong, Hua, Dai, Jun, Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Wang, Chunlei, Zhang, Yingru, Traeger, Sarah C, Pattoli, Mark A, Skala, Stacey, Cheng, Lihong, Obermeier, Mary T, Vickery, Rodney, Discenza, Lorell N, D’Arienzo, Celia J, Zhang, Yifan, Heimrich, Elizabeth, Gillooly, Kathleen M, Taylor, Tracy L, Pulicicchio, Claudine, McIntyre, Kim W, Galella, Michael A, Tebben, Andy J, Muckelbauer, Jodi K, Chang, ChiehYing, Rampulla, Richard, Mathur, Arvind, Salter-Cid, Luisa, Barrish, Joel C, Carter, Percy H, Fura, Aberra, Burke, James R, Tino, Joseph A

Volltext

5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase von Liu, Chunjian, Wrobleski, Stephen T, Lin, James, Ahmed, Gulzar, Metzger, Axel, Wityak, John, Gillooly, Kathleen M, Shuster, David J, McIntyre, Kim W, Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary F, Zhang, Hongjian, Doweyko, Arthur M, Diller, David, Henderson, Ian, Barrish, Joel C, Dodd, John H, Schieven, Gary L, Leftheris, Katerina

Volltext

A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice von Kang, Liya, McIntyre, Kim W., Gillooly, Kathleen M., Yang, Yifan, Haycock, John, Roberts, Stephen, Khanna, Ashish, Herpin, Timothy F., Yu, Guixue, Wu, Ximao, Morton, George C., Tuerdi, Huji, Koplowitz, Barry, Walker, Stephen G., Wardwell‐Swanson, Judy, Macor, John E., Lawrence, R. Michael, Carlson, Kenneth E.

Volltext

Reduced incidence and severity of collagen‐induced arthritis in interleukin‐12‐deficient mice von McIntyre, Kim W., Shuster, David J., Gillooly, Kathleen M., Warrier, Rajeev R., Connaughton, Suzanne E., Hall, Leroy B., Arp, Lawrence H., Gately, Maurice K., Magram, Jeanne

Volltext

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3‑Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders von Liu, Qingjie, Shi, Qing, Marcoux, David, Batt, Douglas G, Cornelius, Lyndon, Qin, Lan-Ying, Ruan, Zheming, Neels, James, Beaudoin-Bertrand, Myra, Srivastava, Anurag S, Li, Ling, Cherney, Robert J, Gong, Hua, Watterson, Scott H, Weigelt, Carolyn, Gillooly, Kathleen M, McIntyre, Kim W, Xie, Jenny H, Obermeier, Mary T, Fura, Aberra, Sleczka, Bogdan, Stefanski, Kevin, Fancher, R. M, Padmanabhan, Shweta, RP, Thatipamula, Kundu, Ipsit, Rajareddy, Kallem, Smith, Rodney, Hennan, James K, Xing, Dezhi, Fan, Jingsong, Levesque, Paul C, Ruan, Qian, Pitt, Sidney, Zhang, Rosemary, Pedicord, Donna, Pan, Jie, Yarde, Melissa, Lu, Hao, Lippy, Jonathan, Goldstine, Christine, Skala, Stacey, Rampulla, Richard A, Mathur, Arvind, Gupta, Anuradha, Arunachalam, Pirama Nayagam, Sack, John S, Muckelbauer, Jodi K, Cvijic, Mary Ellen, Salter-Cid, Luisa M, Bhide, Rajeev S, Poss, Michael A, Hynes, John, Carter, Percy H, Macor, John E, Ruepp, Stefan, Schieven, Gary L, Tino, Joseph A

Volltext

Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins von Labow, Mark A., Norton, Christine R., Rumberger, John M., Lombard-Gillooly, Kathleen M., Shuster, David J., Hubbard, Jennifer, Bertko, Robert, Knaack, Polly A., Terry, Robert W., Harbison, Margaret L., Kontgen, Frank, Stewart, Colin L., McIntyre, Kim W., Will, Peter C., Burns, Daniel K., Wolitzky, Barry A.

