PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome von Kroeze, Wesley K, Sassano, Maria F, Huang, Xi-Ping, Lansu, Katherine, McCorvy, John D, Giguère, Patrick M, Sciaky, Noah, Roth, Bryan L

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A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior von Vardy, Eyal, Robinson, J. Elliott, Li, Chia, Olsen, Reid H.J., DiBerto, Jeffrey F., Giguere, Patrick M., Sassano, Flori M., Huang, Xi-Ping, Zhu, Hu, Urban, Daniel J., White, Kate L., Rittiner, Joseph E., Crowley, Nicole A., Pleil, Kristen E., Mazzone, Christopher M., Mosier, Philip D., Song, Juan, Kash, Thomas L., Malanga, C.J., Krashes, Michael J., Roth, Bryan L.

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Molecular control of δ-opioid receptor signalling von Fenalti, Gustavo, Giguere, Patrick M., Katritch, Vsevolod, Huang, Xi-Ping, Thompson, Aaron A., Cherezov, Vadim, Roth, Bryan L., Stevens, Raymond C.

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Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets von Kimple, Adam J, Bosch, Dustin E, Giguère, Patrick M, Siderovski, David P

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Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based high-throughput platform von Zeghal, Manel, Laroche, Geneviève, Freitas, Julia Douglas, Wang, Rebecca, Giguère, Patrick M.

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Development of a V5-tag–directed nanobody and its implementation as an intracellular biosensor of GPCR signaling von Zeghal, Manel, Matte, Kevin, Venes, Angelica, Patel, Shivani, Laroche, Geneviève, Sarvan, Sabina, Joshi, Monika, Rain, Jean-Christophe, Couture, Jean-François, Giguère, Patrick M.

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DREADDs: novel tools for drug discovery and development von Lee, Hyeong-Min, Giguere, Patrick M., Roth, Bryan L.

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Distinct functional roles for the M4 α-helix from each homologous subunit in the heteropentameric ligand-gated ion channel nAChR von Thompson, Mackenzie J., Domville, Jaimee A., Edrington, Claire H., Venes, Angelica, Giguère, Patrick M., Baenziger, John E.

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Functional Characterization of Sodium Channel Inhibitors at the Delta-Opioid Receptor von Mohamud, Abdulhamid O., Zeghal, Manel, Patel, Shivani, Laroche, Geneviève, Blgacim, Nuria, Giguère, Patrick M.

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Parallel Interrogation of beta-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay von Zeghal, Manel, Laroche, Genevieve, Giguere, Patrick M.

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Tuning up the right signal: chemical and genetic approaches to study GPCR functions von Giguere, Patrick M, Kroeze, Wesley K, Roth, Bryan L

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A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation von Zha, Zhengyu, Han, Xiaoran, Smith, Matthew D., Liu, Yang, Giguère, Patrick M., Kopanja, Dragana, Raychaudhuri, Pradip, Siderovski, David P., Guan, Kun-Liang, Lei, Qun-Ying, Xiong, Yue

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Propagation of the Allosteric Modulation Induced by Sodium in the [delta]-Opioid Receptor von Sun, Xianqiang, Laroche, Genevieve, Wang, Xu, Agren, Hans, Bowman, Gregory R, Giguere, Patrick M, Tu, Yaoquan

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Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease von Karunakaran, Gapisha, Yang, Yidai, Tremblay, Véronique, Ning, Zhibin, Martin, Jade, Belaouad, Amine, Figeys, Daniel, Brunzelle, Joseph S., Giguere, Patrick M., Stintzi, Alain, Couture, Jean‐François

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Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists von Cheng, Jianjun, McCorvy, John D, Giguere, Patrick M, Zhu, Hu, Kenakin, Terry, Roth, Bryan L, Kozikowski, Alan P

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Structure-based discovery of opioid analgesics with reduced side effects von Manglik, Aashish, Lin, Henry, Aryal, Dipendra K., McCorvy, John D., Dengler, Daniela, Corder, Gregory, Levit, Anat, Kling, Ralf C., Bernat, Viachaslau, Hübner, Harald, Huang, Xi-Ping, Sassano, Maria F., Giguère, Patrick M., Löber, Stefan, Da Duan, Scherrer, Grégory, Kobilka, Brian K., Gmeiner, Peter, Roth, Bryan L., Shoichet, Brian K.

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The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy von Lei, Yu, Wen, Haitao, Yu, Yanbao, Taxman, Debra J., Zhang, Lu, Widman, Douglas G., Swanson, Karen V., Wen, Kwun-Wah, Damania, Blossom, Moore, Chris B., Giguère, Patrick M., Siderovski, David P., Hiscott, John, Razani, Babak, Semenkovich, Clay F., Chen, Xian, Ting, Jenny P.-Y.

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Design and synthesis of (2-(5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a selective serotonin 2C agonist von Cheng, Jianjun, Giguere, Patrick M., Lv, Wei, Roth, Bryan L., Kozikowski, Alan P.

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Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models von Cheng, Jianjun, Giguere, Patrick M, Schmerberg, Claire M, Pogorelov, Vladimir M, Rodriguiz, Ramona M, Huang, Xi-Ping, Zhu, Hu, McCorvy, John D, Wetsel, William C, Roth, Bryan L, Kozikowski, Alan P

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Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen von Taha, Zaid, Arulanandam, Rozanne, Maznyi, Glib, Godbout, Elena, Carter-Timofte, Madalina E., Kurmasheva, Naziia, Reinert, Line S., Chen, Andrew, Crupi, Mathieu J.F., Boulton, Stephen, Laroche, Geneviève, Phan, Alexandra, Rezaei, Reza, Alluqmani, Nouf, Jirovec, Anna, Acal, Alexandra, Fekete, Emily E.F., Singaravelu, Ragunath, Petryk, Julia, Idorn, Manja, Potts, Kyle G., Todesco, Hayley, John, Cini, Mahoney, Douglas J., Ilkow, Carolina S., Giguère, Patrick, Alain, Tommy, Côté, Marceline, Paludan, Søren R., Olagnier, David, Bell, John C., Azad, Taha, Diallo, Jean-Simon

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