NKG2D-based chimeric antigen receptor therapy induced remission in a relapsed/refractory acute myeloid leukemia patient von Sallman, David A, Brayer, Jason, Sagatys, Elizabeth M, Lonez, Caroline, Breman, Eytan, Agaugué, Sophie, Verma, Bikash, Gilham, David E, Lehmann, Frédéric F, Davila, Marco L

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Overcoming Target Driven Fratricide for T Cell Therapy von Breman, Eytan, Demoulin, Benjamin, Agaugué, Sophie, Mauën, Sebastien, Michaux, Alexandre, Springuel, Lorraine, Houssa, Julien, Huberty, Fanny, Jacques-Hespel, Céline, Marchand, Céline, Marijsse, Jérôme, Nguyen, Thuy, Ramelot, Nancy, Violle, Benjamin, Daro, Dorothée, De Waele, Peter, Gilham, David E, Steenwinckel, Valérie

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CAR–T cells and solid tumors: tuning T cells to challenge an inveterate foe von Gilham, David E, Debets, Reno, Pule, Martin, Hawkins, Robert E, Abken, Hinrich

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The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respirator... von Thistlethwaite, Fiona C., Gilham, David E., Guest, Ryan D., Rothwell, Dominic G., Pillai, Manon, Burt, Deborah J., Byatte, Andrea J., Kirillova, Natalia, Valle, Juan W., Sharma, Surinder K., Chester, Kerry A., Westwood, Nigel B., Halford, Sarah E. R., Nabarro, Stephen, Wan, Susan, Austin, Eric, Hawkins, Robert E.

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CAR T cells: driving the road from the laboratory to the clinic von Cheadle, Eleanor J., Gornall, Hannah, Baldan, Vania, Hanson, Vivien, Hawkins, Robert E., Gilham, David E.

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Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma von Baumeister, Susanne H, Murad, Joana, Werner, Lillian, Daley, Heather, Trebeden-Negre, Helene, Gicobi, Joanina K, Schmucker, Adam, Reder, Jake, Sentman, Charles L, Gilham, David E, Lehmann, Frédéric F, Galinsky, Ilene, DiPietro, Heidi, Cummings, Kristen, Munshi, Nikhil C, Stone, Richard M, Neuberg, Donna S, Soiffer, Robert, Dranoff, Glenn, Ritz, Jerome, Nikiforow, Sarah

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Eotaxin-2 and Colorectal Cancer: A Potential Target for Immune Therapy von CHEADLE, Eleanor J, RIYAD, Kallingal, SUBAR, Daren, ROTHWELL, Dominic G, ASHTON, Garry, BATHA, Hayley, SHERLOCK, David J, HAWKINS, Robert E, GILHAM, David E

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Preclinical Assessment of CAR T-Cell Therapy Targeting the Tumor Antigen 5T4 in Ovarian Cancer von Owens, Gemma L, Sheard, Victoria E, Kalaitsidou, Milena, Blount, Daniel, Lad, Yatish, Cheadle, Eleanor J, Edmondson, Richard J, Kooner, Gurdeep, Gilham, David E, Harrop, Richard

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Targeted immunotherapy of cancer with CAR T cells: achievements and challenges von Lipowska-Bhalla, Grazyna, Gilham, David E., Hawkins, Robert E., Rothwell, Dominic G.

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Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies von Springuel, Lorraine, Lonez, Caroline, Alexandre, Bertrand, Van Cutsem, Eric, Machiels, Jean-Pascal H., Van Den Eynde, Marc, Prenen, Hans, Hendlisz, Alain, Shaza, Leila, Carrasco, Javier, Canon, Jean-Luc, Opyrchal, Mateusz, Odunsi, Kunle, Rottey, Sylvie, Gilham, David E., Flament, Anne, Lehmann, Frédéric F.

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Ex vivo expanded tumour-infiltrating lymphocytes from ovarian cancer patients release anti-tumour cytokines in response to autologous primary ovarian cancer cells von Owens, Gemma L., Price, Marcus J., Cheadle, Eleanor J., Hawkins, Robert E., Gilham, David E., Edmondson, Richard J.

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The integrated stress response promotes B7H6 expression von Obiedat, Akram, Charpak-Amikam, Yoav, Tai-Schmiedel, Julie, Seidel, Einat, Mahameed, Mohamed, Avril, Tony, Stern-Ginossar, Noam, Springuel, Lorraine, Bolsée, Jennifer, Gilham, David E., Dipta, Priya, Shmuel, Miriam, Chevet, Eric, Mandelboim, Ofer, Tirosh, Boaz

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'Atypical' CAR T cells: NKG2D and Erb-B as examples of natural receptor/ligands to target recalcitrant solid tumors von Gilham, David E, Maher, John

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Exploiting natural killer group 2D receptors for CAR T-cell therapy von Demoulin, Benjamin, Cook, W. James, Murad, Joana, Graber, David J, Sentman, Marie-Louise, Lonez, Caroline, Gilham, David E, Sentman, Charles L, Agaugue, Sophie

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Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival von Griffiths, Richard W, Elkord, Eyad, Gilham, David E, Ramani, Vijay, Clarke, Noel, Stern, Peter L, Hawkins, Robert E

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O 6-Methylguanine-DNA methyltransferase inactivation and chemotherapy von Verbeek, Barbara, Southgate, Thomas D., Gilham, David E., Margison, Geoffrey P.

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A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells von Kueberuwa, Gray, Zheng, Weiming, Kalaitsidou, Milena, Gilham, David E, Hawkins, Robert E

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CYAD-01, an autologous NKG2D-based CAR T-cell therapy, in relapsed or refractory acute myeloid leukaemia and myelodysplastic syndromes or multiple myeloma (THINK): haematological c... von Sallman, David A, Kerre, Tessa, Havelange, Violaine, Poiré, Xavier, Lewalle, Philippe, Wang, Eunice S, Brayer, Jason B, Davila, Marco L, Moors, Ine, Machiels, Jean-Pascal, Awada, Ahmad, Alcantar-Orozco, Erik M, Borissova, Rossitza, Braun, Nathalie, Dheur, Marie-Sophie, Gilham, David E, Lonez, Caroline, Lehmann, Frédéric F, Flament, Anne

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Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model von Cheadle, Eleanor J, Sheard, Victoria, Rothwell, Dominic G, Bridgeman, John S, Ashton, Garry, Hanson, Vivien, Mansoor, A Wasat, Hawkins, Robert E, Gilham, David E

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Study protocol for THINK: a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metast... von Lonez, Caroline, Verma, Bikash, Hendlisz, Alain, Aftimos, Philippe, Awada, Ahmad, Van Den Neste, Eric, Catala, Gaetan, Machiels, Jean-Pascal H, Piette, Fanny, Brayer, Jason B, Sallman, David A, Kerre, Tessa, Odunsi, Kunle, Davila, Marco L, Gilham, David E, Lehmann, Frédéric F

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