Volltext

Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for th... von Liu, Chunjian, Lin, James, Wrobleski, Stephen T, Lin, Shuqun, Hynes, John, Wu, Hong, Dyckman, Alaric J, Li, Tianle, Wityak, John, Gillooly, Kathleen M, Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary F, McIntyre, Kim W, Salter-Cid, Luisa, Shuster, David J, Zhang, Hongjian, Marathe, Punit H, Doweyko, Arthur M, Sack, John S, Kiefer, Susan E, Kish, Kevin F, Newitt, John A, McKinnon, Murray, Dodd, John H, Barrish, Joel C, Schieven, Gary L, Leftheris, Katerina

Volltext

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK von Srivastava, Anurag S, Ko, Soo, Watterson, Scott H, Pattoli, Mark A, Skala, Stacey, Cheng, Lihong, Obermeier, Mary T, Vickery, Rodney, Discenza, Lorell N, D’Arienzo, Celia J, Gillooly, Kathleen M, Taylor, Tracy L, Pulicicchio, Claudine, McIntyre, Kim W, Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Dai, Jun, Wang, Chunlei, Zhang, Yingru, Wang, Bei, Pawluczyk, Joseph, Kempson, James, Zhao, Rulin, Hou, Xiaoping, Rampulla, Richard, Mathur, Arvind, Galella, Michael A, Salter-Cid, Luisa, Barrish, Joel C, Carter, Percy H, Fura, Aberra, Burke, James R, Tino, Joseph A

Volltext

Rational Design and Synthesis of an Orally Active Indolopyridone as a Novel Conformationally Constrained Cannabinoid Ligand Possessing Antiinflammatory Properties von Wrobleski, Stephen T, Chen, Ping, Hynes, John, Lin, Shuqun, Norris, Derek J, Pandit, Chennagiri R, Spergel, Steven, Wu, Hong, Tokarski, John S, Chen, Xiaorong, Gillooly, Kathleen M, Kiener, Peter A, McIntyre, Kim W, Patil-koota, Vina, Shuster, David J, Turk, Lori A, Yang, Guchen, Leftheris, Katerina

Volltext

Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38α Mitogen-Activated Protein Kinase Inhibitors von Hynes, John, Dyckman, Alaric J, Lin, Shuqun, Wrobleski, Stephen T, Wu, Hong, Gillooly, Kathleen M, Kanner, Steven B, Lonial, Herinder, Loo, Derek, McIntyre, Kim W, Pitt, Sidney, Shen, Ding Ren, Shuster, David J, Yang, XiaoXia, Zhang, Rosemary, Behnia, Kamelia, Zhang, Hongjian, Marathe, Punit H, Doweyko, Arthur M, Tokarski, John S, Sack, John S, Pokross, Matthew, Kiefer, Susan E, Newitt, John A, Barrish, Joel C, Dodd, John, Schieven, Gary L, Leftheris, Katerina

Volltext

Quasi-distributed strain sensor incorporating a chirped Moire´ fiber Bragg grating von Gillooly, A M, Zhang, L, Bennion, I

Volltext

Differential effect of E-selectin antibodies on neutrophil rolling and recruitment to inflammatory sites von RAMOS, C. L, KUNKEL, E. J, LEY, K, LAWRENCE, M. B, JUNG, U, VESTWEBER, D, BOSSE, R, MCINTYRE, K. W, GILLOOLY, K. M, NORTON, C. R, WOLITZKY, B. A

Volltext

Implementation of a distributed temperature sensor utilising a chirped Moiré fibre Bragg grating von Gillooly, A.M., Zhang, L., Bennion, I.

Volltext

Collagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs von Lang, M R, Fiaux, G W, Gillooly, M, Stewart, J A, Hulmes, D J, Lamb, D

Volltext

Chirped fibre Bragg grating optical wear sensor von Gillooly, A M, Chisholm, K E, Zhang, L, Bennion, I

Volltext

Discovery of pyrrolo[2,1- f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors von Dyckman, Alaric J., Li, Tianle, Pitt, Sidney, Zhang, Rosemary, Shen, Ding Ren, McIntyre, Kim W., Gillooly, Kathleen M., Shuster, David J., Doweyko, Arthur M., Sack, John S., Kish, Kevin, Kiefer, Susan E., Newitt, John A., Zhang, Hongjian, Marathe, Punit H., McKinnon, Murray, Barrish, Joel C., Dodd, John H., Schieven, Gary L., Leftheris, Katerina

Volltext